World’s First Virtual Reality Surgery

Doctors at the Avicenne de Bobigny hospital (Ile-de-France) have successfully completed the world’s first ever augmented-reality surgical operation using 3D models and a virtual reality (VR) headset.

Doctor Thomas Grégory, head of orthopedic and traumatic surgery at the university teaching hospital, was able to “see through the skin of his patient” before the shoulder operation, through the use of 3D imaging technology and models created from the 80-year-old patient ahead of time.

During the key part of the operation, which lasted for 45 minutes, the doctors in France were joined by video link by four surgeons from South Korea, the USA, and the UK, who provided help via online call programme Skype.

Dr Grégory also performed the procedure while wearing a “mixed reality headset from Microsoft’s Hololens, which he could control with his movements and his voice, allowing him to see 3D images projected onto the anatomy of the patient during the operation, as well as enabling him to consult advisory videos and supporting medical documents. He had begun to practice on the device two months previously, he said.

It was a global first for this kind of operation, and purported to help the surgeons understand – to a much higher degree than normal – what they would find during the surgery, allowing them to prepare more and improve the quality of care overall. The headset also allowed the surgeons to operate with a previously unprecedentedlevel of precision”, that was less invasive, more effective, and less prone to infection after the fact.

The holy grail for a doctor is to [find a way] to see what we cannot see with our own eyes; the patient’s skeleton in every detail. That is what [this allows] us to do,” explained Grégory.

Source: https://www.connexionfrance.com/

Startups Produce Beef, Chicken, And Duck From Animal Cells

Alternative or “clean” meat startup Memphis Meats announced Wednesday morning that it has completed a $17 million Series A fundraising round. The company has now raised $22 million to date.

The round was led by venture capital firm DFJ. Cargill, Bill Gates, and Richard Branson also invested, as did European venture capital fund Atomico, New Crop Capital, SOSV, Fifty Years, KBW Ventures, Inevitable Ventures, Suzy Welch, Kyle Vogt, and Kimbal Musk. Several research institutions also joined the round.

Memphis Meats has yet to commercialize a product but has produced beef, chicken, and duck from animal cells. The company grows meat in tanks by feeding oxygen, sugar, and other nutrients to living animal cells.

 

In addition to the bold-faced names who have lent their support and dollars to the company, the round was significant for its inclusion of Cargill. While other parts of the food industry, such as dairy, have resisted the mainstreaming of animal product alternatives like almond milk, the move by Cargill shows the meat sector may be taking a different approach. Tyson, for example, has also invested in the sector, backing plant-based meat company Beyond Meat.

Source: http://fortune.com/

Light-Powered Wires To Modulate Brain’s Electrical Signals

The human brain largely remains a black box: How the network of fast-moving electrical signals turns into thought, movement and disease remains poorly understood. But it is electrical, so it can be hacked—the question is finding a precise, easy way to manipulate electrical signaling between neurons.

A new University of Chicago study shows how tiny, light-powered wires could be fashioned out of silicon to provide these electrical signals. Published Feb. 19 in Nature Nanotechnology, the study offers a new avenue to shed light on—and perhaps someday treat—brain disorders.

Ten years ago, the science world was alive with speculation about a recently discovered technique called optogenetics, which would manipulate neural activity with light. The problem is that it has to be done with genetics: inserting a gene into a target cell that would make it respond to light. Other ways of modulating neurons have since been suggested, but a perfect alternative remains elusive.

A team led by Asst. Prof. Bozhi Tian built minuscule wires previously designed for solar cells. These nanowires are so small that hundreds of them could sit side by side on the edge of a sheet of paper—putting them on the same scale as the parts of cells they’re trying to communicate with.

These nanowires combine two types of silicon to create a small electrical current when struck by light. Gold, diffused by a special process onto the surface of the wire, acts as a catalyst to promote electrochemical reactions.

The rod at top right is positioned to modify electrical signaling between the neurons. The entire image is smaller than the diameter of a single human hair.

When the wire is in place and illuminated, the voltage difference between the inside and outside of the cell is slightly reduced. This lowers the barrier for the neuron to fire an electrical signal to its neighboring cells,” Tian said.

Source: https://news.uchicago.edu/

How To Fight Against Resistant SuperBugs

British biopharma firm Helperby Therapeutics, a spin-out drug discovery company from St George’s University of London, has developed a novel answer to the clear and present danger of antimicrobial resistanceAntibiotic Resistance Breakers (ARBs). Doctors increasingly rely on last resort antibiotics such as carbapenems and colistin, but as harmful bacteria continue to mutate, this final line of resistance will eventually failHelperby’s solution to this critical problem, and ground-breaking innovation, is Antibiotic Resistance Breakers – novel technology that rejuvenates existing antibiotics into long-term effective combination therapies.

The World Health Organization (WHO) has identified the immediate threat from three critical priority pathogens for which there is currently limited antibiotic protection:

  • CRE (Carbapenem-resistant Enterobacteriaceae)
  • Pseudomonas aeruginosa(Carbapenem-resistant)
  • Acinetobacter (Carbapenem-resistant)

The most dangerous bacteria are CRE, causing severe and often fatal infections such as septicemia and pneumonia.CRE has spread from Asia into Europe and the USA, is epidemic and doubles every two years. 

Helperby’s Antibiotic Resistance Breakers rejuvenate existing antibiotics, enabling them to puncture the tough cell wall of CRE and other evolving superbugs to allow existing last-resort antibiotics to effectively do their work. The ARB rejuvenation process can be performed repeatedly on different combinations of existing antibiotics to outsmart resistance.

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New classes of antibiotics are difficult to develop, and none have been marketed for over 30 years,” said Prof Anthony Coates, chief scientific officer of Helperby Therapeutics. “It is therefore imperative we keep existing antibiotics working. We are one of only six companies in the world that have new antibiotics in clinical development which are potentially effective against all three of WHO’s critical priority pathogens,” he added.

ARBs are novel, effective and transferable, potentially producing many variants of new antibiotic combination. One ARB can be applied to multiple different classes of antibiotics, reducing the size, time and resource in Phase III clinical trials normally required for new chemical entities.

Source: https://www.thepharmaletter.com/

Simple Blood Test To Detect Eight Types Of Cancer

Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer.

The test, called CancerSEEK, is a unique noninvasive, multianalyte test that simultaneously evaluates levels of eight cancer proteins and the presence of cancer gene mutations from circulating DNA in the blood. The test is aimed at screening for eight common cancer types that account for more than 60 percent of cancer deaths in the U.S. Five of the cancers covered by the test currently have no screening test.

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The use of a combination of selected biomarkers for early detection has the potential to change the way we screen for cancer, and it is based on the same rationale for using combinations of drugs to treat cancers,” says Nickolas Papadopoulos, Ph.D., senior author and professor of oncology and pathology.

Circulating tumor DNA mutations can be highly specific markers for cancer. To capitalize on this inherent specificity, we sought to develop a small yet robust panel that could detect at least one mutation in the vast majority of cancers,” adds Joshua Cohen, an M.D.-Ph.D. student at the Johns Hopkins University School of Medicine and the paper’s first author. “In fact, keeping the mutation panel small is essential to minimize false-positive results and keep such screening tests affordable.”

The findings were published online by Science.

Source: https://www.hopkinsmedicine.org/

How To Detect Alzheimer’s 30 years In Advance

Scientists from Japan and Australia have teamed up to develop and validate a blood test for Alzheimer’s disease, with the potential to massively ramp up the pace of Alzheimer’s disease drug trials. The blood test measures a specific peptide in the blood to inform scientists, with 90 per cent accuracy, if a patient has the very earliest stages of Alzheimer’s diseaseBlood samples from patients in a large study from the Japanese National Center for Geriatrics and Gerontology (NCGG) were initially analysed to identify the relevant peptides. Those indicating brain beta-amyloid burden were then tested against patient samples from the Australian Imaging, Biomarker and Lifestyle Study of Aging (AIBL), to validate the results.

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Our study demonstrates the high accuracy, reliability and reproducibility of this blood test, as it was successfully validated in two independent large datasets from Japan and Australia.” says Professor Katsuhiko Yanagisawa, Director-general of Research Institute at NCGG.

Dr Koichi Tanaka at Shimadzu Corporation was instrumental in developing the initial blood testing procedure. Professor Tanaka won the Nobel prize in Chemistry in 2002 for the technique. “From a tiny blood sample, our method can measure several amyloid-related proteins, even though their concentration is extremely low. We found that the ratio of these proteins was an accurate surrogate for brain amyloid burden.”

One of the essential hallmarks of Alzheimer’s disease is buildup of abnormal peptide in the brain, called beta-amyloid. The process starts silently about 30 years before outward signs of dementia, like memory loss or cognitive decline, have begun.

Current tests for beta-amyloid include brain scans with costly radioactive tracers, or analysing spinal fluid taken via a lumbar puncture. These are expensive and invasive, and generally only available in a research setting. A diagnosis is usually made without these tools, by assessing a patient’s range of symptoms.

Laureate Professor Colin Masters of the Florey Institute of Neuroscience and Mental Health, and The University of Melbourne, has been at the forefront of Alzheimer’s research since the 1980s. Professor Masters, who co-led the research published in the latest issue of Nature, comments: “This new test has the potential to eventually disrupt the expensive and invasive scanning and spinal fluid technologies. In the first instance, however, it will be an invaluable tool in increasing the speed of screening potential patients for new drug trials.

Source: https://www.florey.edu.au/

TriboElectricity, The Green Energy Source

Researchers from Clemson’s Nanomaterials Institute (CNI) are one step closer to wirelessly powering the world using triboelectricity, a green energy source. In March 2017, a group of physicists at CNI invented the ultra-simple triboelectric nanogenerator or U-TENG, a small device made of plastic and tape that generates electricity from motion and vibrations. When the two materials are brought together — through such actions as clapping the hands or tapping feet — they generate voltage that is detected by a wired, external circuit. Electrical energy, by way of the circuit, is then stored in a capacitor or a battery until it’s needed.

Nine months later, in a paper published in the journal Advanced Energy Materials, the researchers reported that they had created a wireless TENG, called the W-TENG, which greatly expands the applications of the technology. The W-TENG was engineered under the same premise as the U-TENG using materials that are so opposite in their affinity for electrons that they generate a voltage when brought in contact with each other.

In the W-TENG, plastic was swapped for a multipart fiber made of graphene — a single layer of graphite, or pencil lead — and a biodegradable polymer known as polylactic acid (PLA). PLA on its own is great for separating positive and negative charges, but not so great at conducting electricity, which is why the researchers paired it with graphene. Kapton tape, the electron-grabbing material of the U-TENG, was replaced with Teflon, a compound known for coating nonstick cooking pans.

After assembling the graphene-PLA fiber, the researchers pulled it into a 3-D printer and the W-TENG was born. The end result is a device that generates a maximum of 3,000 volts — enough to power 25 standard electrical outlets or, on a grander scale, smart-tinted windows or a liquid crystal display (LCD) monitor. Because the voltage is so high, the W-TENG generates an electric field around itself that can be sensed wirelessly. Its electrical energy, too, can be stored wirelessly in capacitors and batteries.

It cannot only give you energy, but you can use the electric field also as an actuated remote. For example, you can tap the W-TENG and use its electric field as a ‘button’ to open your garage door, or you could activate a security system — all without a battery, passively and wirelessly,” said Sai Sunil Mallineni, the first author of the study and a Ph.D. student in physics and astronomy.

Source: http://newsstand.clemson.edu
/

Hard Material With Self-Healing Capability

Imagine a cellphone that can heal from cuts and scratches just like the human body can. For Chinese researcher Ming Yang and his team at the Harbin Institute of Technology, it’s not really a question of imagining anymore: They have developed a new kind of smart coating that manages to be both soft and hard, not unlike our own skin.

We designed a self-healing coating with a hardness that even approaches tooth enamel by mimicking the structure of epidermis,” Yang says. “This is the most desirable property combination in the current self-healing materials and coatings.”

As described in a paper published Wednesday in ACS Nano, this new material is far from the first smart coating, with previous research looking at both soft and hard coating options. Yang says there’s serious global need for better self-healing materials.

Nowadays people always talk about environment and energy,” he adds. “A self-healing material can help save a lot of money and energy using a smart, environmental friendly way. But the current self-healing materials and coatings are typically soft and wear out quickly. This can bring potential problems about the management of plastic waste.

This new material could solve those waste problems, as it comes closer than any predecessor to combining the flexibility of a soft coating and the resilience of a hard coating, without the short lifespan of the former or the brittleness of the latter. This could be the best of both worlds.

The trick is to use artificial materials in nature’s way,” explains Yang. “The multilayer structure is the key. By placing a hard layer containing graphene oxide on top of a soft layer, we create a smart hybridization you can get the most out of.”

The graphene oxide material used in the coating’s top layer is harder than skin cells, offering a toughness closer to that of teeth enamel. The amazing thing, according to Yang, is that the coating’s hard and soft layers are able to work together to create healing properties that neither could accomplish on its own.

Source: https://pubs.acs.org/
A
ND
https://www.inverse.com/

Hydrogen Economy Closer

Washington State University (WSU) researchers have found a way to more efficiently generate hydrogen from water — an important key to making clean energy more viable. Using inexpensive nickel and iron, the researchers developed a very simple, five-minute method to create large amounts of a high-quality catalyst required for the chemical reaction to split water.

Energy conversion and storage is a key to the clean energy economy. Because solar and wind sources produce power only intermittently, there is a critical need for ways to store and save the electricity they create. One of the most promising ideas for storing renewable energy is to use the excess electricity generated from renewables to split water into oxygen and hydrogen. Hydrogen has myriad uses in industry and could be used to power hydrogen fuel-cell carsIndustries have not widely used the water splitting process, however, because of the prohibitive cost of the precious metal catalysts that are required – usually platinum or ruthenium. Many of the methods to split water also require too much energy, or the required catalyst materials break down too quickly.

In their work, the researchers, led by professor Yuehe Lin in the School of Mechanical and Materials Engineering, used two abundantly available and cheap metals to create a porous nanofoam that worked better than most catalysts that currently are used, including those made from the precious metals. The catalyst they created looks like a tiny sponge. With its unique atomic structure and many exposed surfaces throughout the material, the nanofoam can catalyze the important reaction with less energy than other catalysts. The catalyst showed very little loss in activity in a 12-hour stability test.

We took a very simple approach that could be used easily in large-scale production,” said Shaofang Fu, a WSU Ph.D. student who synthesized the catalyst and did most of the activity testing. “The advanced materials characterization facility at the national laboratories provided the deep understanding of the composition and structures of the catalysts,” comments Junhua Song, another WSU Ph.D. student who worked on the catalyst characterization.

The findings are described in the journal Nano Energy.

Source: https://news.wsu.edu/

Monkeys Have Been Cloned, Humans Could Be Next

Chinese scientists have cloned monkeys using the same technique that produced Dolly the Sheep two decades ago, breaking a technical barrier that could open the door to copying humans.  Zhong Zhong and Hua Hua, two identical long-tailed macaques, were born eight and six weeks ago, making them the first primates — the order of mammals that includes monkeys, apes and humans — to be cloned from a non-embryonic cell.

It was achieved through a process called somatic cell nuclear transfer (SCNT), which involves transferring the nucleus of a cell, which includes its DNA, into an egg which has had its nucleus removed. Researchers at the Chinese Academy of Sciences Institute of Neuroscience in Shanghai said their work should be a boon to medical research by making it possible to study diseases in populations of genetically uniform monkeys. But it also brings the feasibility of cloning to the doorstep of our own species.

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Humans are primates. So [for] the cloning of primate species, including humans, the technical barrier is now broken,” said Muming Poo, who helped supervise the program at the institute.

“The reason … we broke this barrier is to produce animal models that are useful for medicine, for human health.

Genetically identical animals are useful in research because confounding factors caused by genetic variability in non-cloned animals can complicate experiments. They could be used to test new drugs for a range of diseases before clinical use. The two newborns are now being bottle-fed and are growing normally.

Source: http://www.abc.net.au/

3D Printed Ears

A group of researchers in China has constructed ears for children suffering from microtia, a congenital condition where the external ear (pinna) is underdeveloped, with the help of 3D scanning and 3D printing.

The scientists, from Shanghai Jiao Tong University, the National Tissue Engineering Research Center of China, the Chinese Academy of Medical ScienceWei Fang Medical College and Dalian University, engineered a patient-specific ear-shaped cartilage in vitro using a 3D printed biodegradable scaffold and Microtia Chondrocyte (MCs) cartilage cells.

Microtia can have a negative impact on the hearing and wellbeing of children affected by it. Established procedures to treat microtia include rib cartilage reconstruction, plastic implants or prostheses.

Projects like Australia’s FutureHear are 3D printing customized ear molds, while Dr. Ken Stewart of the Royal Hospital for Sick Children in Edinburgh has used 3D scanning and 3D printed models to prepare cartilage reconstructions accurately in the shape of an ear.

This approach, however, combined 3D printing with in vitro tissue engineering on children suffering from microtia only in one ear.

Source: http://www.ebiomedicine.com/
AND
https://3dprintingindustry.com/

Flexible, Low-Cost, Water-Repellent Gaphene Circuits

New graphene printing technology can produce electronic circuits that are low-cost, flexible, highly conductive and water repellent. The nanotechnology “would lend enormous value to self-cleaning wearable/washable electronics that are resistant to stains, or ice and biofilm formation,” according to a recent paper describing the discovery.

“We’re taking low-cost, inkjet-printed graphene and tuning it with a laser to make functional materials,” said Jonathan Claussen, an Iowa State University assistant professor of mechanical engineering, an associate of the U.S. Department of Energy’s and the corresponding author of the paper recently featured on the cover of the journal Nanoscale. The paper describes how Claussen and the nanoengineers in his research group use to create electric circuits on flexible materials. In this case, the ink is flakes of graphene – the wonder material can be a great conductor of electricity and heat, plus it’s strong, stable and biocompatible.

And now they’ve found another application of their laser processing technology: taking graphene-printed circuits that can hold water droplets (they’re hydrophilic) and turning them into circuits that repel water (they’re superhydrophobic).

We’re micro-patterning the surface of the inkjet-printed graphene,” Claussen said. “The laser aligns the graphene flakes vertically – like little pyramids stacking up. And that’s what induces the hydrophobicity.” Claussen said the energy density of the laser processing can be adjusted to tune the degree of hydrophobicity and conductivity of the printed graphene circuits. And that opens up all kinds of possibilities for new electronics and sensors, according to the paper. “One of the things we’d be interested in developing is anti-biofouling materials,” said Loreen Stromberg, a paper co-author and an Iowa State postdoctoral research associate in mechanical engineering and for the Virtual Reality Applications Center. “This could eliminate the buildup of biological materials on the surface that would inhibit the optimal performance of devices such as chemical or biological sensors.”

The technology could also have applications in flexible electronics, washable sensors in textiles, microfluidic technologies, drag reduction, de-icing, electrochemical sensors and technology that uses graphene structures and electrical simulation to produce stem cells for nerve regeneration. The researchers wrote that further studies should be done to better understand how the nano– and microsurfaces of the printed graphene creates the water-repelling capabilities. .

The Iowa State University Research Foundation is working to patent the technology and has optioned it to an Ames-based startup, NanoSpy Inc., for possible commercialization. NanoSpy, located at the Iowa State University Research Park, is developing sensors to detect salmonella and other pathogens in food processing plants. Claussen and Stromberg are part of the company.

Source: https://www.news.iastate.edu/

Universal Vaccine Against Influenza A Viruses

Researchers have developed a universal vaccine to combat influenza A viruses that produces long-lasting immunity in mice and protects them against the limitations of seasonal flu vaccines, according to a study led by Georgia State UniversityInfluenza, a contagious respiratory illness that infects the nose, throat and lungs, is among the leading causes of death in the United States, according to the Centers for Disease Control and Prevention (CDC). The CDC estimates influenza has resulted in between 12,000 and 56,000 deaths annually in the U.S. since 2010. Seasonal flu vaccines must be updated each year to match the influenza viruses that are predicted to be most common during the upcoming flu season, but protection doesn’t always meet expectations or new viruses emerge and manufacturers incorrectly guess which viruses will end up spreading. In 2009, the H1N1 pandemic caused 200,000 deaths during the first 12 months, and low vaccine effectiveness was also observed during the 2014-15 and 2016-17 flu seasons. A universal flu vaccine that offers broad protection against various viruses is urgently needed and would eliminate the limitations of seasonal flu vaccines.

Seasonal flu vaccines provide protective immunity against influenza viruses by targeting the exterior head of the virus’s surface protein, which is hem
agglutinin
(HA). The influenza virus trains the body to produce antibodies against inactivated virus particles containing the head of this protein, ideally preventing the head from attaching to receptors and stopping infection. However, the head is highly variable and is different for each virus, creating a need for better vaccines. This study uses a new approach and instead targets the inside portion of the HA protein known as the stalk, which is more conservative and offers the opportunity for universal protection.

In this study, the researchers found vaccinating mice with double-layered protein nanoparticles that target the stalk of this protein produces long-lasting immunity and fully protects them against various influenza A viruses. The findings are published in the journal Nature Communications.

Source: http://news.gsu.edu/

Artificial Synapse For “Brain-on-a-Chip”

When it comes to processing power, the human brain just can’t be beat. Packed within the squishy, football-sized organ are somewhere around 100 billion neurons. At any given moment, a single neuron can relay instructions to thousands of other neurons via synapses — the spaces between neurons, across which neurotransmitters are exchanged. There are more than 100 trillion synapses that mediate neuron signaling in the brain, strengthening some connections while pruning others, in a process that enables the brain to recognize patterns, remember facts, and carry out other learning tasks, at lightning speeds.

Researchers in the emerging field of “neuromorphic computing” have attempted to design computer chips that work like the human brain. Instead of carrying out computations based on binary, on/off signaling, like digital chips do today, the elements of a “brain on a chip” would work in an analog fashion, exchanging a gradient of signals, or “weights,” much like neurons that activate in various ways depending on the type and number of ions that flow across a synapse.

In this way, small neuromorphic chips could, like the brain, efficiently process millions of streams of parallel computations that are currently only possible with large banks of supercomputers. But one significant hangup on the way to such portable artificial intelligence has been the neural synapse, which has been particularly tricky to reproduce in hardware.

Now engineers at MIT have designed an artificial synapse in such a way that they can precisely control the strength of an electric current flowing across it, similar to the way ions flow between neurons. The team has built a small chip with artificial synapses, made from silicon germanium. In simulations, the researchers found that the chip and its synapses could be used to recognize samples of handwriting, with 95 percent accuracy.

The design, published today in the journal Nature Materials, is a major step toward building portable, low-power neuromorphic chips for use in pattern recognition and other learning tasks.

Source: http://news.mit.edu/

Adding Graphene To Silicon Electrodes Double Lithium Batteries Life

New research led by WMG (academic department), at the University of Warwick (UK) has found an effective approach to replacing graphite in the anodes of lithium-ion batteries using silicon, by reinforcing the anode’s structure with graphene girders. This could more than double the life of rechargeable lithium-ion based batteries by greatly extending the operating lifetime of the electrode, and also increase the capacity delivered by those batteries.

Graphite has been the default choice of active material for anodes in lithium—ion batteries since their original launch by Sony but researchers and manufacturers have long sought a way to replace graphite with silicon, as it is an abundantly available element with ten times the gravimetric energy density of graphite. Unfortunately, silicon has several other performance issues that continue to limit its commercial exploitation.

Due to its volume expansion upon lithiation silicon particles can electrochemically agglomerate in ways that impede further charge-discharge efficiency over time. Silicon is also not intrinsically elastic enough to cope with the strain of lithiation when it is repeatedly charged, leading to cracking, pulverisation and rapid physical degradation of the anode’s composite microstructure. This contributes significantly to capacity fade, along with degradation events that occur on the counter electrode – the cathode. To use the mobile phones as an example, this is why we have to charge our phones for a longer and longer time, and it is also why they don’t hold their charge for as long as when they are new.

However new research, led by Dr Melanie Loveridge in WMG at the University of Warwick, has discovered, and tested, a new anode mixture of silicon and a form of chemically modified graphene which could resolve these issues and create viable silicon anode lithium-ion batteries. Such an approach could be practically manufactured on an industrial scale and without the need to resort to nano sizing of silicon and its associated problems.

The new research has been published in Nature Scientific Reports.

Source: https://warwick.ac.uk/

AI Improves Heart Disease Diagnosis

Researchers from the University of Oxford are using artificial intelligence (AI) to improve diagnostic accuracy for heart disease. The team hope to roll out the system across the NHS later this year, helping to improve patient outcomes and saving millions is misdiagnoses. The research, led by Prof Paul Leeson and RDM DPhil student Ross Upton (Cardiovascular Clinical Research Facility), took place in the Oxford University Hospitals Foundation Trust and is the basis of spin-out company Ultromics.

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Thousands of people every year have an echocardiogram – a type of heart scan – after visiting hospital suffering with chest pain. Clinicians currently assess these scans by eye, taking into account many features that could indicate whether someone has heart disease and if they are likely to go on to have a heart attack. But even the most well trained cardiologist can misdiagnose patients. Currently, 1 in 5 scans are misdiagnosed each year – the equivalent to 12,000 patients. This means that people are either not being treated to prevent a heart attack, or they are undergoing unnecessary operations to stave off a heart attack they won’t have.

The new system uses machine learning – a form of artificial intelligence – to tap into the rich information provided in an echocardiogram. Using the new system, AI can detect 80,000 subtle changes inviable to the naked eye, improving the accuracy of diagnosis to 90%. The machine learning system was trained using scans from previous patients, alongside data about whether they went on to have a heart attack. The team hope that the improved diagnostic accuracy will not only improve patient care and outcomes, but save the NHS £300million a year in avoidable operations and treatment.  So far the system has been trialled in six cardiology units in the UK. Further implementation of the technology is now being led by Ultromics – a spin-out company co-founded by Ross Upton and Paul Leeson (Cardiovascular Clinical Research Facility). The software will be made available for free throughout the NHS later this year.

Source: https://www.rdm.ox.ac.uk/

Making Fuel Cells for a Fraction of the Cost

It is the third announcement in less than one week for a major improvment in the making of fuel cells.

In the competition between Lithium-Ion batteries (e.g. Tesla cars), and hydrogen fuel cells (see picture of Nexo from Hyundai) that power electric cars, it is difficult to predict which one will be the winner at the end.

Fuel cells have the potential to be a clean and efficient way to run cars, computers, and power stations, but the cost of producing them is limiting their use. That’s because a key component of the most common fuel cells is a catalyst made from the precious metal platinum.

In a paper published in Small, researchers at the University of California, Riverside (UCR), describe the development of an inexpensive, efficient catalyst material for a type of fuel cell called a polymer electrolyte membrane fuel cell (PEMFC), which turns the chemical energy of hydrogen into electricity and is among the most promising fuel cell types to power cars and electronics.

The catalyst developed at UCR is made of porous carbon nanofibers embedded with a compound made from a relatively abundant metal such as cobalt, which is more than 100 times less expensive than platinum. The research was led by David Kisailus, the Winston Chung Endowed Professor in Energy Innovation in UCR’s Marlan and Rosemary Bourns College of Engineering.

Fuel cells, which are already being used by some carmakers, offer advantages over conventional combustion technologies, including higher efficiency, quieter operation and lower emissions. Hydrogen fuel cells emit only water.

Like batteries, fuel cells are electrochemical devices that comprise a positive and negative electrode sandwiching an electrolyte. When a hydrogen fuel is injected onto the anode, a catalyst separates the hydrogen molecules into positively charged particles called protons and negatively charged particles called electrons. The electrons are directed through an external circuit, where they do useful work, such as powering an electric motor, before rejoining the positively charged hydrogen ions and oxygen to form water.

A critical barrier to fuel cell adoption is the cost of platinum, making the development of alternative catalyst materials a key driver for their mass implementation.

Using a technique called electrospinning, the UCR researchers made paper-thin sheets of carbon nanofibers that contained metal ions — either cobalt, iron or nickel. Kisailus and his team, collaborating with scientists at Stanford University, determined that the new materials performed as good as the industry standard platinum-carbon systems, but at a fraction of the cost. “The key to the high performance of the materials we created is the combination of the chemistry and fiber processing conditions,” Kisailus said

Source: https://ucrtoday.ucr.edu/

Solar-driven Hydrogen Economy

Hydrogen as a fuel source, rather than hydrocarbons like oil and coal, offers many benefits. Burning hydrogen produces harmless water with the potential to eliminate carbon dioxide emissions and their environmental burden. In pursuit of technologies that could lead to a breakthrough in achieving a hydrogen economy, a key issue is making hydrogen cheaply. Using catalysts to split water is the ideal way to generate hydrogen, but doing so usually requires an energy input from other chemicals, electricity, or a portion of sunlight which has high enough energy.

Now researchers at Osaka University have developed a new catalytic system for efficiently splitting water and making hydrogen with energy from normal sunlight. Their study was recently reported in Angewandte Chemie International Edition.

It has not been possible to use visible light for photocatalysis, but our approach of combining nanostructured black phosphorus for water reduction to hydrogen and bismuth vanadate for water oxidation to oxygen lets us make use of a wide range of the solar spectrum to make hydrogen and oxygen with unprecedented efficiency,” lead author Mingshan Zhu says.

Black phosphorus has a flat, two-dimensional structure similar to that of graphene and strongly absorbs light across the whole of the visible spectrum. The researchers combined the black phosphorus with bismuth vanadate, which is a well-known water oxidation catalyst.

In the same way that plants shuttle electrons between different structures in natural photosynthesis to split water and make oxygen, the two components of this new catalyst could rapidly transfer electrons excited by sunlight. The amounts of the two components was also optimized in the catalyst, leading to production of hydrogen and oxygen gases in an ideal 2:1 ratio.

Source: http://resou.osaka-u.ac.jp/

Europe: 17 Organizations United To Produce Li-Ion Batteries

Energy storage has emerged as a central building block of the EU’s objectives in low emission electric transport and replacing electricity generated by fossil fuels with renewables. The realisation that batteries are of such strategic importance has come as a wake-up call, with Europe finding itself lagging in commercialising research in the field, and for now, completely dependent on manufacturers outside the EU for battery supplies. Public and private funders in Europe that have put €555 million into developing new energy storage technologies since 2008 have little to show for it in terms of commercial outputs.

While a number of start-ups, such as France’s NAWA Technology are working on various approaches to increasing energy density and speeding up recharging of electric vehicle batteries, none are in production. As yet, Europe has no factories producing electric vehicle batteries, though LG Chem of South Korea is currently constructing a manufacturing plant in Poland, which is due to open later this year. Another Korean manufacturer, SK Innovation, whose major customer is Mercedes-Benz, has announced it will invest $777 million to build a battery plant with capacity of 7.5 GW/year in Hungary

A European company, Northvolt is planning to build a plant in Skelleftea, northern Sweden, with construction due to start in the second half of 2018. Meanwhile, Frankfurt-based TerraE announced earlier in January that it has formed a consortium of 17 companies and research institutions to handle the planning for two large-scale lithium-ion battery cell manufacturing facilities in Germany. TerraE will build and operate the factories, where customers can have batteries produced to their own specifications.

Source: https://sciencebusiness.net/

Ultra-Thin Memory Storage For Nanocomputer

Engineers worldwide have been developing alternative ways to provide greater memory storage capacity on even smaller computer chips. Previous research into two-dimensional atomic sheets for memory storage has failed to uncover their potential — until now. A team of electrical engineers at The University of Texas at Austin, in collaboration with Peking University scientists, has developed the thinnest memory storage device with dense memory capacity, paving the way for faster, smaller and smarter computer chips for everything from consumer electronics to big data to brain-inspired computing.

For a long time, the consensus was that it wasn’t possible to make memory devices from materials that were only one atomic layer thick,” said Deji Akinwande, associate professor in the Cockrell School of Engineering’s Department of Electrical and Computer Engineering. “With our new ‘atomristors,’ we have shown it is indeed possible.”

Made from 2-D nanomaterials, the “atomristors” — a term Akinwande coined — improve upon memristors, an emerging memory storage technology with lower memory scalability. He and his team published their findings in the January issue of Nano Letters.

Atomristors will allow for the advancement of Moore’s Law at the system level by enabling the 3-D integration of nanoscale memory with nanoscale transistors on the same chip for advanced computing systems,” Akinwande said.

Memory storage and transistors have, to date, always been separate components on a microchip, but atomristors combine both functions on a single, more efficient computer system. By using metallic atomic sheets (graphene) as electrodes and semiconducting atomic sheets (molybdenum sulfide) as the active layer, the entire memory cell is a sandwich about 1.5 nanometers thick, which makes it possible to densely pack atomristors layer by layer in a plane. This is a substantial advantage over conventional flash memory, which occupies far larger space. In addition, the thinness allows for faster and more efficient electric current flow.

Given their size, capacity and integration flexibility, atomristors can be packed together to make advanced 3-D chips that are crucial to the successful development of brain-inspired computing. One of the greatest challenges in this burgeoning field of engineering is how to make a memory architecture with 3-D connections akin to those found in the human brain.

The sheer density of memory storage that can be made possible by layering these synthetic atomic sheets onto each other, coupled with integrated transistor design, means we can potentially make computers that learn and remember the same way our brains do,” Akinwande said.

Source: https://news.utexas.edu

Efficient, Low-Cost Catalyst To Produce Hydrogen

A nanostructured composite material developed at UC Santa Cruz has shown impressive performance as a catalyst for the electrochemical splitting of water to produce hydrogen. An efficient, low-cost catalyst is essential for realizing the promise of hydrogen as a clean, environmentally friendly fuel.

Researchers led by Shaowei Chen, professor of chemistry and biochemistry at UC Santa Cruz, have been investigating the use of carbon-based nanostructured materials as catalysts for the reaction that generates hydrogen from water. In one recent study, they obtained good results by incorporating ruthenium ions into a sheet-like nanostructure composed of carbon nitride. Performance was further improved by combining the ruthenium-doped carbon nitride with graphene, a sheet-like form of carbon, to form a layered composite.

The bonding chemistry of ruthenium with nitrogen in these nanostructured materials plays a key role in the high catalytic performance,” Chen said. “We also showed that the stability of the catalyst is very good.”

Currently, the most efficient catalysts for the electrochemical reaction that generates hydrogen from water are based on platinum, which is scarce and expensive. Carbon-based materials have shown promise, but their performance has not come close to that of platinum-based catalysts.

In the new composite material developed by Chen’s lab, the ruthenium ions embedded in the carbon nitride nanosheets change the distribution of electrons in the matrix, creating more active sites for the binding of protons to generate hydrogen. Adding graphene to the structure further enhances the redistribution of electrons.

The new findings were published in ChemSusChem.

Source: https://news.ucsc.edu/

Thin And Highly Insulating Walls Lower Heating Costs

Better thermal insulation means lower heating costs – but this should not be at the expense of exciting architecture. A new type of brick filled with aerogel could make thin and highly insulating walls possible in the future – without any additional insulation layer.

The calculation is simple: the better a building is insulated, the less heat is lost in winter – and the less energy is needed to achieve a comfortable room temperature. No wonder, then, that the Swiss Federal Office of Energy (SFOE) regularly raises the requirements for building insulation.

In order to achieve the same insulation values as a 165 mm thick wall of aerobricks, a wall of perlite bricks must be 263 mm thick – and a wall of non-insulating bricks even more than one meter!

Traditionally, the insulating layers are applied to the finished walls. Increasingly, however, self-insulating bricks are being used – saving both work steps and costs and opening up new architectural possibilities. Insulating bricks offer a workable compromise between mechanical and thermal properties and are also suited for multi-storey buildings. They are already available on the market in numerous models: some have multiple air-filled chambers, others have larger cavities filled with insulating materials such as pearlite, mineral wool or polystyrene. Their thermal conductivity values differ depending on the structure and filling material. In order to reach the insulation values of walls with seperate insulating layers, the insulating bricks are usually considerably thicker than normal bricks.

Empa researchers have now replaced Perlite in insulating bricks with Aerogel: a highly porous solid with very high thermal insulation properties that can withstand temperatures of up to 300°C (see box). It is not a novel material for the researchers: they have already used it to develop a high-performance insulating plaster which, among other things, allows historical buildings to be renovated energetically without affecting their appearance.

Together with his colleagues, Empa researcher Jannis Wernery from the research department «Building Energy Materials and Components» has developed a paste-like mixture of aerogel particles to be used as filler material for the brick. «The material can easily be filled into the cavities and then joins with the clay of the bricks», says Wernery. «The aerogel stays in the bricks – you can work with them as usual.» The «Aerobrick» was born.

Source: https://www.empa.ch/

Memristors Retain Data 10 Years Without Power

The internet of things ( IoT) is coming, that much we know. But still it won’t; not until we have components and chips that can handle the explosion of data that comes with IoT. In 2020, there will already be 50 billion industrial internet sensors in place all around us. A single autonomous device – a smart watch, a cleaning robot, or a driverless car – can produce gigabytes of data each day, whereas an airbus may have over 10 000 sensors in one wing alone.

Two hurdles need to be overcome. First, current transistors in computer chips must be miniaturized to the size of only few nanometres; the problem is they won’t work anymore then. Second, analysing and storing unprecedented amounts of data will require equally huge amounts of energy. Sayani Majumdar, Academy Fellow at Aalto University (Finland), along with her colleagues, is designing technology to tackle both issues.

Majumdar has with her colleagues designed and fabricated the basic building blocks of future components in what are called “neuromorphiccomputers inspired by the human brain. It’s a field of research on which the largest ICT companies in the world and also the EU are investing heavily. Still, no one has yet come up with a nano-scale hardware architecture that could be scaled to industrial manufacture and use.

The probe-station device (the full instrument, left, and a closer view of the device connection, right) which measures the electrical responses of the basic components for computers mimicking the human brain. The tunnel junctions are on a thin film on the substrate plate.

The technology and design of neuromorphic computing is advancing more rapidly than its rival revolution, quantum computing. There is already wide speculation both in academia and company R&D about ways to inscribe heavy computing capabilities in the hardware of smart phones, tablets and laptops. The key is to achieve the extreme energy-efficiency of a biological brain and mimic the way neural networks process information through electric impulses,” explains Majumdar.

In their recent article in Advanced Functional Materials, Majumdar and her team show how they have fabricated a new breed of “ferroelectric tunnel junctions”, that is, few-nanometre-thick ferroelectric thin films sandwiched between two electrodes. They have abilities beyond existing technologies and bode well for energy-efficient and stable neuromorphic computing.

The junctions work in low voltages of less than five volts and with a variety of electrode materials – including silicon used in chips in most of our electronics. They also can retain data for more than 10 years without power and be manufactured in normal conditions.

Tunnel junctions have up to this point mostly been made of metal oxides and require 700 degree Celsius temperatures and high vacuums to manufacture. Ferroelectric materials also contain lead which makes them – and all our computers – a serious environmental hazard.

Our junctions are made out of organic hydro-carbon materials and they would reduce the amount of toxic heavy metal waste in electronics. We can also make thousands of junctions a day in room temperature without them suffering from the water or oxygen in the air”, explains Majumdar.

What makes ferroelectric thin film components great for neuromorphic computers is their ability to switch between not only binary states – 0 and 1 – but a large number of intermediate states as well. This allows them to ‘memoriseinformation not unlike the brain: to store it for a long time with minute amounts of energy and to retain the information they have once received – even after being switched off and on again.

We are no longer talking of transistors, but ‘memristors’. They are ideal for computation similar to that in biological brains.  Take for example the Mars 2020 Rover about to go chart the composition of another planet. For the Rover to work and process data on its own using only a single solar panel as an energy source, the unsupervised algorithms in it will need to use an artificial brain in the hardware.

What we are striving for now, is to integrate millions of our tunnel junction memristors into a network on a one square centimetre area. We can expect to pack so many in such a small space because we have now achieved a record-high difference in the current between on and off-states in the junctions and that provides functional stability. The memristors could then perform complex tasks like image and pattern recognition and make decisions autonomously,” says Majumdar.

Source: http://www.aalto.fi/

Flat Lens Boost Virtual Reality

Metalensesflat surfaces that use nanostructures to focus light — promise to revolutionize optics by replacing the bulky, curved lenses currently used in optical devices with a simple, flat surface.  But, these metalenses have remained limited in the spectrum of light they can focus well Now a team of researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) has developed the first single lens that can focus the entire visible spectrum of light — including white light — in the same spot and in high resolution. This has only ever been achieved in conventional lenses by stacking multiple lenses.

Focusing the entire visible spectrum and white light – combination of all the colors of the spectrum — is so challenging because each wavelength moves through materials at different speeds. Red wavelengths, for example, will move through glass faster than the blue, so the two colors will reach the same location at different times resulting in different foci. This creates image distortions known as chromatic aberrations.

Cameras and optical instruments use multiple curved lenses of different thicknesses and materials to correct these aberrations, which, of course, adds to the bulk of the device.

Metalenses have advantages over traditional lenses,” says Federico Capasso, Professor of Applied Physics at SEAS and senior author of the research. “Metalenses are thin, easy to fabricate and cost effective. This breakthrough extends those advantages across the whole visible range of light. This is the next big step. Using our achromatic lens, we are able to perform high quality, white light imaging. This brings us one step closer to the goal of incorporating them into common optical devices such as cameras“.

The research is published in Nature Nanotechnology.

Source: https://www.seas.harvard.edu/

Fabric Made Of Nanofibers With Embedded OLED

In South Korea, Professor Kyung Cheol Choi from the School of Electrical Engineering (KAIST)  and his team succeeded in fabricating highly efficient Organic Light-Emitting Diodes (OLEDs) on an ultra-thin fiber. The team expects the technology, which produces high-efficiency, long-lasting OLEDs, can be widely utilized in wearable displays. Existing fiber-based wearable displays’ OLEDs show much lower performance compared to those fabricated on planar substrates. This low performance caused a limitation for applying it to actual wearable displays.

In order to solve this problem, the team designed a structure of OLEDs compatible to fiber and used a dip-coating method in a three-dimensional structure of fibers. Through this method, the team successfully developed efficient OLEDs that are designed to last a lifetime and are still equivalent to those on planar substrates.
The team identified that solution process planar OLEDs can be applied to fibers without any reduction in performance through the technology. This fiber OLEDs exhibited luminance and current efficiency values of over 10,000 cd/m^2(candela/square meter) and 11 cd/A (candela/ampere).
The team also verified that the fiber OLEDs withstood tensile strains of up to 4.3% while retaining more than 90% of their current efficiency. In addition, they could be woven into textiles and knitted clothes without causing any problems.Moreover, the technology allows for fabricating OLEDs on fibers with diameters ranging from 300㎛ down to 90㎛, thinner than a human hair, which attests to the scalability of the proposed fabrication scheme.
Noting that every process is carried out at a low temperature (~105℃), fibers vulnerable to high temperatures can also employ this fabrication scheme.
Professor Choi said, “Existing fiber-based wearable displays had limitations for applicability due to their low performance. However, this technology can fabricate OLEDs with high performance on fibers. This simple, low-cost process opens a way to commercialize fiber-based wearable displays.”
Source: http://www.kaist.edu/

How Nanotechnology Can Help Heal Hearts

Nanotechnology is especially suited to medicine because nature operates at not even a micro, but a nano scale synapses, the extracellular spaces between neurons that exchange massive amounts of information per second are approximately only 20-40 nanometres (nm) wide. The typical largest coronary artery, which supplies oxygen-rich blood to the heart, barely measures an inch in diameter.

Nanotechnology works with this natural nanoscale to deliver better healthcare results with fewer risks and side effects in a shorter span of time. It uses finer instruments, minimally invasive procedures and more efficient drug delivery systems to unblock blood vessels and repair tissues. This aspect of nanotechnology is especially useful and can reduce the risks associated with many invasive procedures, including cardiac care protocols.

Angioplasty is a procedure to open narrowed or blocked coronary arteries, which supply blood to the heart. During an angioplasty, a balloon catheter is guided into the affected artery; the balloon may be ‘blown up’ a few times to widen the diameter of the artery. Often a coronary artery stent, a small, metal mesh tube that expands inside the artery, is placed during or immediately after angioplasty to help prevent the artery from closing up again. A drug-eluting stent, now the norm, has medicine embedded in it that helps prevent the artery from closing in the long-term.

So far, so good. But this is where we run into a hiccup.  One of the biggest problems with current drug-eluting stents is Paclitaxel, the very drug they carry. Clinical trials show toxicity associated with Paclitaxel and increased chances of thrombosis, a dangerous event linked with heart attacks and strokes. Cardiologists remain conflicted over the use of Paclitaxel. A possible solution to Paclitaxel could be an alternate, safer drug, which is small enough at the molecular level to be bioavailable and can also be introduced in the artery in a short span of 35-40 seconds. Keep the stent in the artery any longer than this razor-thin span and you risk complications. Sirolimous is one such drug, but the biggest problem with Sirolimous is that it is slow on the uptake.

It took years of research by a dedicated core team of doctors, surgeons, pharmacists and chemists to finally put together the puzzle. And when all the pieces locked in place, the answer was perfect in its simplicity – a nanotechnology-enabled polymer-free drug-eluting stent system, especially adapted to carry Sirolimous, a far safer and hypoallergenic drug than Paclitaxel.

Source: https://yourstory.com/

How To Turn Nitrates Into Water And Air

Engineers at Rice University’s Nanotechnology Enabled Water Treatment (NEWT) Center have found a catalyst that cleans toxic nitrates from drinking water by converting them into air and water.

Nitrates come mainly from agricultural runoff, which affects farming communities all over the world,” said Rice chemical engineer Michael Wong, the lead scientist on the study. “Nitrates are both an environmental problem and health problem because they’re toxic. There are ion-exchange filters that can remove them from water, but these need to be flushed every few months to reuse them, and when that happens, the flushed water just returns a concentrated dose of nitrates right back into the water supply.”

Wong’s lab specializes in developing nanoparticle-based catalysts, submicroscopic bits of metal that speed up chemical reactions. In 2013, his group showed that tiny gold spheres dotted with specks of palladium could break apart nitrites, the more toxic chemical cousins of nitrates.

Nitrates are molecules that have one nitrogen atom and three oxygen atoms,” Wong explained. “Nitrates turn into nitrites if they lose an oxygen, but nitrites are even more toxic than nitrates, so you don’t want to stop with nitrites. Moreover, nitrates are the more prevalent problem. Ultimately, the best way to remove nitrates is a catalytic process that breaks them completely apart into nitrogen and oxygen, or in our case, nitrogen and water because we add a little hydrogen, he said”. “More than 75 percent of Earth’s atmosphere is gaseous nitrogen, so we’re really turning nitrates into air and water.

Nitrates are toxic to infants and pregnant women and may also be carcinogenic. Nitrate pollution is common in agricultural communities, especially in the U.S. Corn Belt and California’s Central Valley, where fertilizers are heavily used, and some studies have shown that nitrate pollution is on the rise due to changing land-use patterns.

Both nitrates and nitrites are regulated by theEnvironmental Protection Agency, which sets allowable limits for safe drinking water. In communities with polluted wells and lakes, that typically means pretreating drinking water with ion-exchange resins that trap and remove nitrates and nitrites without destroying them.

The research is available online in the American Chemical Society journal ACS Catalysis.

Source: http://news.rice.edu/

New Robust Oilseed Crop Resists Drought

University of Copenhagen (Denmark) and the global player Bayer CropScience have successfully developed a new oilseed crop that is much more resistant to heat, drought and diseases than oilseed rape. The breakthrough is big and it will feature as cover story of the April issue of Nature Biotechnology.

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Oilseed rape does not grow very well in warm and dry areas. We are very happy that we have succeeded in using a groundbreaking technology on a mustard plant, which is a close relative to rape. The result is an oilseed crop with improved agronomic traits that is tolerant to global warming. The new crop will enable cultivation in areas that today is not suitable for oilseed crops, such as the Western part of Canada, parts of Eastern Europe, Australia and India”, explains Professor Barbara Ann Halkier, Head of DynaMo Center of Excellence, University of Copenhagen, is one of the scientists who has worked on developing a new oilseed crop with better properties.

The mustard plant is similar to oilseed rape in many ways. It looks like a rape plant and its oil has the same attractive features with high content of mono– and polyunsaturated fatty acids e.g. omega-3 and -6 plus antioxidants and vitamins. However, it is also a lot more robust when grown under arid conditions and upon exposure to diseases. Mustard is therefore an obvious candidate to replace oilseed rape.

Until now it has been an undefeatable challenge that mustard seeds are full of the bitter defense compounds that give mustard its characteristic flavor. Consequently, the protein-rich seed meal that remains after the oil is pressed out of the seeds is useless as animal feed,” adds Barbara Ann Halkier.

In close collaboration with Bayer CropScience – one of the major global players within plant biotechnology and breeding – she and other scientists from the DynaMo Center have found an original solution to this problem.

Source: http://news.ku.dk/

Alcohol Damages DNA In Stem Cells

Scientists have shown how alcohol damages DNA in stem cells, which may help to explain how drinking alcohol is linked to an increased risk of cancer, according to research led by scientists from the MRC Laboratory of Molecular Biology (UK)  and part-funded by Cancer Research UK. Much previous research looking at the precise ways in which alcohol causes cancer has been done in cell cultures. But in this study, published in Nature, researchers used mice to show how alcohol exposure leads to permanent genetic damage.

The scientists gave diluted alcohol, chemically known as ethanol, to mice. They then used chromosome analysis and DNA sequencing to examine the genetic damage caused by acetaldehyde, a harmful chemical produced when the body processes alcohol. They found that acetaldehyde can break and damage DNA within blood stem cells leading to rearranged chromosomes and permanently altering the DNA sequences within these cells. It is important to understand how the DNA blueprint within stem cells is damaged, because when healthy stem cells become faulty they can give rise to cancer.

Some cancers develop due to DNA damage in stem cells. While some damage occurs by chance, our findings suggest that drinking alcohol can increase the risk of this damage,” said Professor Ketan Patelopens in new window, lead author of the study and scientist, part-funded by Cancer Research UK, at the MRC Laboratory of Molecular Biology.

The study also examined how the body tries to protect itself against damage caused by alcohol. The first line of defence is a family of enzymes called aldehyde dehydrogenases (ALDH). These enzymes break down harmful acetaldehyde into acetate, which our cells can use as a source of energy.

Worldwide, millions of people, particularly those from South East Asia, either lack these enzymes or carry faulty versions of them. So, when they drink, acetaldehyde builds up which causes a flushed complexion, and also leads to them feeling unwell.

In the study, when mice lacking the critical ALDH enzyme ALDH2 – were given alcohol, it resulted in four times as much DNA damage in their cells compared to mice with the fully functioning ALDH2 enzyme.

Source: https://www.mrc.ac.uk/

Nano-based Chip Detects Explosives

Technical University of Denmark (DTU) is ready with a prototype for a chemical “sniffer system” for the detection of criminal substances like narcotics and explosivesDogs have an eminent sense of smell. Their snouts use a specific sniffing technique which almost grabs hold of scents. Elephants’ snouts are even better than those of dogs, but obviously these are attached to elephants which are difficult to carry around. Consequently, today dogs are employed to track narcotics, money and explosives. Sometimes dogs are able to sense explosives in very small doses, however, they are not always 100 percent reliable as they are also sensitive to changes in their surroundings. A technological solution is therefore to be preferred in the tracking of stocks of narcotics or explosive materials.

Researchers at DTU have developed the prototype of a chip able to sniff molecular structures from a number of known substances. A special camera visualises the results from the chip (with 24 megapixels per 15 second) and newly developed software interprets these images according to changes in colour (i.e. the difference between two pictures), caused by the impact of the scents in the air.

We have conducted experiments by sucking air from smaller containers like e.g. handbags or pieces of luggage and from large industrial sized containers typically used for smuggling. In both cases, we arrived at promising results”, says Mogens Havsteen Jakobsen, Senior Researcher at DTU Nanotech.

By using the so-called colorimetric sensing technique, the artificial nose is able to detect different substances like explosives, narcotics, the ripeness of cheese, rotten meat and fish, the quality of wine and coffee or bad indoor climate of a room.

The project has specifically targeted explosives which are a growing safety risk in our society. The Chemical Division of the Danish Emergency Management Agency has been an important collaborator because they are authorised to produce and handle explosives. “We have test laboratories which have been made available during the course of the project”, says Jesper Mogensen, civil engineer and analysis chemist at the Chemical Division and therefore used to handling explosives.

There will be some evident advantages in using a technology such as CRIM-TRACK, compared to the instruments available today,” Jesper Mogensen says. “Firstly, the preparation time is short in that what you largely need to do is switch on the tracker and use it. This is valuable time saved. Secondly and perhaps the most important advantage is the fact that the EOD (the Explosive Ordnance Disposal) does not need to collect a sample. Today when we are called to a ransacking if e.g. a kilo of white powder has been found and we have to analyse its chemistry by way of GC-MS (i.e. gas chromatography-mass spectrometry), a sample of the substance must be collected on a fibre. In other words, it is necessary to collect physically a sample with all the risks this entails. With DTU’s sniffer system, it is possible to collect samples in the air. It sniffs for the drug much like a dog and indicates whether there are any explosives or not. This will increase the safety of our EOD”.

Source: http://www.nanotech.dtu.dk/

How To Detect Cancer With a Urine Test

Researchers centered at Nagoya University (Japan) develop a nanowire device able to detect microscopic levels of urinary markers potentially implicated in cancerCells communicate with each other through a number of different mechanisms. Some of these mechanisms are well-known: in animals, for example, predatory threats can drive the release of norepinephrine, a hormone that travels through the bloodstream and triggers heart and muscle cells to initiate a “fight-or-flight” response. A far less familiar mode of cellular transport is the extracellular vesicle (EV). EVs can be thought of as small “chunks” of a cell that are able to pinch off and circulate throughout the body to deliver messenger cargo to other cells. These messengers have become increasingly recognized as crucial mediators of cell-to-cell communication.

In a new study reported in Science Advances, researchers centered at Nagoya University have developed a novel medical device that can efficiently capture these EVs, and potentially use them to screen for cancer.

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EVs are potentially useful as clinical markers. The composition of the molecules contained in an EV may provide a diagnostic signature for certain diseases,” lead author Takao Yasui explains. “The ongoing challenge for physicians in any field is to find a non-invasive diagnostic tool that allows them to monitor their patients on a regular basis–for example, a simple urine test.”

Among the many molecules EVs have been found to harbor are microRNAs, which are short pieces of ribonucleic acid that play diverse roles in normal cellular biology. Critically, the presence of certain microRNAs in urine might serve as a red flag for serious conditions such as bladder and prostate cancer. While this important cargo could therefore theoretically aid physicians in cancer diagnoses, there are still many technological hurdles that need to be overcome. One such hurdle: finding a feasible method to capture EVs in sufficient quantities to analyze them in a routine clinical setting.

The content of EVs in urine is extremely low, at less than 0.01% of the total fluid volume. This is a major barrier to their diagnostic utility,” Yasui notes. “Our solution was to embed zinc oxide nanowires into a specialized polymer to create a material that we believed would be highly efficient at capturing these vesicles. Our findings suggest that the device is indeed quite efficient. We obtained a collection rate of over 99%, surpassing ultracentrifugation as well as other methods that are currently being used in the field.

Source: http://en.nagoya-u.ac.jp/

In 2025 Humanity Could Benefit From A Major New Source Of Clean Power

An international project to generate energy from nuclear fusion has reached a key milestone, with half of the infrastructure required now built. Bernard Bigot, the director-general of the International Thermonuclear Experimental Reactor (Iter), the main facility of which is based in southern France, said the completion of half of the project meant the effort was back on track, after a series of difficulties. This would mean that power could be produced from the experimental site from 2025.

Nuclear fusion occurs when two atoms combine to form a new atom and a neutron. The atoms are fired into a plasma where extreme temperatures overcome their repulsion and forces them together. The fusion releases about four times the energy produced when an atom is split in conventional nuclear fission

The effort to bring nuclear fusion power closer to operation is backed by some of the world’s biggest developed and emerging economies, including the EU, the US, China, India, Japan, Korea and Russia. However, a review of the long-running project in 2013 found problems with its running and organisation. This led to the appointment of Bigot, and a reorganisation that subsequent reviews have broadly endorsed.

Fusion power is one of the most sought-after technological goals in the pursuit of clean energy. Nuclear fusion is the natural phenomenon that powers the sun, converting hydrogen into helium atoms through a process that occurs at extreme temperatures.

Replicating that process on earth at sufficient scale could unleash more energy than is likely to be needed by humanity, but the problem is creating the extreme conditions necessary for such reactions to occur, harnessing the resulting energy in a useful way, and controlling the reactions once they have been induced.

The Iter project aims to use hydrogen fusion, controlled by large superconducting magnets, to produce massive heat energy which would drive turbines – in a similar way to the coal-fired and gas-fired power stations of today – that would produce electricity. This would produce power free from carbon emissions, and potentially at low cost, if the technology can be made to work at a large scale.

For instance, according to Iter scientists, an amount of hydrogen the size of a pineapple could be used to produce as much energy as 10,000 tonnes of coal.

Source: https://www.theguardian.com/

Nano-based Air Purifier Destroys Pollutants

Molekule, a San Francisco-based startup with a sleekly designed molecular air purifier started as an immigrant dream twenty years ago and ended up being named one of Time’s top 25 inventions of 2017. The inventor Yogi Goswami came up with the idea when his baby son Dilip started having a hard time breathing the air around him. Dilip suffered from severe asthma but no air purifier at the time seemed to work well enough to clean up indoor pollutants. Traditional HEPA filters simply trap a few pollutants but they don’t grab everything and they don’t break them down before releasing them back into the air.

So, Goswami the elder came up with a filter technology that could both suck up things like allergens, mold and bacteria and particles up to one-thousand times smaller than what a HEPA filter can catch using photo electrochemical oxidation (PECO) and nanotechnology to destroy the pollutants on a molecular level and eliminate the full spectrum of indoor air pollutants. The result? Clean, breathable air that even the most sensitive person can handle. Dilip and his sister Jaya Goswami patented the tech and founded Molekule to bring their father’s invention to the rest of us.

The company now ships a stylish $800, two-foot-tall cylinder with the patented filter inside. Sure, it’s a lot pricier than most filters out there but the company also offers financing at $67 a month. It was also instrumental in helping folks breathe during the Northern California wildfires this fall. Jaya mentioned Molekule’s inventory was completely depleted during that time and that the company couldn’t ship fast enough — the product is still backordered till January 3rd, 2018. So far Molekule has brought in just over $13 million in venture funding to keep it going.

Source: https://molekule.com/#
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How To Store Solar Energy In A Non-Electric Battery

Materials chemists have been trying for years to make a new type of battery that can store solar or other light-sourced energy in chemical bonds rather than electrons, one that will release the energy on demand as heat instead of electricity–addressing the need for long-term, stable, efficient storage of solar power.

Now a group of materials chemists at the University of Massachusetts Amherst led by Dhandapani Venkataraman, with Ph.D. student and first author Seung Pyo Jeong, Ph.D. students Larry Renna, Connor Boyle and others, report that they have solved one of the major hurdles in the field by developing a polymer-based system. It can yield energy storage density – the amount of energy stored – more than two times higher than previous polymer systems. Details appear in the current issue of Scientific Reports.

Venkataraman and Boyle say that previous high energy storage density achieved in a polymeric system was in the range of 200 Joules per gram, while their new system is able to reach an average of 510 Joules per gram, with a maximum of 690. Venkataraman says, “Theory says that we should be able to achieve 800 Joules per gram, but nobody could do it. This paper reports that we’ve reached one of the highest energy densities stored per gram in a polymeric system, and how we did it.”

Source: https://www.umass.edu/

Inflammation, Key For The Progression of Alzheimer’s

According to a study by scientists of the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn now published in the journal “Nature”, inflammatory mechanisms caused by the brain’s immune system drive the progression of Alzheimer’s disease. These findings, which rely on a series of laboratory experiments, provide new insights into pathogenetic mechanisms that are believed to hold potential for tackling Alzheimer’s before symptoms manifest. The researchers envision that one day this may lead to new ways of treatment. Further institutions both from Europe and the US also contributed to the current results.

Alzheimer’s disease is a devastating neurodegenerative condition ultimately leading to dementia. An effective treatment does not yet exist. The disease is associated with the aberrant aggregation of small proteins called “Amyloid-beta” () that accumulate in the brain and appear to harm neurons. In recent years, studies revealed that deposits of , known as “plaques”, trigger inflammatory mechanisms by the brain’s innate immune system. However, the precise processes that lead to neurodegeneration and progression of pathology have thus far not been fully understood.

Deposition and spreading of Aβ pathology likely precede the appearance of clinical symptoms such as memory problems by decades. Therefore, a better understanding of these processes might be a key for novel therapeutic approaches. Such treatments would target Alzheimer’s at an early stage, before cognitive deficits manifest,” says Prof. Michael Heneka, a senior researcher at the DZNE and Director of the Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn.

Prof. Heneka, who is also involved in the cluster of excellence “ImmunoSensation” at the University of Bonn, and coworkers have been investigating the role of the brain’s immune response in the progression of Aβ pathology for some time already. Previous work by the group that was published in Nature in 2013, had established that the molecular complex NLRP3, which is an innate immune sensor, is activated in brains of Alzheimer’s patients and contributes to the pathogenesis of Alzheimer’s in the murine model. NLRP3 is a so-called inflammasome that triggers production of highly pro-inflammatory cytokines. Furthermore, upon activation, NLRP3 forms large signaling complexes with the adapter protein ASC, which are called “ASC specks” that can be released from cells. “The release of ASC specks from activated cells has so far only been documented in macrophages and their relevance in disease processes has so far remained a mystery,” says Prof. Eicke Latz, director of the Institute of Innate Immunity and member of the cluster of excellence “ImmunoSensation” at the University of Bonn.

Source: https://www.uni-bonn.de

Virgin Hyperloop One’s System Over 240 mph (387 km/h)

In a recent test, Virgin Hyperloop One‘s system beat all previous speed records, hitting nearly 387 kilometers per hour (240 miles per hour). With Richard Branson now in their corner, the company could dominate the future of hyperloop transportation. On December 18, Virgin Hyperloop One announced the completion of third phase testing on the DevLoop, the world’s first full-scale hyperloop test site. During these tests, the system clocked a lightning-fast speed of nearly 387 kmh (240 mph), breaking the 355 kmh (220 mph) hyperloop speed record set by Elon Musk’s hyperloop in August.

During this phase of testing, the company experimented with using a new airlock that helps test pods transition between atmospheric and vacuum conditions. By combining magnetic levitation, extremely low aerodynamic drag, and the level of air pressure experienced at 200,000 feet above sea level, the system proved that it is capable of reaching airline speeds over long distances.

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The recent phase three testing continues to prove the incredible persistence and determination of our DevLoop team — the close to 200 engineers, machinists, welders, and fabricators who collaborated to make hyperloop a reality today,” Josh Giegel, Virgin Hyperloop One’s co-founder and chief technology officer, stated in a press release announcing the new hyperloop speed record.

Source: https://hyperloop-one.com/

Gilded fuel cells boost electric car efficiency

To make modern-day fuel cells less expensive and more powerful, a team led by Johns Hopkins chemical engineers has drawn inspiration from the ancient Egyptian tradition of gilding. Egyptian artists at the time of King Tutankhamun often covered cheaper metals (copper, for instance) with a thin layer of a gleaming precious metal such as gold to create extravagant masks and jewelry. In a modern-day twist, the Johns Hopkins-led researchers have applied a tiny coating of costly platinum just one nanometer thick—100,000 times thinner than a human hair—to a core of much cheaper cobalt. This microscopic marriage could become a crucial catalyst in new fuel cells that generate electric current to power cars and other machines.

The new fuel cell design would save money because it would require far less platinum, a very rare and expensive metal that is commonly used as a catalyst in present-day fuel-cell electric cars. The researchers, who published their work earlier this year in Nano Letters, say that by making electric cars more affordable, this innovation could curb the emission of carbon dioxide and other pollutants from gasoline– or diesel-powered vehicles.

This technique could accelerate our launch out of the fossil fuel era,” said Chao Wang, a Johns Hopkins assistant professor in the Department of Chemical and Biomolecular Engineering and senior author of the study. “It will not only reduce the cost of fuel cells. It will also improve the energy efficiency and power performance of clean electric vehicles powered by hydrogen.”

In their journal article, the authors tipped their hats to the ancient Egyptian artisans who used a similar plating technique to give copper masks and other metallic works of art a lustrous final coat of silver or gold.The idea,” Wang said, “is to put a little bit of the precious treasure on top of the cheap stuff.”

He pointed out that platinum, frequently used in jewelry, also is a critical material in modern industry. It catalyzes essential reactions in activities including petroleum processing, petrochemical synthesis, and emission control in combustion vehicles, and is used in fuel cells. But, he said, platinum’s high cost and limited availability have made its use in clean energy technologies largely impractical—until now.

Source: https://hub.jhu.edu/

AI Machine Beats Champion Chess Program


AlphaZero
, the game-playing AI created by Google sibling DeepMind, has beaten the world’s best chess-playing computer program, having taught itself how to play in under four hours. The repurposed AI, which has repeatedly beaten the world’s best Go players as AlphaGo, has been generalised so that it can now learn other games. It took just four hours to learn the rules to chess before beating the world champion chess program, Stockfish 8, in a 100-game match up. AlphaZero won or drew all 100 games, according to a non-peer-reviewed research paper published with Cornell University Library’s arXiv.

CLICK ON THE IMAGE AND SEE ALPHA ZERO DEVOURING  STOCKFISH

Starting from random play, and given no domain knowledge except the game rules, AlphaZero achieved within 24 hours a superhuman level of play in the games of chess and shogi [a similar Japanese board game] as well as Go, and convincingly defeated a world-champion program in each case,” said the paper’s authors that include DeepMind founder Demis Hassabis, who was a child chess prodigy reaching master standard at the age of 13.

“It’s a remarkable achievement, even if we should have expected it after AlphaGo,” former world chess champion Garry Kasparov told Chess.com. “We have always assumed that chess required too much empirical knowledge for a machine to play so well from scratch, with no human knowledge added at all.

Computer programs have been able to beat the best human chess players ever since IBM’s Deep Blue supercomputer defeated Kasparov on 12 May 1997DeepMind said the difference between AlphaZero and its competitors is that its machine-learning approach is given no human input apart from the basic rules of chess. The rest it works out by playing itself over and over with self-reinforced knowledge. The result, according to DeepMind, is that AlphaZero took an “arguably more human-like approach” to the search for moves, processing around 80,000 positions per second in chess compared to Stockfish 8’s 70m.

After winning 25 games of chess versus Stockfish 8 starting as white, with first-mover advantage, a further three starting with black and drawing a further 72 games, AlphaZero also learned shogi in two hours before beating the leading program Elmo in a 100-game matchup. AlphaZero won 90 games, lost eight and drew 2. The new generalised AlphaZero was also able to beat the “super human” former version of itself AlphaGo at the Chinese game of Go after only eight-hours of self-training, winning 60 games and losing 40 games.

While experts said the results are impressive, and have potential across a wide-range of applications to complement human knowledge, professor Joanna Bryson, a computer scientist and AI researcher at the University of Bath, warned that it was “still a discrete task“.

Source: https://www.theguardian.com/

Drug lowers deadly Huntington’s disease protein

The first drug targeting the cause of Huntington’s disease was safe and well-tolerated in its first human trial led by UCL (UK) scientists. It successfully lowered the level of the harmful huntingtin protein in the nervous system. After over a decade in pre-clinical development, this first human trial of huntingtin-lowering drug began in late 2015, led by Professor Sarah Tabrizi (UCL Institute of Neurology) and sponsored by Ionis Pharmaceuticals.

The trial involved enrolling 46 patients with early Huntington’s disease at nine study centres in the UK, Germany and Canada. Each patient received four doses of either IONIS-HTTRx or placebo, given by injection into the spinal fluid to enable it to reach the brain. As the phase 1/2a trial progressed, the dose of IONIS-HTTRx was increased several times according to the ascending-dose trial design. Patient safety was monitored throughout the study by an independent safety committee. Today’s announcement at completion of the trial confirms that IONIS-HTTRx was well-tolerated by the trial participants and its safety profile supports further testing in patients.

The results of this trial are of ground-breaking importance for Huntington’s disease patients and families. For the first time a drug has lowered the level of the toxic disease-causing protein in the nervous system, and the drug was safe and well-tolerated. The key now is to move quickly to a larger trial to test whether the drug slows disease progression

Source: http://www.ucl.ac.uk/

Nobel Prize Nanotechnologist Launches His Own Anti-Aging Cosmetic Line

In 2016, J. Fraser Stoddart won the Nobel Prize in Chemistry for his part in designing a molecular machine. Now as chief technology officer and cofounder of nanotechnology firm PanaceaNano, he has introduced the “Noble” line of antiaging cosmetics, including a $524 formula described as an “anti-wrinkle repair” night cream. The firm says the cream contains Nobel Prize-winning “organic nano-cubes” loaded with ingredients that reverse skin damage and reduce the appearance of wrinkles. Other prize-winning chemists have founded companies, but Stoddart’s backing of the antiaging cosmetic line takes the promotion of a new company by an award-winning scientist to the next level.

The nano-cubes are made of carbohydrate molecules known as cyclodextrins. The cubes, of various sizes and shapes, release ingredients such as vitamins and peptides onto the skin “at predefined times with molecular precision,” according to the Noble skin care website. PanaceaNano cofounder Youssry Botros, former nanotechnology research director at Intel, contends that the metering technology makes the product line “far superior to comparable products in the market today.” However, the nanocubes aren’t molecular machines, for which Stoddart won his Nobel prize.

While acknowledging the product line trades on his Nobel prize, Stoddart points out that “we’re not spelling our product name, Noble, the way the Swedish Nobel Foundation does.Ethicist Michael Kalichman has a different perspective. Use of the word Noble, even though spelled differently than the prize, is “unseemly but not illegal,” he says. Kalichman, who is director of the Research Ethics Program at the University of California, San Diego, adds, “If his goal is to make money, this may work. But if his goal is to retain credibility and pursue other more laudable goals, maybe he should stay focused on those goals.”

Botros says PanaceaNano is also developing nanotechnology materials for markets including hydrogen storage, flexible batteries, and molecular memory based on technology from Stoddart’s lab and licensed from Northwestern University. But PanaceaNano chose to make its first commercial product a line of cosmetics because of the high margins and the ease of market entry.

Source: https://cen.acs.org/

DNA Origami, The New Revolution To Come For Nanotechnology

For the past few decades, some scientists have known the shape of things to come in nanotechnology is tied to the molecule of life, DNA. This burgeoning field is called “DNA origami.” The moniker is borrowed from the art of conjuring up birds, flowers and other shapes by imaginatively folding a single sheet of paper. Similarly, DNA origami scientists are dreaming up a variety of shapes — at a scale one thousand times smaller than a human hair — that they hope will one day revolutionize computing, electronics and medicine. Now, a team of Arizona State University and Harvard scientists has invented a major new advance in DNA nanotechnology. Dubbed “single-stranded origami” (ssOrigami), their new strategy uses one long noodle-like strand of DNA, or its chemical cousin RNA, that can self-fold — without even a single knot — into the largest, most complex structures to date. And the strands forming these structures can be made inside living cells or using enzymes in a test tube, allowing scientists the potential to plug-and-play with new designs and functions for nanomedicine: picture tiny nanobots playing doctor and delivering drugs within cells at the site of injury.

A DNA origami with an emoji-like smiley face

I think this is an exciting breakthrough, and a great opportunity for synthetic biology as well,” said Hao Yan, a co-inventor of the technology, director of the ASU Biodesign Institute’s Center for Molecular Design and Biomimetics, and the Milton Glick Professor in the School of Molecular Sciences.

We are always inspired by nature’s designs to make information-carrying molecules that can self-fold into the nanoscale shapes we want to make,” he said.

As proof of concept, they’ve pushed the envelope to make 18 shapes, including emoji-like smiley faces, hearts and triangles, that significantly expand the design studio space and material scalability for so-called, “bottom-upnanotechnology.

Source: https://asunow.asu.edu/

The Smell Of Death

Scientists in Korea have developed a bioelectronicnose’ that can specifically detect a key compound produced in decaying substances. When food begins to rot, the smell that we find repulsive comes from a compound known as cadaverine. That is also the substance responsible for the stench of rotting bodies, or cadavers—hence the name. The compound is the result of a bacterial reaction involving lysine, which is an amino acid commonly found in various food products. A previous study has shown that a receptor in zebrafish has an affinity for cadaverine. To make this receptor in the laboratory, scientists have turned to Escherichia coli bacteria as a host cell because it can easily produce large quantities of proteins. However, the production of this receptor in E. coli has been a challenge because it needs to be embedded in a membrane.

In this study, a team of researchers led by Associate Professor Hong Seunghun at Seoul National University packaged the cadaverine receptor from the zebrafish into nanodiscs, which are water friendly, membrane-like structures. The researchers then placed the receptor-containing nanodiscs in a special orientation on a carbon nanotube transistor, completing the bioelectronic nose. During testing with purified test compounds and real-world salmon and beef samples, the nose was selective and sensitive for cadaverine, even at low levels. The researchers suggest that the detector could someday prove useful in natural disaster scenarios, to recover corpses for identification.

The findings have been published in the journal ACS Nano.

Source: http://pubs.acs.org/

Paraplegic Rats Walk After Stem Cell Treatment

Engineered tissue containing human stem cells has allowed paraplegic rats to walk independently and regain sensory perception. The implanted rats also show some degree of healing in their spinal cords. The research, published in Frontiers in Neuroscience, demonstrates the great potential of stem cellsundifferentiated cells that can develop into numerous different types of cells—to treat spinal cord injury.

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Spinal cord injuries often lead to paraplegia. Achieving substantial recovery following a complete tear, or transection, is an as-yet unmet challenge.

Led by Dr. Shulamit Levenberg, of the Technion-Israel Institute of Technology, the researchers implanted human stem cells into rats with a complete spinal cord transection. The stem cells, which were derived from the membrane lining of the mouth, were induced to differentiate into support cells that secrete factors for neural growth and survival.

The work involved more than simply inserting stem cells at various intervals along the spinal cord. The research team also built a three-dimensional scaffold that provided an environment in which the stem cells could attach, grow and differentiate into support cells. This engineered tissue was also seeded with human thrombin and fibrinogen, which served to stabilize and support neurons in the rat’s spinal cord.

Rats treated with the engineered tissue containing stem cells showed higher motor and sensory recovery compared to control rats. Three weeks after introduction of the stem cells, 42% of the implanted paraplegic rats showed a markedly improved ability to support weight on their hind limbs and walk. 75% of the treated rats also responded to gross stimuli to the hind limbs and tail.

In contrast, control paraplegic rats that did not receive showed no improved mobility or sensory responses.

In addition, the lesions in the spinal cords of the treated rats subsided to some extent. This indicates that their spinal cords were healing.

Source: https://medicalxpress.com/

Flying MotorBikes For Dubai Police

Dubai Police, already home to Lamborghini patrol cars and android officers, has decided to take to the skies in what can only be described as a flying motorbike.

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The vehicle, called the Scorpion and designed by Russian tech company Hoversurf, relies on four propellers to stay airborne, with the rider crouched precariously close to the exposed blades. Capable of 40 mph and a travel time of 25 minutes, the single-seat craft, which can carry 600 lbs, can also operate autonomously.

After appearing at tech shows earlier this year, Dubai Police has decided to add one to its list of cutting-edge gadgets, all part of the force’s “smart city” plans.

Unveiled at Dubai’s Gitex Technology show, the Scorpion was presented alongside a new electric motorbike concept by Japanese firm Mikasa — firmly rooted to the ground, but with a top speed of 124 mph according to the police and looking like something out of the film “Tron.”
Source: http://edition.cnn.com/

Lenses Provide Nano Scale X-ray Microscopy

Scientists at DESY (Germany) have developed novel lenses that enable X-ray microscopy with record resolution in the nanometre regime. Using new materials, the research team led by DESY scientist Saša Bajt from the Center for Free-Electron Laser Science (CFEL) has perfected the design of specialised X-ray optics and achieved a focus spot size with a diameter of less than ten nanometres. A nanometre is a millionths of a millimetre and is smaller than most virus particles. They successfully used their lenses to image samples of marine plankton.

Modern particle accelerators provide ultra-bright and high-quality X-ray beams. The short wavelength and the penetrating nature of X-rays are ideal for the microscopic investigation of complex materials. However, taking full advantage of these properties requires highly efficient and almost perfect optics in the X-ray regime. Despite extensive efforts worldwide this turned out to be more difficult than expected, and achieving an X-ray microscope that can resolve features smaller than 10 nm is still a big challenge.

 

The silica shell of the diatom Actinoptychus senarius, measuring only 0.1 mm across, is revealed in fine detail in this X-ray hologram recorded at 5000-fold magnification with the new lenses. The lenses focused an X-ray beam to a spot of approximately eight nanometres diameter – smaller than a single virus – which then expanded to illuminate the diatom and form the hologram

The new lenses consist of over 10 000 alternating layers of a new material combination, tungsten carbide and silicon carbide. “The selection of the right material pair was critical for the success,” emphasises Bajt. “It does not exclude other material combinations but it is definitely the best we know now.” The resolution of the new lenses is about five times better than achievable with typical state-of-the-art lenses.

We produced the world’s smallest X-ray focus using high efficiency lenses,” says Bajt. The new lenses have an efficiency of more than 80 per cent. This high efficiency is achieved with the layered structures that make up the lens and which act like an artificial crystal to diffract X-rays in a controlled way.

The researchers have reported their work in the journal Light: Science and Applications.

Source: http://www.desy.de/

Budweiser Orders 40 Tesla Electric Trucks

The list of companies placing orders for Tesla Semi electric trucks keeps growing weeks after the unveiling event last month. Now Anheuser-Busch, the brewer behind Budweiser, announced that it ordered 40 Tesla Semi trucks. Last week, DHL confirmed an order of 10 trucks – bringing the tally to just over 200 Tesla Semi trucks. The brewer says that it will include the electric trucks in its distribution network as part of its commitment to reduce its operational carbon footprint by 30 percent by 2025. Considering the size of their distribution network, they say that it would be the equivalent of removing nearly 500,000 cars from the road globally each year.

At Anheuser-Busch, we are constantly seeking new ways to make our supply chain more sustainable, efficient, and innovative. This investment in Tesla semi-trucks helps us achieve these goals while improving road safety and lowering our environmental impact,” commented James Sembrot, Senior Director of Logistics Strategy.

Tesla Semi is actually only one part of Anheuser-Busch’s effort to modernize its fleet. They also confirmed orders from Nikola Motors for their battery/fuel cell hydrogen trucks and Uber’s Otto autonomous trucks.

Last year, Uber’s Otto completed its first shipment by self-driving truck with an autonomous beer run with Budweiser.

Source: https://electrek.co/

3D-Printed Plastic Objects Connect To The Internet Without Any Electronics

Researchers from the University of Washington (UW) have developed 3D-printed plastic objects that can connect to the internet without any electronics or batteries. The researchers found a way to 3D-print plastic objects that can absorb or reflect ambient WiFi signals and send data wirelessly to any WiFi receiver like a smartphone or router.

Possible use cases include an attachment for laundry detergent that can sense when soap is running low, or a water sensor that notifies your smartphone when there is a leak.

As the UW explains in its news release, the researchers “replaced some functions normally performed by electrical components with mechanical motion activated by springs, gears, switches and other parts that can be 3-D printed — borrowing from principles that allow battery-free watches to keep time.” The scientists found that those mechanical motions can trigger gears and springs that connect to an antenna, all within the object.
The team opens new approach: “Can objects made of plastic materials be connected to smartphones and other Wi-Fi devices, without the need for batteries or electronics? A positive answer would enable a rich ecosystem of ‘talking objects3D printed with commodity plastic filaments that have the ability to sense and interact with their surroundings. Imagine plastic sliders or knobs that can enable rich physical interaction by dynamically sending information to a nearby Wi-Fi receiver to control music volume and lights in a room. This can also transform inventory management where for instance a plastic detergent bottle can self-monitor usage and re-order supplies via a nearby Wi-Fi device.
Such a capability democratizes the vision of ubiquitous connectivity by enabling designers to download and use our computational modules, without requiring the engineering expertise to integrate radio chips and other electronics in their physical creations. Further, as the commoditization of 3D printers continues, such a communication capability opens up the potential for individuals to print highly customized wireless sensors, widgets and objects that are tailored to their individual needs and connected to the Internet ecosystem
.”

Source: http://printedwifi.cs.washington.edu/
https://www.geekwire.com/

How To Remove Air Pollution Inside Cars

You might think sitting in your car with your windows closed keeps you safe from air pollution. The makers of a new pollution-busting filter say you’d be wrong.

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When you’re in your car you’re directly in the lanes of traffic and you’re actually taking air into the car. That’s coming from the exhaust of the cars in front of you. This means that there are greatly elevated levels of air pollution inside of a vehicle. This is both for nitrogen dioxide and for particulate matter“,  says Matthew Johnson,  Professor of Chemistry at the University of Copenhagen (Denmark).

Toxic air pollution passes through air inlets inside cars. Emissions from diesel vehicles are worst. The team from University of Copenhagen and start-up Airlabs has created Airbubbl, which contains two filters.
We have a chemical filter that’s removing nitrogen dioxide and ozone and odour from the air stream. We also have a high performance particle filter that’s removing soot and road dust and brake dust and these other components. We combine that inside this case. This plugs into the cigarette lighter. We have some quiet fans at the two ends of the device and we’ve used computational fluid dynamics in order to direct the airflow towards the passengers,” explains Johnson.
Independent tests in London saw nitrogen dioxide concentrations inside cars fall by 95 percent in 10 minutes. The Airbubbl is lightweight and easily attachable. A Kickstarter campaign has been launched to market the device.

Source: https://www.reuters.com/

Crowdfunding: https://www.kickstarter.com/

Swiss Army Knife NanoVaccine To Fight Tumors

Scientists are using their increasing knowledge of the complex interaction between cancer and the immune system to engineer increasingly potent anti-cancer vaccines.
Now researchers at the National Institute ofBiomedical Imaging and Bioengineering (NIBIB) have developed a synergistic nanovaccine packing DNA and RNA sequences that modulate the immune response, along with anti-tumor antigens, into one smallnanoparticle. The nanovaccine produced an immune response that specifically killed tumor tissue, while simultaneously inhibiting tumor-induced immune suppression. Together this blocked lung tumor growth in a mouse model of metastatic colon cancer.

Large particles (left) containing the DNA and RNA components are coated with electronically charged molecules that shrink the particle. The tumor-specific neoantigen is then complexed with the surface to complete construction of the nanovaccine.
Upper left: electron micrograph of large particle

 

The molecular dance between cancer and the immune system is a complex one and scientists continue to identify the specific molecular pathways that rev up or tamp down the immune system. Biomedical engineers are using this knowledge to create nanoparticles that can carry different molecular agents that target these pathways. The goal is to simultaneously stimulate the immune system to specifically attack the tumor while also inhibiting the suppression of the immune system, which often occurs in cancer patients. The aim is to press on the gas pedal of the immune system while also releasing the emergency brake.

A key hurdle is to design a system to reproducibly and efficiently create a nanoparticle loaded with multiple agents that synergize to mount an enhanced immune attack on the tumor. Engineers at the NIBIB report the development and testing of such a nanovaccine in the journal Nature Communications.

Source: https://www.nibib.nih.gov/

How To Trap DNA molecules With Your Smartphone

Researchers from the University of Minnesota College of Science and Engineering have found yet another remarkable use for the wonder material graphenetiny electronictweezers” that can grab biomolecules floating in water with incredible efficiency. This capability could lead to a revolutionary handheld disease diagnostic system that could be run on a smart phoneGraphene, a material made of a single layer of carbon atoms, was discovered more than a decade ago and has enthralled researchers with its range of amazing properties that have found uses in many new applications from microelectronics to solar cells. The graphene tweezers developed at the University of Minnesota are vastly more effective at trapping particles compared to other techniques used in the past due to the fact that graphene is a single atom thick, less than 1 billionth of a meter.

The physical principle of tweezing or trapping nanometer-scale objects, known as dielectrophoresis, has been known for a long time and is typically practiced by using a pair of metal electrodes. From the viewpoint of grabbing molecules, however, metal electrodes are very blunt. They simply lack the “sharpness” to pick up and control nanometer-scale objects.

Graphene is the thinnest material ever discovered, and it is this property that allows us to make these tweezers so efficient. No other material can come close,” said research team leader Sang-Hyun Oh, a Professor at the University of Minnesota. “To build efficient electronic tweezers to grab biomolecules, basically we need to create miniaturized lightning rods and concentrate huge amount of electrical flux on the sharp tip. The edges of graphene are the sharpest lightning rods.

The team also showed that the graphene tweezers could be used for a wide range of physical and biological applications by trapping semiconductor nanocrystals, nanodiamond particles, and even DNA molecules. Normally this type of trapping would require high voltages, restricting it to a laboratory environment, but graphene tweezers can trap small DNA molecules at around 1 Volt, meaning that this could work on portable devices such as mobile phones.

The research study has been published  in Nature Communications.

Source: https://cse.umn.edu/

Copycat Robot

Introducing T-HR3, third generation humanoid robot designed to explore how clever joints can improve brilliant balance and real remote controlToyota says its 29 joints allow it to copy the most complex of moves – safely bringing friendly, helpful robots one step closer.


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Humanoid robots are very popular among Japanese people…creating one like this has always been our dream and that’s why we pursued it,” says Akifumi Tamaoki, manager of Partner robot division at Toyota.

The robot is controlled by a remote operator sitting in an exoskeletonmirroring its master’s moves, a headset giving the operator a realtime robot point of view.

We’re primarily focused on making this robot a very family-oriented one, so that it can help people including services such as carer” explains Tamaoki.
Toyota said T-HR3 could help around the homes or medical facilities in Japan or construction sites, a humanoid helping hand – designed for a population ageing faster than anywhere else on earth.

Source: http://toyota.com/

Nanotechnology Boosts CyberSecurity Against Hackers

The next generation of electronic hardware security may be at hand as researchers at New York University Tandon School of Engineering  (NYU Tandon) introduce a new class of unclonable cybersecurity security primitives made of a low-cost nanomaterial with the highest possible level of structural randomness. Randomness is highly desirable for constructing the security primitives that encrypt and thereby secure computer hardware and data physically, rather than by programming.

In a paper published in the journal ACS Nano, Assistant Professor of Electrical and Computer Engineering Davood Shahrjerdi and his team at NYU Tandon offer the first proof of complete spatial randomness in atomically thin molybdenum disulfide (MoS2). The researchers grew the nanomaterial in layers, each roughly one million times thinner than a human hair. By varying the thickness of each layer, Shahrjerdi explained, they tuned the size and type of energy band structure, which in turn affects the properties of the material.

(a) At monolayer thickness, this material has the optical properties of a semiconductor that emits light. At multilayer, the properties change and the material doesn’t emit light. (b) Varying the thickness of each layer results in a thin film speckled with randomly occurring regions that alternately emit or block light. (c) Upon exposure to light, this pattern can be translated into a one-of-a-kind authentication key that could secure hardware components at minimal cost.

This property is unique to this material,” underscores Shahrjerdi. By tuning the material growth process, the resulting thin film is speckled with randomly occurring regions that alternately emit or do not emit light. When exposed to light, this pattern translates into a one-of-a-kind authentication key that could secure hardware components at minimal cost.

Source: http://engineering.nyu.edu/

Glass Blocks Generate Electricity Using Solar Energy

Buildings consume more than forty percent of global electricity and reportedly cause at least a third of carbon emissions. Scientists want to cut this drastically – and create a net-zero energy future for new buildings. Build Solar want to help. The firm has created a glass brick containing small solar cells.

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On top of this we have placed in some intelligent optics which are able to focus the incoming sunlight onto these solar cells almost throughout the day. When we do that we are able to generate a higher amount of electrical output from each solar cell that we are using,” says Dr Hasan Baig, founder of Build Solar.
As well as converting the sun’s power to electricity, the bricks have other abilities.
The product is aligned to provide three different things, including electricity, daylighting, and thermal insulation which is generally required by any kind of construction product. More importantly it is aesthetic in its look, so it fits in very well within the building architecture,” adds Dr Baig.
Using Building Integrated Photovoltaics, the technology would be used in addition to existing solar roof panels. The University of Exeter spin-off is fine-tuning the design, which works in many colours. The company says the product could be market ready by the end of next year.

Source: https://www.buildsolar.co.uk/

Artificial Intelligence Chip Analyzes Molecular-level Data In Real Time

Nano Global, an Austin-based molecular data company, today announced that it is developing a chip using intellectual property (IP) from Arm, the world’s leading semiconductor IP company. The technology will help redefine how global health challenges – from superbugs to infectious diseases, and cancer are conquered.

The pioneering system-on-chip (SoC) will yield highly-secure molecular data that can be used in the recognition and analysis of health threats caused by pathogens and other living organisms. Combined with the company’s scientific technology platform, the chip leverages advances in nanotechnology, optics, artificial intelligence (AI), blockchain authentication, and edge computing to access and analyze molecular-level data in real time.

In partnership with Arm, we’re tackling the vast frontier of molecular data to unlock the unlimited potential of this universe,” said Steve Papermaster, Chairman and CEO of Nano Global. “The data our technology can acquire and process will enable us to create a safer and healthier world.”

We believe the technology Nano Global is delivering will be an important step forward in the collective pursuit of care that improves lives through the application of technology,” explained Rene Haas, executive vice president and president of IPG, Arm. “By collaborating with Nano Global, Arm is taking an active role in developing and deploying the technologies that will move us one step closer to solving complex health challenges.”

Additionally, Nano Global will be partnering with several leading institutions, including Baylor College of Medicine and National University of Singapore, on broad research initiatives in clinical, laboratory, and population health environments to accelerate data collection, analysis, and product development.
The initial development of the chip is in process with first delivery expected by 2020. The company is already adding new partners to their platform.

Source: https://nanoglobal.com/
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www.prnewswire.com

Graphene Ripples, Clean And Limitless Energy Source

Graphene is a seemingly impossible material. For years, scientists had theorized that lifting a single layer of carbon atoms from a chunk of graphite could produce the first two-dimensional material, which they called graphene. Finally, in 2004, this was accomplished by two physicists at the University of Manchester, who earned the Nobel Prize in Physics for this breakthrough. There was a problem, however: two dimensional materials violate the laws of physics. Without the support of a substrate, physics predicts they would tear apart or melt, even at a temperature of absolute zero. Physicists had to find a loophole to explain their existence.

That loophole turned out to be related to a phenomenon known as Brownian motion, small random fluctuations of the carbon atoms that make up graphene. This causes the material to ripple into the third dimension, similar to waves moving across the surface of the ocean. These movements in and out of the flat surface allow graphene to stay comfortably within the laws of physics.

Ever since Robert Brown discovered Brownian motion in 1827, scientists have wondered whether they could harvest this motion as a source of energy. The research of Paul Thibado, professor of physics at the University of Arkansas, provides strong evidence that the motion of graphene could indeed be used as a source of clean, limitless energy. Other researchers have theorized that temperature-induced curvature inversion in graphene could be used as an energy source, and even predicted the amount of energy they could produce. What sets Thibado’s work apart is his discovery that graphene has naturally occurring ripples that invert their curvature as the atoms vibrate in response to the ambient temperature.

This is the key to using the motion of 2D materials as a source of harvestable energy,” Thibado said. Unlike atoms in a liquid, which move in a random directions, atoms connected in a sheet of graphene move together. This means their energy can be collected using existing nanotechnology.

These results have been published in the journal Physical Review Letters.

Source: https://researchfrontiers.uark.edu

New Quantum Computer Uses 10,000 Times Less Power

Japan has unveiled its first quantum computer prototype, amid a global race to build ever-more powerful machines with faster speeds and larger brute force that are key towards realising the full potential of artificial intelligence. Japan’s machine can theoretically make complex calculations 100 times faster than even a conventional supercomputer, but use just 1 kilowatt of power – about what is required by a large microwave oven – for every 10,000 kilowatts consumed by a supercomputer. Launched recently, the creators – the National Institute of Informatics, telecom giant NTT and the University of Tokyo – said they are building a cloud system to house their “quantum neural network” technology.

In a bid to spur further innovation, this will be made available for free to the public and fellow researchers for trials at https://qnncloud.com
The creators, who aim to commercialise their system by March 2020, touted its vast potential to help ease massive urban traffic congestion, connect tens of thousands of smartphones to different base stations for optimal use in a crowded area, and even develop innovative new drugs by finding the right combination of chemical compounds.

Quantum computers differ from conventional supercomputers in that they rely on theoretical particle physics and run on subatomic particles such as electrons in sub-zero temperatures. Most quantum computers, for this reason, destabilise easily and are error-prone, thereby limiting their functions.

We will seek to further improve the prototype so that the quantum computer can tackle problems with near-infinite combinations that are difficult to solve, even by modern computers at high speed,” said Stanford University Professor Emeritus Yoshihisa Yamamoto, who is heading the project.
Japan’s prototype taps into a 1km-long optical fibre cable packed with photons, and exploits the properties of light to make super-quick calculations. Its researchers said they deemed the prototype ready for public use, after tests showed that it was capable of operating stably around the clock at room temperature.

Source: http://www.straitstimes.com/

How To Detect Fluoride In Drinking Water

A simple colour-changing test to detect fluoride in drinking water, devised by researchers at the University of Bath (UK), could in the future prevent the crippling bone disease, skeletal fluorosis, in developing countries such as India and Tanzania. Whilst low amounts of fluoride are beneficial for healthy teeth, high levels of fluoride can weaken bones, leading to skeletal fluorosis. This disease causes crippling deformities of the spine and joints, especially in children whose skeletons are still forming.

When water passes over certain minerals, it can dissolve fluoride, which results in elevated levels of fluoride in drinking water sources in parts of East Africa, India, China and North America. Levels of fluoride in drinking water are routinely monitored and controlled at treatment works in developed countries. However in areas of the world where there is no piped water system or treatment works, people rely on drawing untreated water from wells, which can often be contaminated with higher than recommended levels of fluoride. The amounts of fluoride in the groundwater can vary due to weather events, with levels fluctuating hugely when there is a lot of rain.

A research team at the University of Bath’s Centre for Sustainable Chemical Technologies, and the Water Innovation and Research Centre (WIRC), led by Simon Lewis, has developed a simple colour-changing test that detects high levels of fluoride quickly and selectively. Whilst the test is at the proof of concept stage, the team aims to develop it into a disposable test strip that is low cost and easy to use by anyone.

The test changes from purple to blue when the levels of fluoride in the water are too high (click to get video)

Lewis explains: “Whilst a small amount of fluoride is good for your teeth and prevents tooth decay, high levels are toxic and can cause crippling deformities that are irreversible. “Most water quality monitoring systems need a lab and power supply and a trained operator to work them. What we’ve developed is a molecule that simply changes colour in a few minutes which can tell you whether the level of fluoride is too high. “This technology is in the very early stages, but we’d like to develop this technology into test strips, similar to litmus paper, that allow people without any scientific training to perform a test that is low cost, rapid and robust. “We anticipate that in the future it could make a real difference to people’s lives.”

I am very enthusiastic about the newly developed indicator molecules and am convinced that they can be incorporated into an easy to use technology that is able to provide instant information on the safety of drinking water with regards to fluoride,” comments co-investigator Dr Jannis Wenk, of the Department of Chemical Engineering and Water Innovation and Research Centre (WIRC) at Bath.

Source: http://www.bath.ac.uk/

Printed 3D Nanostructures Against Counterfeiting

Security features are to protect bank notes, documents, and branded products against counterfeiting. Losses caused by product forgery and counterfeiting may be enormous. According to the German Engineering Association, the damage caused in 2016 in its branch alone amounted to EUR 7.3 billion. In the Advanced Materials Technologies journal, researchers of Karlsruhe Institute of Technology (KIT) and the ZEISS company now propose to use printed 3D microstructures instead of 2D structures, such as holograms, to improve counterfeit protection.

Today, optical security features, such as holograms, are frequently based on two-dimensional microstructures,” says Professor Martin Wegener, expert for 3D printing of microstructures at the Institute of Nanotechnology of KIT. “By using 3D-printed fluorescent microstructures, counterfeit protection can be increased.” The new security features have a side length of about 100 µm and are barely visible with the eye or a conventional microscope. For their production and application, Wegener and his team have developed an innovative method that covers all processes from microstructure fabrication to the readout of information.

The microstructures consist of a 3D cross-grid scaffold and dots that fluoresce in different colors and can be arranged variably in three dimensions within this grid. To produce and print such microstructures, the experts use a rapid and precise laser lithography device developed and commercialized by the Nanoscribe company, a spinoff of KIT. It enables highly precise manufacture of voluminous structures of a few millimeters edge length or of microstructured surfaces of several cm² in dimension. The special 3D printer produces the structures layer by layer from non-fluorescent and two fluorescent photoresists. A laser beam very precisely passes certain points of the liquid photoresist. The material is exposed and hardened at the focus point of the laser beam. The resulting filigree structure is then embedded in a transparent polymer in order to protect it against damage.

Source: http://www.kit.edu/

How To Use Computers Heat To Generate Electricity

Electronic devices such as computers generate heat that mostly goes to waste. Physicists at Bielefeld University (Germany) have found a way to use this energy: They apply the heat to generate magnetic signals known as ‘spin currents’. In future, these signals could replace some of the electrical current in electronic components. In a new study, the physicists tested which materials can generate this spin current most effectively from heat. The research was carried out in cooperation with colleagues from the University of Greifswald, Gießen University, and the Leibniz Institute for Solid State and Materials Research in Dresden.

The Bielefeld physicists are working on the basic principles for making data processing more effective and energy-efficient in the young field of ‘spin caloritronics’. They are members of the ‘Thin Films & Physics of Nanostructures’ research group headed by Professor Dr. Günter Reiss. Their new study determines the strength of the spin current for various combinations of thin films.

A spin current is produced by differences in temperature between two ends of an electronic component. These components are extremely small and only one millionth of a millimetre thick. Because they are composed of magnetic materials such as iron, cobalt, or nickel, they are called magnetic nanostructures.

The physicists take two such nanofilms and place a layer of metal oxide between them that is only a few atoms thick. They heat up one of the external films – for example, with a hot nanowire or a focused laser. Electrons with a specific spin orientation then pass through the metal oxide. This produces the spin current. A spin can be conceived as electrons spinning on their own axes – either clockwise or anti-clockwise.

Their findings have been  published  in the research journal ‘Nature Communications’.

Source: https://ekvv.uni-bielefeld.de/

Polymeric Materials Outperform Natural Antibodies

Experts from the Biotechnology Group led by Professor Sergey Piletsky at the University of Leicester (UK) in collaboration with the spin-off company MIP Diagnostics Ltd, have announced the development of polymeric materials with molecular recognition capabilities which hold the potential to outperform natural antibodies in various diagnostic applications.

chemical background

 In a newly released article ‘A comparison of the performance of molecularly imprinted polymer nanoparticles for small molecule targets and antibodies in the ELISA format’ the researchers successfully demonstrated that polymer nanoparticles produced by the molecular imprinting technique (MIP nanoparticles) can bind to the target molecule with the same or higher affinity and specificity than widely used commercially available antibodies and against challenging targets.

Additionally, their ease of manufacture, short lead time, high affinity and the lack of requirement for cold chain logistics make them an attractive alternative to traditional antibodies for use in immunoassays.

Professor Piletsky, from our Department of Chemistry, explained: “It is now well over twenty years since the first demonstration that molecularly imprinted polymers can be used as the recognition material in assays for clinically significant drugs“. 

Source: https://www2.le.ac.uk/

Tesla Electric Truck Travels 500 Miles (805 km) On A Single Charge

The main course was expected: a pair of sleek silver Tesla semi-trucks that get 500 miles per charge, go from zero to 60 mph in five seconds and — if the hype is to be believed — promise to single-handedly transform the commercial trucking industry. But dessert was a surprise: A bright red prototype of the newest Tesla Roadster, a revamped version of the company’s debut vehicle that can travel from Los Angeles to San Francisco and back on a single charge and go from zero to 60 mph in under two seconds. If true, that would make the $200,000 sports car the fastest production car ever made.

On Thursday night, Tesla chief executive Elon Musk delivered both dishes to a packed crowd at the company’s design studio in Hawthorne, Calif.

What does it feel like to drive this truck?” Musk asked the audience, shortly after his latest creations rolled onto the stage. “It’s amazing! It’s smooth, just like driving a Tesla.” “It’s unlike any truck that you’ve ever driven,” he added, noting that Tesla’s big rig puts the driver at the center of the vehicle like a race car, but surrounded with touchscreen displays like those found in the Model 3. “I can drive this thing and I have no idea how to drive a semi.”

Range anxiety has always been a key concern for anyone who is weighing the purchase of an electric vehicle. Musk sought to reassure potential buyers that the company’s big rigs can match — and surpass — the performance of a diesel engine, which he referred to as “economic suicide.” Musk did not reveal the truck’s exact price, but argued that a diesel truck would be 20 cents more expensive per mile than Tesla’s electric counterpart, which will be available for purchase in 2019.

Source: https://www.washingtonpost.com/

Breathing in Delhi air equivalent to smoking 44 cigarettes a day

It was early on the morning when residents in the Indian capital of Delhi first began to notice the thick white haze that had descended across the city. Initially viewed as a mild irritant, by mid-week its debilitating effects were evident to all, as the city struggled to adapt to the new eerie, martian-like conditions brought about by the pollution.

The World Health Organization considers anything above 25 to be unsafe. That measure is based on the concentration of fine particulate matter, or PM2.5, per cubic meter. The microscopic particles, which are smaller than 2.5 micrometers in diameter, are considered particularly harmful because they are small enough to lodge deep into the lungs and pass into other organs, causing serious health risks.
With visibility severely reduced, trains have been canceled, planes delayed and cars have piled into each other, with multiple traffic accidents reported across the city. On the afternoon, city chiefs closed all public and private schools, requesting instead that the city’s tens of thousands of school-aged children remain indoors; they banned incoming trucks and halted civil construction projects; while they announced new plans to begin implementing a partial ban on private car use as of next week. But as the city woke up to a fourth straight day of heavy pollution, practical considerations were being overtaken by more serious concerns, with journalists and doctors warning residents of the long-term health implications.

Air quality readings in the Indian capital have reached frightening levels in recent days, at one point topping the 1,000 mark on the US embassy air quality index. Across the capital, doctors reported a surge in patients complaining of chest pain, breathlessness and burning eyes. “The number of patients have increased obviously,” said Deepak Rosha, a pulmonologist at Apollo Hospital, one of the largest private hospitals in Delhi. “I don’t think it’s ever been so bad in Delhi. I’m very angry that we’ve had to come to this.”
Breathing in air with a PM2.5 content of between 950 to 1,000 is considered roughly equivalent to smoking 44 cigarettes a day, according to the independent Berkeley Earth science research group.

Photovoltaics: Light Absorption Enhanced by Up to 200 Percent

Sunlight reflected by solar cells is lost as unused energy. The wings of the butterfly Pachliopta aristolochiae are drilled by nanostructures (nanoholes) that help absorbing light over a wide spectrum far better than smooth surfaces. Researchers of Karlsruhe Institute of Technology (KIT) in Germany, have now succeeded in transferring these nanostructures to solar cells and, thus, enhancing their light absorption rate by up to 200 percent.

 “The butterfly studied by us is very dark black. This signifies that it perfectly absorbs sunlight for optimum heat management. Even more fascinating than its appearance are the mechanisms that help reaching the high absorption. The optimization potential when transferring these structures to photovoltaics (PV) systems was found to be much higher than expected,” says Dr. Hendrik Hölscher of KIT’s Institute of Microstructure Technology (IMT).

 

The scientists of the team of Hendrik Hölscher and Radwanul H. Siddique (formerly KIT, now Caltech) reproduced the butterfly’s nanostructures in the silicon absorbing layer of a thin-film solar cell. Subsequent analysis of light absorption yielded promising results: Compared to a smooth surface, the absorption rate of perpendicular incident light increases by 97% and rises continuously until it reaches 207% at an angle of incidence of 50 degrees. “This is particularly interesting under European conditions. Frequently, we have diffuse light that hardly falls on solar cells at a vertical angle,” Hendrik Hölscher says. However, this does not automatically imply that efficiency of the complete PV system is enhanced by the same factor, says Guillaume Gomard of IMT. “Also other components play a role. Hence, the 200 percent are to be considered a theoretical limit for efficiency enhancement.

The scientists have reported their results in the journal Science Advances. (DOI: 10.1126/sciadv.1700232.)

Source: http://www.kit.edu/

How To Correct Genes That Cause High Cholesterol

U.S. researchers have used nanotechnology plus the powerful CRISPR-Cas9 gene-editing tool to turn off a key cholesterol-related gene in mouse liver cells, an advance that could lead to new ways to correct genes that cause high cholesterol and other liver diseasesNanotechnology is the design and manipulation of materials thousands of times smaller than the width of a human hair.

We’ve shown you can make a nanoparticle that can be used to permanently and specifically edit the DNA in the liver of an adult animal,” said study author Daniel Anderson, an associate professor in chemical engineering at the Massachusetts Institute of Technology.

The study, published  in Nature Biotechnology, holds promise for permanently editing genes such as PCSK9, a cholesterol-regulating gene that is already the target of two drugs made by the biotechnology companies Regeneron Pharmaceuticals and Amgen.

In the study, the scientists were trying to develop a safe and efficient way to deliver the components needed for CRISPR-Cas9, a type of molecular scissors that can selectively trim away defective genes and replace them with new stretches of DNA.

The system consists of a DNA-cutting enzyme called Cas9 and a stretch of RNA that guides the cutting enzyme to the correct spot in the genome. Most teams currently use viruses to deliver CRISPR into cells, an approach that is limited because the immune system can develop antibodies to viruses.

To overcome this, the team chemically modified the CRISPR components to protect them from enzymes in the body that would normally break them down. They then inserted this material into nano-scale fat particles and injected them into mice, where they made their way to liver cells.

In tests targeting the PCSK9 gene, the system proved highly effective, . The PCSK9 protein made by this gene was undetectable in the treated mice, eliminating the gene in more than 80 percent of liver cells, which also experienced a 35 percent drop in total cholesterol, the researchers reported.

High levels of cholesterol can clog arteries, causing reduced blood flow that can lead to a heart attack or stroke.

Source: http://news.mit.edu/

AI, “worst event in the history of our civilisation” says Stephen Hawking

Stephen Hawking has sent a stark warning out to the world, stating that the invention of artificial intelligence (AI) could be the “worst event in the history of our civilisation”. Speaking at the Web Summit technology conference in Lisbon, Portugal, the theoretical physicist reiterated his warning against the rise of powerful, conscious machines.
While Prof Hawking admitted that AI could be used for good, he also stated that humans need to find a way to control it so that it does not become more powerful than us as “computers can, in theory, emulate human intelligence, and exceed it.” Looking at the positives, the 75-year old said AI could help undo some of the damage that humans have inflicted on the natural world, help beat disease and “transform” every aspect of society. But, there are negatives that come with it.
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Success in creating effective AI, could be the biggest event in the history of our civilisation. Or the worst. We just don’t know. “So we cannot know if we will be infinitely helped by AI, or ignored by it and side-lined, or conceivably destroyed by it. “Unless we learn how to prepare for, and avoid, the potential risks, AI could be the worst event in the history of our civilisation. It brings dangers, like powerful autonomous weapons, or new ways for the few to oppress the many. It could bring great disruption to our economy,” explains the University of Cambridge alumni.

Prof Hawking added that to make sure AI is in line with our goals, creators need to “employ best practice and effective management.” But he still has hope: “I am an optimist and I believe that we can create AI for the good of the world. “That it can work in harmony with us. We simply need to be aware of the dangers, identify them, employ the best possible practice and management, and prepare for its consequences well in advance.”

Just last week, Prof Hawking warned that AI will replace us as the dominant being on the planet.

Source: http://www.express.co.uk/

New Genetic And Stem-Cell Technology To Grow Sheets Of Skin

Somewhere in Germany’s Ruhr valley, a nine-year-old boy is doing what children do: playing football, joking around with friends and going to school. Two years ago, he was confined to a hospital bed, dying of a rare and cruel genetic skin disease. The boy had junctional epidermolysis bullosa, or JEB. He, like other people with the disease, carried a mutation in a gene that controls the integrity of the skin. Doctors could only try to ease his suffering as some 80% of his skin simply fell away.

A team of Italian researchers came to his aid by combining stem-cell techniques with gene therapy. As a young scientist at Harvard Medical School in Boston, Massachusetts, in the 1980s, Michele De Luca — the lead author of the new study — watched pioneers in skin regeneration learn to grow small sheets of skin from cells taken from burns patients, and to use them in grafts. He extended the work in Italy, applying new genetic and stem-cell technologies. He developed ways to generate stem cells from human skin, replace disease-causing genes in them and grow sheets of healthy skin on scaffolds in the lab.

He chose JEB for his first clinical trial, which he registered with the Italian Medicines Agency in 2002. Four years later, he reported his first success, in which he created healthy skin patches from biopsies to replace small areas of sloughed-off skin on the legs of a patient with a form of JEB (F. Mavilio et al. Nature Med. 12, 1397–1402; 2006). New European Commission regulations introduced in 2007 required him to pause the project while he created facilities adhering to ‘good manufacturing practices’ (GMPs) and a spin-off company to meet the demands for strengthened oversight of cell-based therapies.

Having a company refocused his team’s attention on a different type of stem-cell therapy, one likely to yield a product for the market faster. Holoclar, a treatment that replaces the eye’s cornea in a form of blindness, became the world’s first commercial stem-cell therapy in 2015.

A few months later, at the University of Modena, De Luca got a call out of the blue from doctors in Germany who were trying to treat the little boy. Because the therapy had been in a clinical trial, albeit one on hold at the time, and because De Luca could provide GMP services, German regulatory authorities quickly approved the one-off compassionate use of the JEB therapy. Surgeons in Germany sent a skin biopsy to Modena, and two major skin transplants followed. Six months after the initial biopsy, the boy returned to school. During the many months since, he has not had so much as a blister, and loves to show off his ‘new skin’. By their nature, highly personalized treatments using gene therapies and products derived from an individual’s stem cells are likely to be applicable to only a subset of patients.

Scientists and clinicians have presented the details of the recovery in Nature (T. Hirsch et al.Nature http://dx.doi.org/10.1038/nature24487; 2017). This major clinical development was based on decades of basic research. The clinical data gathered during 21 months of follow-up after the boy’s treatment have also led to major insights into human skin biology, as discussed in an accompanying News & Views (M. Aragona and C. Blanpain Naturehttp://dx.doi.org/10.1038/nature24753; 2017). For example, normal regeneration of the epidermis is directed by only a few stem-cell clones that can self-renew.

Source: http://www.nature.com/

Sophia The Robot Says: ‘I have feelings too’

Until recently, the most famous thing that Sophia the robot had ever done was beat Jimmy Fallon a little too easily in a nationally televised game of rock-paper-scissors.

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But now, the advanced artificial intelligence robot — which looks like Audrey Hepburn, mimics human expressions and may be the grandmother of robots that solve the world’s most complex problems — has a new feather in her cap:

Citizenship.

The kingdom of Saudi Arabia officially granted citizenship to the humanoid robot last week during a program at the Future Investment Initiative, a summit that links deep-pocketed Saudis with inventors hoping to shape the future.

Sophia’s recognition made international headlines — and sparked an outcry against a country with a shoddy human rights record that has been accused of making women second-class citizens.

Source: https://www.washingtonpost.com/

Smart Paper Conducts Electricity, Detects Water

In cities and large-scale manufacturing plants, a water leak in a complicated network of pipes can take tremendous time and effort to detect, as technicians must disassemble many pieces to locate the problem. The American Water Works Association indicates that nearly a quarter-million water line breaks occur each year in the U.S., costing public water utilities about $2.8 billion annually.

A University of Washington (UW) team wants to simplify the process for discovering detrimental leaks by developing “smartpaper that can sense the presence of water. The paper, laced with conductive nanomaterials, can be employed as a switch, turning on or off an LED light or an alarm system indicating the absence or presence of water.

Water sensing is very challenging to do due to the polar nature of water, and what is used now is very expensive and not practical to implement,” said lead author Anthony Dichiara, a UW assistant professor of bioresource science and engineering in the School of Environment and Forest Sciences. “That led to the reason to pursue this work.”

Along with Dichiara, a team of UW undergraduate students in the Bioresource Science and Engineering program successfully embedded nanomaterials in paper that can conduct electricity and sense the presence of water. Starting with pulp, they manipulated the wood fibers and carefully mixed in nanomaterials using a standard process for papermaking, but never before used to make sensing papers.

Discovering that the paper could detect the presence of water came by way of a fortuitous accident. Water droplets fell onto the conductive paper the team had created, causing the LED light indicating conductivity to turn off. Though at first they thought they had ruined the paper, the researchers realized they had instead created a paper that was sensitive to water.
The researchers described their discovery in a paper appearing in the Journal of Materials Chemistry A.

Source: http://www.washington.edu/

Nanocompounds Enhance Microbial Activity On Soil, Enrich Crops

We live in a world where day to day objects seems to be getting smaller and better. The advent of nanotechnology is a major contributing factor to this phenomenon. Defined as the “engineered construction of matter at the molecular level”, nanotechnology has applications and uses in a multitude of fields. From medicine, electronics, food, clothing, batteries and environment, nanotechnology seems to be pushing the limits of all these fields. Now, scientist have discovered yet another novel application of nanotechnologyfacilitating soil microbial growth.

Indian scientists from the G. B. Pant University of Agriculture and Technology, Pantnangar, Indian Veterinary Research Institute, Izatnagar, and State Council for Science & Technology, Dehradun, studied the impact of three nanocompounds on soil microbial activity and the health of plants being cultivated.

The scientists found that supplementing agricultural soils with nanocompounds like nanoclay, nanochitosan and nanozeolite led to a higher growth of microbial populations in the soil. And such an increased microbial population further led to increased levels of phosphorus, organic carbon and nitrogen in the soils, all of which are known to improve the health of crops being cultivated. Additionally, the scientists also observed increased levels of microbial enzyme activity in the soil, as well as a 50% rise in the total protein content of the soil.

Although nanoclay had the least effect on the soil’s pH, nanozeolite was found to best facilitate the growth of soil microbes. An increase in soil microbial activity along with all the other downstream benefits, caused by these nanocompounds, are all an indicator of enhanced soil health. Therefore, supplementing soils with such nanocompounds could go a long way in improving the agricultural soils, plant health and ultimately, the crop yields of the country.

Source: http://onlinelibrary.wiley.com/

‘Internet Of Water’To Manage Floodings in U.S.

The so-called ‘internet of water‘ could be part of the solution to flooding in cities across the United States. University of Michigan researchers are piloting a ‘smart stormwater system in Ann Arbor. The system combines real-time data on how much water is in the system to help regulate water flow.

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We have a network of sensors and valves and other data we can pull in, so weather forecasts and we combine all those together to figure out when is a good time to close these valves, when is a good time to open these valves?“, says Brandon Wong, researcher at the University of Michigan.

The team can control the valves remotely using smartphone apps. Eventually this could mean the water released into the wetlands around Ann Arbor being regulated autonomously.

By also having this on the internet, it doesn’t have to be me that controls it, it could be a colleague of mine, it could be the city and it could also just be autonomous“, explains Brandon Wong. With between 10 and 20 valves per square mile of the stormwater system there’s plenty of data to monitor. The team say their smart system helps ageing infrastructure cope with the increased building pressures on green areas.

So what we have done here is making use of the remaining green areas and making them more effective by putting in these valves,” adds Wong. The project won a $1.8 million grant from the National Science Foundation. If successful, it could be rolled out across the United States.

Source: http://www-personal.umich.edu/

AI-controlled Greenhouse Uses 90 Percent Less Water To Produce Salads

Californian startup  Iron Ox runs an indoor farm complete with a few hundred plants—and two robot farmers. Instead of using technology to grow genetically modified food, a former Google engineer partnered with one of his friends who had a PhD in robotics to open a technology-based farm where they plant, seed, and grow heads of lettuce.

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Iron Ox’s goal is to provide quality produce to everyone without a premium price. According to Natural Society the average head of lettuce travels 2,055 miles from farm to market, which is why fresh lettuce is often so expensive. Currently, Iron Ox only provides produce to restaurants and grocery stores in the Bay Area of California, which is why after a daily harvest, their products are hours fresh as opposed to shipped in. The company aims to open greenhouses near other major cities, guaranteeing same-day delivery from their trucks at a fraction of the price of the current supply chain.

So why the robots? Lettuce has always been a testing ground for farming innovation, from early greenhouses to closed aquaponic ecosystems. According to Iron Ox, their AI-controlled greenhouse uses 90 percent less water than traditional farms, and because of the technology, each head of lettuce receives intimate individualized attention that is not realistic with human labor. Iron Ox also says that because they grow their products indoors with no pesticides, they don’t have to worry about typical farming issues like stray animals eating their product.

Iron Ox has yet to launch a fully-functioning automated greenhouse, but hope to build their first by the end of 2017. However, Iron Ox is not the only company to experiment with robot farming. Spread, a sustainable farming organization, broke ground on their first techno-farm, which will be fully automated and operated by robots growing lettuce, in May. They have plans to expand to the Middle East next and then continue growing.

Does this mean the future of produce is automation? Not exactly. Agriculture is complex business, and not all produce can be greenhouse-grown as efficiently and effectively as lettuce. But it’s one more reason for farmers to be aware of how the robots are coming for us all.

Source: https://www.saveur.com/

Acupuncture And Nanotechnology Married To Cure Cancer

DGIST (Daegu Gyeongbuk Institute of Science and Technology) in South Korea announced that Professor Su-Il In’s research team from the department of Energy Science and Engineering has presented the possibility of cancer treatment, including colorectal cancer, using acupuncture needles that employ nanotechnology for the first time in the world.

The research team of Professor Su-Il In, through joint research with Dr. Eunjoo Kim of Companion Diagnostics & Medical Technology Research Group at DGIST and Professor Bong-Hyo Lee’s research team from the College of Oriental Medicine at Daegu Haany University, has published a study showing that the molecular biologic indicators related to anticancer effects are changed only by the treatment of acupuncture, which is widely used in oriental medicine.

In oriental medicine, treatment using acupuncture needles has been commonly practiced for thousands of years in the fields of treating musculoskeletal disorders, pain relief, and addiction relief. Recently, it has emerged as a promising treatment for brain diseases, gastrointestinal disorders, nausea, and vomiting, and studies are under way to use acupuncture to treat severe diseases.

SURFACE IMAGES OF (A) CONVENTIONAL ACUPUNCTURE NEEDLE (CN) AND, (B) THE NANOPOROUS ACUPUNCTURE NEEDLE (PN) WITH ITS (C AND D) HIGH RESOLUTION IMAGES

Not only that, Professor In’s team discovered that acupuncture needles can be used for cancer treatment which is difficult to treat in modern medicine. In this study, the researchers developed nanoporous needles with microscopic holes in the surface of the needles ranging from nanopores (nm = one billionth of a meter) to micrometers (μm = one millionth of a meter) by applying relatively simple electrochemical nanotechnology. By increasing the surface area of the needle by a factor of ten, the nanoporous needles doubled the electrophysiological signal generation function by needle stimulus.

As a result of AOM administration in rats, the rats receiving periodic acupuncture treatment with nanoporous needles were found to have a much lower incidence of abnormal vascular clusters as a precursor to colorectal cancer in the initiation stage than those in the control group.

Source: https://www.eurekalert.org/

Thin Films Power Electronics Mixed In Fabrics

Scientists at the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL) reported significant advances in the thermoelectric performance of organic semiconductors based on carbon nanotube thin films that could be integrated into fabrics to convert waste heat into electricity or serve as a small power source.

The research demonstrates significant potential for semiconducting single-walled carbon nanotubes (SWCNTs) as the primary material for efficient thermoelectric generators, rather than being used as a component in a “compositethermoelectric material containing, for example, carbon nanotubes and a polymer. The discovery is outlined in the new Energy & Environmental Science paper, Large n- and p-type thermoelectric power factors from doped semiconducting single-walled carbon nanotube thin films.

There are some inherent advantages to doing things this way,” said Jeffrey Blackburn, a senior scientist in NREL’s Chemical and Materials Science and Technology center and co-lead author of the paper with Andrew Ferguson. These advantages include the promise of solution-processed semiconductors that are lightweight and flexible and inexpensive to manufacture. Other NREL authors are Bradley MacLeod, Rachelle Ihly, Zbyslaw Owczarczyk, and Katherine Hurst. The NREL authors also teamed with collaborators from the University of Denver and partners at International Thermodyne, Inc., based in Charlotte, N.C.

Ferguson, also a senior scientist in the Chemical and Materials Science and Technology center, said the introduction of SWCNT into fabrics could serve an important function for “wearable” personal electronics. By capturing body heat and converting it into electricity, the semiconductor could power portable electronics or sensors embedded in clothing.

Source: https://www.nrel.gov/

Invisible Glass

If you have ever watched television in anything but total darkness, used a computer while sitting underneath overhead lighting or near a window, or taken a photo outside on a sunny day with your smartphone, you have experienced a major nuisance of modern display screens: glare. Most of today’s electronics devices are equipped with glass or plastic covers for protection against dust, moisture, and other environmental contaminants, but light reflection from these surfaces can make information displayed on the screens difficult to see. Now, scientists at the Center for Functional Nanomaterials (CFN) — a U.S. Department of Energy Office of Science User Facility at Brookhaven National Laboratory — have demonstrated a method for reducing the surface reflections from glass surfaces to nearly zero by etching tiny nanoscale features into them.

Whenever light encounters an abrupt change in refractive index (how much a ray of light bends as it crosses from one material to another, such as between air and glass), a portion of the light is reflected. The nanoscale features have the effect of making the refractive index change gradually from that of air to that of glass, thereby avoiding reflections. The ultra-transparent nanotextured glass is antireflective over a broad wavelength range (the entire visible and near-infrared spectrum) and across a wide range of viewing angles. Reflections are reduced so much that the glass essentially becomes invisible.

This “invisible glass” could do more than improve the user experience for consumer electronic displays. It could enhance the energy-conversion efficiency of solar cells by minimizing the amount of sunlight lost to refection. It could also be a promising alternative to the damage-prone antireflective coatings conventionally used in lasers that emit powerful pulses of light, such as those applied to the manufacture of medical devices and aerospace components.

We’re excited about the possibilities,” said CFN Director Charles Black, corresponding author on the paper published online on October 30 in Applied Physics Letters. “Not only is the performance of these nanostructured materials extremely high, but we’re also implementing ideas from nanoscience in a manner that we believe is conducive to large-scale manufacturing.”

Our role in the CFN is to demonstrate how nanoscience can facilitate the design of new materials with improved properties,” concluded Black. “This work is a great example of that–we’d love to find a partner to help advance these remarkable materials toward technology.”

Source: https://www.eurekalert.org/

Robots Soon Will Share Our Private And Sex Life

Sex robot inventor Sergi Santos isn’t just changing how men pleasure themselves — he’s potentially changing society as we know it. The Spanish scientist believes it’s only a matter of time before human-and-robot marriage is commonplace, and he’s even hatched a plan for how he can have a baby with his mechanical temptress SamanthaSamantha is Santos’ 100-pound sex robot that boasts eight different programs and the ability to make “realistic” orgasm sounds.

Santos said he believes that in the next couple of decades, we won’t just be seeing these dolls hidden in a man’s closet or under the bed — they’ll be walking down the aisle to say “I do” to their human lovers.

Speaking from his home laboratory in Barcelona (Spain), he said: “People might look at Samantha as a weird thing you read about.” “But before they know it, these robots will be doing their jobs, and marrying their children, their grandchildren, and their friends.” “They need to remember that just a few years ago, mobile phones were seen as a non-essential item in society, but now we can’t function without them.” And Santos claims he will soon be able to have a baby with Samantha. He explained: “I can make them have a baby. It’s not so difficult. I would love to have a child with a robot.” His plan involves using thebrain” he has created for Samantha but upgrading it so it is functioning at full capability.

Source: http://nypost.com/
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Editing Genes In Human Embryos

Two new CRISPR tools overcome the scariest parts of gene editing.The ability to edit RNA and individual DNA base pairs will make gene editing much more precise. Several years ago, scientists discovered a technique known as CRISPR/Cas9, which allowed them to edit DNA more efficiently than ever before.
Since then, CRISPR science has exploded; it’s become one of the most exciting and fast-moving areas of research, transforming everything from medicine to agriculture and energy. In 2017 alone, more than 14,000 CRISPR studies were published.

But here’s the thing: CRISPR, while a major leap forward in gene editing, can still be a blunt instrument. There have been problems with CRISPR modifying unintended gene targets and making worrisome, and permanent, edits to an organism’s genome. These changes could be passed down through generations, which has raised the stakes of CRISPR experiments — and the twin specters of “designer babies” and genetic performance enhancers — particularly when it comes to editing genes in human embryos.
So while CRISPR science is advancing quickly, scientists are still very much in the throes of tweaking and refining their toolkit. And on Wednesday, researchers at the Broad Institute of MIT and Harvard launched a coordinated blitz with two big reports that move CRISPR in that safer and more precise direction.
In a paper published in Science, researchers described an entirely new CRISPR-based gene editing tool that targets RNA, DNA’s sister, allowing for transient changes to genetic material. In Nature, scientists described how a more refined type of CRISPR gene editing can alter a single bit of DNA without cutting it — increasing the tool’s precision and efficiency.

The first paper, out Wednesday in Science, describes a new gene editing system. This one, from researchers at MIT and Harvard, focuses on tweaking human RNA instead of DNA.

Our cells contain chromosomes made up of chemical strands called DNA, which carry genetic information. Those genes have recipes for proteins that lead to a bunch of different traits. But to carry out the instructions in any one recipe, DNA needs another type of genetic material called RNA to get involved.

RNA is ephemeral: It acts like a middleman, or a messenger. For a gene to become a protein, that gene has to be transcribed into RNA in the cell, and the RNA is then read to make the protein. If the DNA is permanent — the family recipe book passed down through generations — the RNA is like your aunt’s scribbled-out recipe on a Post-It note, turning up only when it’s needed and disappearing again.

With the CRISPR/Cas9 system, researchers are focused on editing DNA. (For more on how that system works, read this Vox explainer.) But the new Science paper describes a novel gene editing tool called REPAIR that’s focused on using a different enzyme, Cas13, to edit that transient genetic material, the RNA, in cells. REPAIR can target specific RNA letters, or nucleosides, that are involved in single-base changes that regularly cause disease in humans.

This is hugely appealing for one big reason: With CRISPR/Cas9, the changes to the genome, or the cell’s recipe book, are permanent. You can’t undo them. With REPAIR, since researchers can target single bits of ephemeral RNA, the changes they make are transient, even reversible. So this system could fix genetic mutations without actually touching the genome (like throwing away your aunt’s Post-It note recipe without adding it to the family recipe book).

Source: https://www.vox.com/

How To Detect Lead In Water

Gitanjali Rao, 11-year-old girl, is “America’s Top Young Scientist” of this year, with her invention of Tethys, a device that detects lead in water.

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Tethys, the Greek goddess of fresh water, is a lead detection tool. What you do is first dip a disposable cartridge, which can easily be removed and attached to the core device in the water you wish to test. Once you do that, that’s basically the manual part. Then you just pull out an app on your phone and check your status and it looks like the water in this container is safe. So that’s just very simple, about like a 10 to 15 second process,” says Gitanjali Rao . The young girl was affected by the Flint, Michigan water catastrophe when the city started using the Flint River for water in 2014, sparking a crisis that was linked to an outbreak of Legionnaires’ disease, at least 12 deaths and dangerously high lead levels in children.

I was most affected about Flint, Michigan because of the amount of people that were getting affected by the lead in water. And I also realized that it wasn’t just in Flint, Michigan and there were over 5,000 water systems in the U.S. alone. In the beginning of my final presentation at the event, I talked about a little boy named Opemipo, he’s 10 years old and lives in Flint, Michigan. And he has 1 percent elevated lead levels in his blood. And he’s among the thousands of adults and children exposed to the harmful effects of lead in water. So it’s a pretty big deal out there today,” remembers Rao. The seventh-grader said it took her five months to make Tethys from start to finish.

My first couple of times when I was doing my experimentation and test, I did fail so many times and it was frustrating, but I knew that it was just a learning experience and I could definitely develop my device further by doing even more tests and getting advice from my mentor as well. So, never be afraid to try,” explains Rao, who  won the 2017 Discovery Education 3M Young Scientist Challenge, along with a $25,000 prize.

Source: http://www.reuters.com/

Self-regulating Nanoparticles Treat Cancer

Scientists from the University of Surrey have developed ‘intelligentnanoparticles which heat up to a temperature high enough to kill cancerous cells – but which then self-regulate and lose heat before they get hot enough to harm healthy tissue. The self-stopping nanoparticles could soon be used as part of hyperthermic-thermotherapy to treat patients with cancer, according to an exciting new study reported in NanoscaleThermotherapy has long been used as a treatment method for cancer, but it is difficult to treat patients without damaging healthy cells. However, tumour cells can be weakened or killed without affecting normal tissue if temperatures can be controlled accurately within a range of 42°C to 45°C.

Scientists from Surrey’s Advanced Technology Institute have worked with colleagues from the Dalian University of Technology in China to create nanoparticles which, when implanted and used in a thermotherapy session, can induce temperatures of up to 45°C. The Zn-Co-Cr ferrite nanoparticles produced for this study are self-regulating, meaning that they self-stop heating when they reach temperatures over 45°C. Importantly, the nanoparticles are also low in toxicity and are unlikely to cause permanent damage to the body.

This could potentially be a game changer in the way we treat people who have cancer. If we can keep cancer treatment sat at a temperature level high enough to kill the cancer, while low enough to stop harming healthy tissue, it will prevent some of the serious side effects of vital treatment. It’s a very exciting development which, once again, shows that the University of Surrey research is at the forefront of nanotechnologies – whether in the field of energy materials or, in this case, healthcare,” said Professor Ravi Silva, Head of the Advanced Technology Institute at the University of Surrey.

Dr. Wei Zhang, Associate Professor from Dalian University of Technology explains: “Magnetic induced hyperthermia is a traditional route of treating malignant tumours. However, the difficulties in temperature control has significantly restricted its usage If we can modulate the magnetic properties of the nanoparticles, the therapeutic temperature can be self-regulated, eliminating the use of clumsy temperature monitoring and controlling systems.

“By making magnetic materials with the Curie temperature falling in the range of hyperthermia temperatures, the self-regulation of therapeutics can be achieved. For the most magnetic materials, however, the Curie temperature is much higher than the human body can endure. By adjusting the components as we have, we have synthesized the nanoparticles with the Curie temperature as low as 34oC. This is a major nanomaterials breakthrough.”

Source: https://www.surrey.ac.uk/

Using Brain-Machine Interfaces, Mental Power Can Move Objects

A unique citizen science project in which volunteers will be trained to move a piece of steel machinery using the power of their mind begins on October 27. The Mental Work project uses brain-machine interfaces developed at EPFL (Ecole polytechnique fédérale de Lausanne) in Switzerland, a convergence of science, art, and design .

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At the mental work factory the public can come and we equip them with an EEG helmet which will read the mental activity, the electrical activity, that’s in their brain. These helmets are dry, so we don’t need gel for conductivity and they’re also wireless so they can walk through the mental factory and engage with four of our machines activating them with only their mental activity,  explains Michael Mitchell , who is one of the three co-founders of Mental Work.

The data that will be collected during the mental worker’s trajectory throughout our factory floor will then be made anonymous and given to the brain machine interface community to improve the interfaces for the future. “We think that we’re on the cusp of a cognitive revolution. Now a cognitive revolution is going to be a world where our brains are intimately connected to our physical world around us. With the development of these brain machine interfaces we think that we are really at the beginning of a moment in time where man is going to become the centre of all this technology. His brain activity is going to interact with the physical world around him in ways that we can hardly imagine today. “So I think it’s understandable if people are a little apprehensive about this technology because some people may think ‘oh, it can read my thoughts and then what are we going to do with those thoughts. Where’s the privacy level here?’ But in fact we’re only asking you to modulate your brain activity according to your own will. So it’s as simple as sending a command to a computer using a mouse or a keyboard. But this time we’re using asking you to use your brain. Now we want to bring this technology to the public at a early phase of its development so that we can create a dialogue about what kind of relationship we want to have with this technology in particular but also with man’s relationship to technology in general.

Source: https://actu.epfl.ch/

Ultra-fast Data Processing At Nanoscale

Advancement in nanoelectronics, which is the use of nanotechnology in electronic components, has been fueled by the ever-increasing need to shrink the size of electronic devices like nanocomputers in a bid to produce smaller, faster and smarter gadgets such as computers, memory storage devices, displays and medical diagnostic tools.

While most advanced electronic devices are powered by photonics – which involves the use of photons to transmit informationphotonic elements are usually large in size and this greatly limits their use in many advanced nanoelectronics systems. Plasmons, which are waves of electrons that move along the surface of a metal after it is struck by photons, holds great promise for disruptive technologies in nanoelectronics. They are comparable to photons in terms of speed (they also travel with the speed of light), and they are much smaller. This unique property of plasmons makes them ideal for integration with nanoelectronics. However, earlier attempts to harness plasmons as information carriers had little success.

Addressing this technological gap, a research team from the National University of Singapore (NUS) has recently invented a novel “converter” that can harness the speed and small size of plasmons for high frequency data processing and transmission in nanoelectronics.

This innovative transducer can directly convert electrical signals into plasmonic signals, and vice versa, in a single step. By bridging plasmonics and nanoscale electronics, we can potentially make chips run faster and reduce power losses. Our plasmonic-electronic transducer is about 10,000 times smaller than optical elements. We believe it can be readily integrated into existing technologies and can potentially be used in a wide range of applications in the future,” explained Associate Professor Christian Nijhuis from the Department of Chemistry at the NUS Faculty of Science, who is the leader of the research team behind this breakthrough.

This novel discovery was first reported in the journal Nature Photonics.

Source: http://news.nus.edu.sg/

3D Printed Concrete Bridge

Today world’s first 3D printed reinforced, pre-stressed concrete bridge was opened. The cycle bridge is part of a new road around the village of Gemert, in the Netherlands. It was printed at Eindhoven University of Technology. With the knowledge the researchers gained in this project, they are now able to design even larger printed concrete structures.
The bridge is the first civil infrastructure project to be realized with 3D-concrete printing. The bridge is 8 meters long (clear span 6.5 meters) and 3.5 meters wide. As it is a ‘worlds first’, the developers did not take any chances and tested the bridge by putting a load of 5 tons on it, which is a lot more than the load the bridge will actually carry.

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The bridge has to meet all regular requirements of course. It is designed to do its duty – to carry cyclists – for thirty years or more. With more cycles than people in the Netherlands, it is expected that hundreds of cyclists will ride over the printed bridge every day. It is part of a large road construction project, led by the company BAM Infra, and commissioned by the province of North-Brabant.
An important detail is that the researchers at Eindhoven University of Technology have succeeded in developing a process to incorporate steel reinforcement cable while laying a strip of concrete. The steel cable is the equivalent of the reinforcement mesh used in conventional concrete. It handles the tensile stress because concrete cannot deal with tensile stress adequately, but steel can.
One of the main advantages of printing concrete is that much less concrete is needed than in the conventional technique, in which a mold (formwork) is filled with concrete. By contrast, the printer deposits only the concrete where it is needed, which decreases the use of cement. This reduces CO2 emissions, as cement production has a very high carbon footprint.

Another benefit lies in the freedom of form: the printer can make any desired shape, whereas conventional concrete shapes tend to be unwieldy in shape due to use of formwork. Concrete printing also enables a much higher realization speed. No formwork structures have to be built and dismantled, and reinforcement mesh does not have to be put in place separately. Overall, the researchers think the realization will eventually be roughly three times faster than conventional concrete techniques.

Source: https://www.tue.nl/

Dyslexia Coud Be Definitively Cured

French scientists from the University of Rennes say they may have found a potential cause of dyslexia which could be treatable, hidden in tiny cells in the human eye. In a small study they found that most dyslexics had dominant round spots in both eyes – rather than in just one – leading to blurring and confusion. UK experts said the research was “very exciting” and highlighted the link between vision and dyslexia.

Not all dyslexics are likely to have the same problem. People with dyslexia have difficulties learning to read, spell or write despite normal intelligence. Often letters appear to move around and get in the wrong order and dyslexic people can have problems distinguishing left from right. Human beings have a dominant eye in the same way that people have a dominant left or right hand.
In the University of Rennes study, published in the journal Proceedings of the Royal Society B, scientists looked into the eyes of 30 non-dyslexics and 30 dyslexics.
They discovered differences in the shape of spots deep in the eye where red, green and blue cones – responsible for colour – are located. In non-dyslexics, they found that the blue cone-free spot in one eye was round and in the other eye it was oblong or unevenly shaped, making the round one more dominant. But in dyslexic people, both eyes had the same round-shaped spot, which meant neither eye was dominant. This would result in the brain being confused by two slightly different images from the eyes.

Researchers Guy Ropars and Albert le Floch said this lack of asymmetry “might be the biological and anatomical basis of reading and spelling disabilities“. They added: “For dyslexic students, their two eyes are equivalent and their brain has to successively rely on the two slightly different versions of a given visual scene.”

Source: http://www.bbc.com/

Gene Researchers Have Created Green Mice

These are no Frankenstein mice. Their green feet come courtesy of a fluorescent green jelly fish gene added to their own genome. This allows a team of British scientists to test out gene editing using CRISPR-Cas9 technology.

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“We take what were or would have been green embryos and we make them into non-green embryos, so it’s a really great way of demonstrating the method“, said Dr. Anthony Perry, reproductive biologist at the University of Bath.

The technique uses the ribonucleic acid molecule CRISPR together with the Cas9 protein enzyme. CRISPR guides the Cas9 protein to a defective part of a genome where it acts like molecular scissors to cut out a specific part of the DNA. This could revolutionise how we treat diseases with a genetic component, like sickle cell anaemia. The technique is being pioneered in the U.S.
We now have a technology that allows correction of a sequence that would lead to normally functioning cells. And I think you know the opportunities with this are really exciting and really profound. There are many diseases that are have known genetic causes that we now have in principle a way to cure,“explains Jennifer Doudna, Professor of cell biology at the University of Berkeley.
Last year two teams of U.S. based scientists used CRISPR-Cas9 technology in mice to correct the genetic mutation that causes sickle cell disease. Although researchers aren’t yet close to using CRISPR-Cas9 to edit human embryos for implantation into the womb – some are already warning against it.

Dr David King, Director of  Human Genetics Alert, comments: “It will immediately create this new form of what we call consumer eugenics, that’s to say eugenics driven by the free market and consumer preferences in which people choose the cosmetic characteristics and the abilities of their children and try to basically enhance their children to perform better than other people’s children.” Other potential applications of the technology could be to make food crops and livestock animal species disease-resistant. The British team say CRISPR-Cas9 presents a golden opportunity to prevent genetic disease.

Source: http://www.reuters.com/
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Lab-grown Diamonds

This shiny, sparkly diamond was made inside a laboratory – but it has the same chemical makeup as its counterpart found deep inside the earth.

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All the composition is exactly the same. It is a real diamond. What we’ve done is we’ve just taken what’s happened in nature and just put it in a lab,” said  Kelly Good, Director of Marketing of Pure Grown Diamonds.

Essentially, all diamonds are carbon. And inside a laboratory, scientists are using a method called microwave plasma chemical vapour deposition to grow the stones from a diamond seed. They do it by creating a plasma ball made of hydrogen inside a growth chamber. Methane, which is a carbon source, is added. The carbon mix rains down on the diamond seeds, layer by layer, creating a large, rough diamond that is cut and polished. The process takes about 10 to 12 weeks. Marketers tout the lab-grown diamonds as an eco-friendly, conflict-free alternative to mined diamonds. “Our consumer is millennials, anybody who is getting engaged are really buying the lab-grown diamonds. They also like the fact of the environmental aspect of it. That it’s grown in a greenhouse. There is less soil being moved. We have a less carbon footprint,” explains Kelly Good.

While similar in appearance, there are differences. David Weinstein, Executive Director of the International  Gemological Institute (New York), comments: “I have a crystal, a diamond and I’m looking at it and I see a peridot crystal, a green peridot crystal, I know right away, this wasn’t created in a machine. So the inclusions can really be very telling as to what the origins of the material is. And that’s what our gemologists look for.”
While lab-grown gems have been around for decades, but it’s only recently that the science and technology have made it possible to grow large, gem quality stones. And according to a report by Morgan Stanley, the lab-grown diamond market could grow by about 15 percent by the year 2020.

Source: http://www.reuters.com/

How To Clean Nuclear Waste

Cleaning up radioactive waste is a dangerous job for a human. That’s why researchers at the University of  Manchester are developing robots that could do the job for us. Five years ago, in 2011, a major earthquake and tsunami devastated the east coast of Japan, leading to explosions and subsequent radiation release at the Fukushima Daiichi Nuclear Power Station. The fuel in three of the reactors is believed to have melted, causing a large amount of contaminated water on site.

This is still to be dealt with today – which isn’t too surprising, given that the clean-up of Chernobyl is still underway 30 years after the infamous nuclear accident took place. After the accident at Chernobyl, where an extremely high level of radiation was released, workers had to be sent into areas to which you wouldn’t want to send a human being. For the safety of others, they entered the plant to survey its condition, extinguish fires and manually operate equipment and machinery – all in an environment that endangered their lives. The challenge in dismantling the site at Fukushima is the residual radiation level. In the surrounding areas levels have fallen significantly; in some places (still off limits to former residents) radiation levels actually aren’t very different from natural background levels in certain other parts of the world. But in the reactor itself a person would receive a lethal dose of radiation almost instantly.

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At Fukushima, many of the instrumentation systems, such as reactor-water level and reactor pressure, were lost in the incident. This made assessing the integrity of the plant extremely difficult as you couldn’t send people to go and look at it,” explains Professor Barry Lennox, who, alongside Dr Simon Watson at The University of Manchester, is working to find another way of getting access to such dangerous places: by using robots. Professor Lennox and Dr Watson are part of a team working to adapt robots to help clean up Fukushima. They’re developing an underwater remote-operated vehicle – the AVEXIS – to help identify highly radioactive nuclear fuel that is believed to be dispersed underwater in the damaged reactor. The robot is already aiding decommissioning efforts at Sellafield, where it will swim around the ponds storing legacy waste to map and monitor the conditions within them.

Source: https://www.manchester.ac.uk/

How To Charge Lithium Batteries 20 Times Faster

A touch of asphalt may be the secret to high-capacity lithium metal batteries that charge 10 to 20 times faster than commercial lithium-ion batteries, according to Rice University scientists. The Rice lab of chemist James Tour developed anodes comprising porous carbon made from asphalt that showed exceptional stability after more than 500 charge-discharge cycles. A high-current density of 20 milliamps per square centimeter demonstrated the material’s promise for use in rapid charge and discharge devices that require high-power density.

Scanning electron microscope images show an anode of asphalt, graphene nanoribbons and lithium at left and the same material without lithium at right. The material was developed at Rice University and shows promise for high-capacity lithium batteries that charge 20 times faster than commercial lithium-ion batteries

The capacity of these batteries is enormous, but what is equally remarkable is that we can bring them from zero charge to full charge in five minutes, rather than the typical two hours or more needed with other batteries,” Tour said.

The Tour lab previously used a derivative of asphalt — specifically, untreated gilsonite, the same type used for the battery — to capture greenhouse gases from natural gas. This time, the researchers mixed asphalt with conductive graphene nanoribbons and coated the composite with lithium metal through electrochemical deposition. The lab combined the anode with a sulfurized-carbon cathode to make full batteries for testing. The batteries showed a high-power density of 1,322 watts per kilogram and high-energy density of 943 watt-hours per kilogram.

Testing revealed another significant benefit: The carbon mitigated the formation of lithium dendrites. These mossy deposits invade a battery’s electrolyte. If they extend far enough, they short-circuit the anode and cathode and can cause the battery to fail, catch fire or explode. But the asphalt-derived carbon prevents any dendrite formation.

The finding is reported in the American Chemical Society journal ACS Nano.

Source: http://news.rice.edu/

How To Track Blood Flow In Tiny Vessels

Scientists have designed gold nanoparticles, no bigger than 100 nanometres, which can be coated and used to track blood flow in the smallest blood vessels in the body. By improving our understanding of blood flow in vivo the nanoprobes represent an opportunity to help in the early diagnosis of diseaseLight microscopy is a rapidly evolving field for understanding in vivo systems where high resolution is required. It is particularly crucial for cardiovascular research, where clinical studies are based on ultrasound technologies which inherently have lower resolution and provide limited information.

The ability to monitor blood flow in the sophisticated vascular tree (notably in the smallest elements of the microvasculaturecapillaries) can provide invaluable information to understand disease processes such as thrombosis and vascular inflammation. There are further applications for the improved delivery of therapeutics, such as targeting tumours.

Currently, blood flow in the microvasculature is poorly understood. Nanoscience is uniquely placed to help understand the processes happening in the micron-dimensioned vessels. Designing probes to monitor blood flow is challenging because of the environment; the high protein levels in plasma and the high red blood cell concentrations are detrimental to optical imaging. Conventional techniques rely on staining red blood cells, using organic dyes with short-lived usage due to photobleaching, as the tracking motif. The relatively large size of the red blood cells (7-8 micrometres), which are effectively the probes, limits the resolution in imaging and analysis of flow dynamics of the smallest vessels which are of a similar width. Therefore, to have more detailed resolution and information about the blood flow in the microvasculature, even smaller probes are required.

The key to these iridium-coated nanoparticles lies in both their small size, and in the characteristic luminescent properties. The iridium gives a luminescent signal in the visible spectrum, providing an optical window which can be detected in blood. It is also long-lived compared to organic fluorophores, while the tiny gold particles are shown to be ideal for tracking flow and detect clearly in tissues“, explains Professor Zoe Pikramenou, from the School of Chemistry at  the University of Birmingham.

The findings have been published in the journal Nanomedicine.

Source: https://www.birmingham.ac.uk/

Within 10 years Planes Could Move Up To 10 Times The Speed Of Sound

An average flight from Miami to Seattle takes about six hours and 40 minutes, but imagine being able to reduce that time to 50 minutes or less. A recent study by NASA and Binghamton University researchers could lead to a drastic decrease in flight times. The study, funded in part by the U.S. Air Force, is one of the first steps toward the creation of planes able to move at hypersonic speeds, five to 10 times the speed of soundBinghamton University Associate Professor of Mechanical Engineering Changhong Ke explained that there are currently quite a few obstacles when it comes to building these super planes. The first of which is finding a material that can hold up to hypersonic travel.

Our study used what are called boron nitride nanotubes (BNNTs). NASA currently owns one of the few facilities in the world able to produce quality BNNTs.” Typically, carbon nanotubes have been used in planes for their strength — they’re stronger than steel — and their ability to conduct heat. However, BNNTs are the wave of the future when it comes to air travel. “While carbon nanotubes can stay stable at temperatures up to 400 degrees Celsius, our study found that BNNTs can withstand up to 900 degrees Celsius,” said Ke. BNNTs are also able to handle high amounts of stress and are extremely lightweight.

Withstanding high temperatures is an important requirement for any material meant to build the world’s next super planes, however, Ke clarified that the material has to be able to maintain both structural and mechanical properties in an oxygen environment. “We weren’t testing this material in a vacuum like what you would experience in space. Materials can withstand much higher temperatures in space. We wanted to see if BNNTs could hold up in the type of environment an average fighter jet or commercial plane would experience.”

While the study has brought new light to the strength and stability of BNNTs, their use on planes may not be a reality for another five to 10 years. “Right now, BNNTs cost about $1,000 per gram. It would be impractical to use a product that expensive,” added Ke. But, that does not mean it will never happen. Carbon nanotubes were about the same price 20 years ago. As more studies indicated the usefulness of carbon nanotubes, the production rates increased and prices went down to the current rate, between $10 and $20 per gram. Ke sees the same fate coming down the line for BNNTs.

Source: https://www.binghamton.edu/

How To Extract Hydrogen Fuel from Seawater

It’s possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF researcher Yang Yang from the University of Central Florida (UCF)  has come up with a new hybrid nanomaterial that harnesses solar energy and uses it to generate hydrogen from seawater more cheaply and efficiently than current materials. The breakthrough could someday lead to a new source of the clean-burning fuel, ease demand for fossil fuels and boost the economy of Florida, where sunshine and seawater are abundant. Yang, an assistant professor with joint appointments in the University of Central Florida’s NanoScience Technology Center and the Department of Materials Science and Engineering, has been working on solar hydrogen splitting for nearly 10 years.

It’s done using a photocatalyst – a material that spurs a chemical reaction using energy from light. When he began his research, Yang focused on using solar energy to extract hydrogen from purified water. It’s a much more difficulty task with seawater; the photocatalysts needed aren’t durable enough to handle its biomass and corrosive salt.

We’ve opened a new window to splitting real water, not just purified water in a lab,” Yang said. “This really works well in seawater.”

As reported in the journal Energy & Environmental Science, Yang and his research team have developed a new catalyst that’s able to not only harvest a much broader spectrum of light than other materials, but also stand up to the harsh conditions found in seawater.

 

Source: https://today.ucf.edu/

How To Fix Duchenne Muscular Dystrophy

Scientists at the University of California, Berkeley, have engineered a new way to deliver CRISPR-Cas9 gene-editing technology inside cells and have demonstrated in mice that the technology can repair the mutation that causes Duchenne muscular dystrophy, a severe muscle-wasting disease. A new study shows that a single injection of CRISPR-Gold, as the new delivery system is called, into mice with Duchenne muscular dystrophy led to an 18-times-higher correction rate and a two-fold increase in a strength and agility test compared to control groups.

Since 2012, when study co-author Jennifer Doudna, a professor of molecular and cell biology and of chemistry at UC Berkeley, and colleague Emmanuelle Charpentier, of the Max Planck Institute for Infection Biology, repurposed the Cas9 protein to create a cheap, precise and easy-to-use gene editor, researchers have hoped that therapies based on CRISPR-Cas9 would one day revolutionize the treatment of genetic diseases. Yet developing treatments for genetic diseases remains a big challenge in medicine. This is because most genetic diseases can be cured only if the disease-causing gene mutation is corrected back to the normal sequence, and this is impossible to do with conventional therapeutics.

CRISPR/Cas9, however, can correct gene mutations by cutting the mutated DNA and triggering homology-directed DNA repair. However, strategies for safely delivering the necessary components (Cas9, guide RNA that directs Cas9 to a specific gene, and donor DNA) into cells need to be developed before the potential of CRISPR-Cas9-based therapeutics can be realized. A common technique to deliver CRISPR-Cas9 into cells employs viruses, but that technique has a number of complications. CRISPR-Gold does not need viruses.

In the new study, research lead by the laboratories of Berkeley bioengineering professors Niren Murthy and Irina Conboy demonstrated that their novel approach, called CRISPR-Gold because gold nanoparticles are a key component, can deliver Cas9 – the protein that binds and cuts DNA – along with guide RNA and donor DNA into the cells of a living organism to fix a gene mutation.

CRISPR-Gold is the first example of a delivery vehicle that can deliver all of the CRISPR components needed to correct gene mutations, without the use of viruses,” Murthy said.

The study was published in the journal Nature Biomedical Engineering.

Source: http://news.berkeley.edu/

Paper Supercapacitor

By coating ordinary paper with layers of gold nanoparticles and other materials, researchers have fabricated flexible paper supercapacitors that exhibit the best performance of any textile-type supercapacitor to date. In particular, the paper supercapacitors address one of the biggest challenges in this area, which is to achieve a high energy density in addition to an already high power density, since both properties are essential for realizing high-performance energy-storage devices. In the future, flexible paper supercapacitors could be used in wearable electronics for biomedical, consumer, and military applications. The researchers, led by Seung Woo Lee at the Georgia Institute of Technology and Jinhan Cho at Korea University, have published a paper on the flexible paper supercapacitor electrodes in a recent issue of Nature Communications. As energy-storage devices, supercapacitors have several advantages over batteries, such as a higher power density, rapid charge/discharge rate, and longer lifetime, yet they lag behind batteries in energy density (the amount of energy that can be stored in a given amount of space). Although several methods have been attempted to improve the energy density of paper supercapacitors by coating them with various conductive materials, often these methods have the drawback of reducing the power density.

The paper electrodes based on layer-by-layer-assembled metal nanoparticles exhibit metal-like electric conductivity, paper-like mechanical properties, and a large surface area without any thermal treatment and/or mechanical pressing,” explains coauthor Yongmin Ko at Korea University. “The periodic insertion of metal nanoparticles within high-energy nanoparticle-based paper electrodes could resolve the critical tradeoff in which an increase in the loading amount of materials to enhance the energy density of supercapacitors decreases the power density.”
Tests  showed that the flexible paper supercapacitors had a maximum capacitance that is higher than any previously reported textile-based supercapacitor. In addition, the new devices exhibits an excellent capacity retention, demonstrated by a 90% capacity retention after 5,000 bending cycles.

Source: http://me.gatech.edu/

One-Two Knockout Punch To Eradicate Super Bugs

Light-activated nanoparticles, also known as quantum dots, can provide a crucial boost in effectiveness for antibiotic treatments used to combat drug-resistant superbugs such as E. coli and Salmonella, new CU Boulder research shows. Multi-drug resistant pathogens, which evolve their defenses faster than new antibiotic treatments can be developed to treat them, cost the United States an estimated $20 billion in direct healthcare costs and an additional $35 billion in lost productivity in 2013. Rather than attacking the infecting bacteria conventionally, the dots release superoxide, a chemical species that interferes with the bacteria’s metabolic and cellular processes, triggering a fight response that makes it more susceptible to the original antibiotic.

We’ve developed a one-two knockout punch,” said Prashant Nagpal, an assistant professor in CU Boulder’s Department of Chemical and Biological Engineering (CHBE) and the co-lead author of the study. “The bacteria’s natural fight reaction [to the dots] actually leaves it more vulnerable.”

We are thinking more like the bug,” explains Anushree Chatterjee, an assistant professor in CHBE and the co-lead author of the study. “This is a novel strategy that plays against the infection’s normal strength and catalyzes the antibiotic instead.” The dots reduced the effective antibiotic resistance of the clinical isolate infections by a factor of 1,000 without producing adverse side effects.

The findings have been published today in the journal Science Advances.

Source: http://www.colorado.edu/

How To Forge Graphene In 3D Shape

The wonder material graphene gets many of its handy quirks from the fact that it exists in two dimensions, as a sheet of carbon only one atom thick. But to actually make use of it in practical applications, it usually needs to be converted into a 3D form. Now, researchers have developed a new and relatively simple way to do just that, using lasers to “forge” a three-dimensional pyramid out of graphene.

This isn’t the first time graphene has been given an extra dimension. In 2015, researchers from the University of Illinois molded graphene into 3D structures by layering it onto shaped substrates, and early this year MIT scientists found that tubes of the stuff could be shaped into 3D coral-like structures 10 times stronger than steel but just five percent as dense. Rice University researchers have also recently made graphene foam and reinforced it with carbon nanotubes.

But this new technique, developed by researchers in Finland and Taiwan, might be an easier and faster method to make 3D graphene. By focusing a laser onto a fine point on a 2D graphene lattice, the graphene at that spot is irradiated and bulges outwards. A variety of three-dimensional shapes can be made by writing patterns with the laser spot, with the height of the shape controlled by adjusting the irradiation dose at each particular point.

The team illustrated that technique by deforming a sheet of graphene into a 3D pyramid, standing 60 nm high. That sounds pretty tiny, but it’s 200 times taller than the graphene sheet itself.

We call this technique optical forging, since the process resembles forging metals into 3D shapes with a hammer,” says Mika Pettersson, co-author of the study. “In our case, a laser beam is the hammer that forges graphene into 3D shapes. The beauty of the technique is that it’s fast and easy to use; it doesn’t require any additional chemicals or processing. Despite the simplicity of the technique, we were very surprised initially when we observed that the laser beam induced such substantial changes on graphene. It took a while to understand what was happening.”

The researchers initially assumed that the laser had “doped” the graphene, introducing impurities into the material, but after further examination they found that wasn’t the case.

When we first examined the irradiated graphene, we were expecting to find traces of chemical species incorporated into the graphene, but we couldn’t find any,” comments Wei Yen Woon, co-author of the study. “After some more careful inspections, we concluded that it must be purely structural defects, rather than chemical doping, that are responsible for such dramatic changes on graphene.

The scientists explain that the optically forged graphene is structurally sound, highlighting its potential for building 3D architectures out of the material for a wide range of applications. In this form, the graphene has different electronic and optical properties from its 2D counterpart.

The research was published in the journal Nano Letters.

Source: Academy of Finland

The Ultra Smart Community Of The Future

Japan’s largest electronics show CEATEC – showcasing its version of our future – in a connected world with intelligent robots And cars that know when the driver is falling asleep. This is Omron‘s “Onboard Driving Monitoring Sensor,” checking its driver isn’t distracted.

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We are developing sensors that help the car judge what state the driver is in, with regards to driving. For example, if the driver has his eyes open and set on things he should be looking at, if the driver is distracted or looking at smartphones, and these types of situations,” explains Masaki Suwa, Omron Corp. Chief Technologist.

After 18 years of consumer electronics, CEATEC is changing focus to the Internet of Things and what it calls ‘the ultra-smart community of the future‘ A future where machines take on more important roles – machines like Panasonic‘s CaloRieco – pop in your plate and know exactly what you are about to consume.

By placing freshly cooked food inside the machine, you can measure total calories and the three main nutrients: protein, fat and carbohydrate. By using this machine, you can easily manage your diet,” says Panasonic staff engineer Ryota Sato.

Even playtime will see machines more involved – like Forpheus the ping playing robot – here taking on a Olympic bronze medalist – and learning with every stroke.
Rio Olympics Table Tennis player , Jun Mizutani, Bronze Medalist, reports: “It wasn’t any different from playing with a human being. The robot kept improving and getting better as we played, and to be honest, I wanted to play with it when it had reached its maximum level, to see how good it is.”

Graphene, Not Glass, Is The Key To Better Optics

A lens just a billionth of a metre thick could transform phone cameras. Researchers at Swinburne University in Melbourne, Australia, have created ultra-thin lenses that cap an optical fibre, and can produce images with the quality and sharpness of much larger glass lenses.

Compared with current lenses, our graphene lens only needs one film to achieve the same resolution,” says Professor Baohua Jia, a research leader at Swinburne’s Centre for Micro-Photonics. “In the future, mobile phones could be much thinner, without having to sacrifice the quality of their cameras. Our lens also allows infrared light to pass through, which glass lenses don’t.”

Producing graphene can be costly and challenging, so Baohua and her colleagues used a laser to pattern layers of graphene oxide (graphene combined with oxygen). By then removing the oxygen, they produced low-cost, patterned films of graphene, a thousand times thinner than a human hair. “By patterning the graphene oxide film in this way, its optical and electrical properties can be altered, which allowed us to place them in different devices,” she says.

Warm objects give off infrared light, so mobile phones with graphene lenses could be used to scan for hotspots in the human body and help in the early identification of diseases like breast cancer. By attaching the lens to a fibre optic tip, endoscopes — instruments that are currently several millimetres wide—could be made a million times smaller. The team is also investigating graphene’s amazing properties for their potential use as supercapacitors, capable of storing very large amounts of energy, which could replace conventional batteries.

Baohua’s work on graphene lenses was published in Nature Communications.

Source: https://cosmosmagazine.com/

Ancient Ink To Prevent Cancer Metastasis

For hundreds of years, Chinese calligraphers have used a plant-based ink to create beautiful messages and art. Now, a team of researchers from Fudan University (China)  reports in ACS Omega that this ink could noninvasively and effectively treat cancer cells that spread, or metastasize, to lymph nodes. Finding a simple and effective strategy to eliminate tumor metastatic lymph nodes is highly desired in clinical tumor treatment. Herein, we reported a Chinese traditional ink (Hu-ink)-based treatment for photothermal therapy (PTT) of tumor metastatic lymph nodes. By simple dilution, stable ink dispersion was obtained, which presents excellent photothermal effect because of its high absorption in near-infrared (NIR) region.

Meanwhile, as revealed by staining and photoacoustic imaging, Hu-ink could transfer to nearby lymph nodes after directly injected into the primary tumors. Under the guidance of dual-modality mapping, the metastatic sentinel lymph nodes could be subsequently eliminated by NIR irradiation.

 

The good biocompatibility of Hu-ink has also been verified by a series of experiments. Therefore, the Hu-ink-based treatment exhibits great potential for PTT of tumor metastatic lymph nodes in future clinical practice.

Source: http://pubs.acs.org/

Flying Electric Planes Between London And Paris

EasyJet could be flying planes powered by batteries rather than petroleum to destinations including Paris and Amsterdam within a decade. The UK carrier has formed a partnership with US firm Wright Electric, which is developing a battery-propelled aircraft for flights under two hoursEasyJet said the move would enable battery-powered aircraft to travel short-haul routes such as London to Paris and Amsterdam, and Edinburgh to Bristol. Wright Electric is aiming for an aircraft range of 335 miles, which would cover the journeys of about a fifth of passengers flown by easyJet.

Carolyn McCall, easyJet’s chief executive, said the aerospace industry would follow the lead of the automotive industry in developing electric engines that would cut emissions and noise.

For the first time in my career I can envisage a future without jet fuel and we are excited to be part of it,” she said. “It is now more a matter of when, not if, a short-haul electric plane will fly.”

The company said it was the next step in making the airline less harmful for the environment, after cutting carbon emissions per passenger kilometre by 31% between 2000 and 2016. Wright Electric claims that electric planes will be 50% quieter and 10% cheaper for airlines to buy and operate, with the cost saving potentially passed on to passengers. The US firm said its goal was for every short flight to be electric within 20 years. It has already built a two-seater prototype and is working towards a fully electric plane within a decade. The next step is to scale-up the technology to a 10-seater aircraft, and eventually to build a single aisle, short haul commercial plane, with the capacity to carry at least 120 passengers.

Source: https://www.theguardian.com/

Renewable Fuel From Water

Physicists at Lancaster University (in UK) are developing methods of creating renewable fuel from water using quantum technologyRenewable hydrogen can already be produced by photoelectrolysis where solar power is used to split water molecules into oxygen and hydrogen. But, despite significant research effort over the past four decades, fundamental problems remain before this can be adopted commercially due to inefficiency and lack of cost-effectivenessDr Manus Hayne  from the Department of Physics said: “For research to progress, innovation in both materials development and device design is clearly needed.

The Lancaster study, which formed part of the PhD research of Dr Sam Harrison, and is published in Scientific Reports, provides the basis for further experimental work into the solar production of hydrogen as a renewable fuel. It demonstrates that the novel use of nanostructures could increase the maximum photovoltage generated in a photoelectrochemical cell, increasing the productivity of splitting water molecules.

To the authors’ best knowledge, this system has never been investigated either theoretically or experimentally, and there is huge scope for further work to expand upon the results presented here,” said Dr Haynes. “Fossil-fuel combustion releases carbon dioxide into the atmosphere, causing global climate change, and there is only a finite amount of them available for extraction. We clearly need to transition to a renewable and low-greenhouse-gas energy infrastructure, and renewable hydrogen is expected to play an important role.

Fossil fuels accounted for almost 90% of energy consumption in 2015, with absolute demand still increasing due to a growing global population and increasing industrialisationPhotovoltaic solar cells are currently used to convert sunlight directly into electricity but solar hydrogen has the advantage that it is easily stored, so it can be used as and when needed. Hydrogen is also very flexible, making it highly advantageous  for remote communities. It can be converted to electricity in a fuel cell, or burnt in a boiler or cooker just like natural gas. It can even be used to fuel aircraft.

Source: http://www.lancaster.ac.uk/

Nanogels For Heart Attack Patients

Heart disease and heart-related illnesses are a leading cause of death around the world, but treatment options are limited. Now, one group reports in ACS Nano that encapsulating stem cells in a nanogel could help repair damage to the heart.

Myocardial infarction, also known as a heart attack, causes damage to the muscular walls of the heart. Scientists have tried different methods to repair this damage. For example, one method involves directly implanting stem cells in the heart wall, but the cells often don’t take hold, and sometimes they trigger an immune reaction. Another treatment option being explored is injectable hydrogels, substances that are composed of water and a polymer. Naturally occurring polymers such as keratin and collagen have been used but they are expensive, and their composition can vary between batches. So Ke Cheng, Hu Zhang, Jinying Zhang and colleagues wanted to see whether placing stem cells in inexpensive hydrogels with designed tiny pores that are made in the laboratory would work.

The team encapsulated stem cells in nanogels, which are initially liquid but then turn into a soft gel when at body temperature. The nanogel didn’t adversely affect stem cell growth or function, and the encased stem cells didn’t trigger a rejection response. When these enveloped cells were injected into mouse and pig hearts, the researchers observed increased cell retention and regeneration compared to directly injecting just the stem cells. In addition, the heart walls were strengthened. Finally, the group successfully tested the encapsulated stem cells in mouse and pig models of myocardial infarction.

Source: https://www.acs.org/
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Computer Reads Body Language

Researchers at Carnegie Mellon University‘s Robotics Institute have enabled a computer to understand body poses and movements of multiple people from video in real time — including, for the first time, the pose of each individual’s hands and fingers. This new method was developed with the help of the Panoptic Studio — a two-story dome embedded with 500 video cameras — and the insights gained from experiments in that facility now make it possible to detect the pose of a group of people using a single camera and a laptop computer.

Yaser Sheikh, associate professor of robotics, said these methods for tracking 2-D human form and motion open up new ways for people and machines to interact with each other and for people to use machines to better understand the world around them. The ability to recognize hand poses, for instance, will make it possible for people to interact with computers in new and more natural ways, such as communicating with computers simply by pointing at things.

Detecting the nuances of nonverbal communication between individuals will allow robots to serve in social spaces, allowing robots to perceive what people around them are doing, what moods they are in and whether they can be interrupted. A self-driving car could get an early warning that a pedestrian is about to step into the street by monitoring body language. Enabling machines to understand human behavior also could enable new approaches to behavioral diagnosis and rehabilitation, for conditions such as autism, dyslexia and depression.

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We communicate almost as much with the movement of our bodies as we do with our voice,” Sheikh said. “But computers are more or less blind to it.”

In sports analytics, real-time pose detection will make it possible for computers to track not only the position of each player on the field of play, as is now the case, but to know what players are doing with their arms, legs and heads at each point in time. The methods can be used for live events or applied to existing videos.

To encourage more research and applications, the researchers have released their computer code for both multi-person and hand pose estimation. It is being widely used by research groups, and more than 20 commercial groups, including automotive companies, have expressed interest in licensing the technology, Sheikh said.

Sheikh and his colleagues have presented reports on their multi-person and hand pose detection methods at CVPR 2017, the Computer Vision and Pattern Recognition Conference  in Honolulu.

Source: https://www.cmu.edu/

Biomaterial To Replace Plastics And Reduce Pollution

An inexpensive biomaterial that can be used to sustainably replace plastic barrier coatings in packaging and many other applications has been developed by Penn State researchers, who predict its adoption would greatly reduce pollution. Completely compostable, the material — a polysaccharide polyelectrolyte complex — is comprised of nearly equal parts of treated cellulose pulp from wood or cotton, and chitosan, which is derived from chitin — the primary ingredient in the exoskeletons of arthropods and crustaceans. The main source of chitin is the mountains of leftover shells from lobsters, crabs and shrimp consumed by humans.

These environmentally friendly barrier coatings have numerous applications ranging from water-resistant paper, to coatings for ceiling tiles and wallboard, to food coatings to seal in freshness, according to lead researcher Jeffrey Catchmark, professor of agricultural and biological engineering, College of Agricultural Sciences.

In the research, paperboard coated with the biomaterial exhibited strong oil and water barrier properties. The coating also resisted toluene, heptane and salt solutions and exhibited improved wet and dry mechanical and water vapor barrier properties.

The material’s unexpected strong, insoluble adhesive properties are useful for packaging as well as other applications, such as better performing, fully natural wood-fiber composites for construction and even flooring,” Jeffrey Catchmark said. “And the technology has the potential to be incorporated into foods to reduce fat uptake during frying and maintain crispness. Since the coating is essentially fiber-based, it is a means of adding fiber to diets.”

Source: http://news.psu.edu/

Nano Robots Build Molecules

Scientists at The University of Manchester have created the world’s first ‘molecular robot’ that is capable of performing basic tasks including building other molecules.

The tiny robots, which are a millionth of a millimetre in size, can be programmed to move and build molecular cargo, using a tiny robotic arm.

Each individual robot is capable of manipulating a single molecule and is made up of just 150 carbon, hydrogen, oxygen and nitrogen atoms. To put that size into context, a billion billion of these robots piled on top of each other would still only be the same size as a single grain of salt. The robots operate by carrying out chemical reactions in special solutions which can then be controlled and programmed by scientists to perform the basic tasks.

In the future such robots could be used for medical purposes, advanced manufacturing processes and even building molecular factories and assembly lines.

All matter is made up of atoms and these are the basic building blocks that form molecules. Our robot is literally a molecular robot constructed of atoms just like you can build a very simple robot out of Lego bricks, explains Professor David Leigh, who led the research at University’s School of Chemistry. “The robot then responds to a series of simple commands that are programmed with chemical inputs by a scientistIt is similar to the way robots are used on a car assembly line. Those robots pick up a panel and position it so that it can be riveted in the correct way to build the bodywork of a car. So, just like the robot in the factory, our molecular version can be programmed to position and rivet components in different ways to build different products, just on a much smaller scale at a molecular level.”

The research has been published in Nature.

Source: http://www.manchester.ac.uk/

New Treatment To Kill Cancer

Raise your hand if you haven’t been touched by cancer,” says Mylisa Parette to a roomful of strangers. Parette, the research manager for Keystone Nano (KN), has occasional opportunities to present her company’s technologies to business groups and wants to emphasize the scope of the problem that still confronts society. “It’s easier to see the effects of cancer when nobody raises their hand,” she says. Despite 40 years of the War on Cancer, one in two men and one in three women will be diagnosed with the disease at some point in their lifetime. Parette and her Keystone Nano colleagues are working on a new approach to cancer treatment. The company was formed from the collaboration of two Penn State faculty members who realized that the nanoparticle research that the one was undertaking could be used to solve the drug delivery problems that the other was facing.

Mark Kester, a pharmacologist at Penn State College of Medicine in Hershey, was working with a new drug that showed real promise as a cancer therapy but that could be dangerous if injected directly into the bloodstream. Jim Adair, a materials scientist in University Park, was creating nontoxic nanoparticles that could enclose drugs that might normally be toxic or hydrophobic and were small enough to be taken up by cells.

The two combined their efforts and, licensing the resulting technology from Penn State, they joined with entrepreneur Jeff Davidson, founder of the Biotechnology Institute and the Pennsylvania Biotechnology Association, to form Keystone Nano. The new company’s first hire was Parette, whose job is to translate the lab-scale technology into something that can be ramped up to an industrial scale, and to prepare that technology for FDA approval leading to clinical trials.

Davidson, Parette, and KN’s research team work out of the Zetachron building, a long, one-story science incubator a mile from Penn State’s University Park campus. Operated by the Centre County Industrial Development Corporation, the building was originally the home of the successful Penn State spin-out company that gave it its name. A second Keystone Nano lab was recently opened in the Hershey Center for Applied Research, a biotech incubator adjacent to Penn State College of Medicine.

Our excitement is that we think our technology has shown efficacy in a whole range of animal models,” Davidson, Keystone CEO, remarks during a recent meeting in the shared conference room at Zetachron. “We understand the method of action, the active ingredient. We think it has every chance of being useful in treating disease. Our question is, how do we push this forward from where we are today to determining, one way or another, that it really does work?

Keystone Nano is pioneering two approaches to cancer therapy, both of which rely on advances in nanotechnology to infiltrate tumors and deliver a therapeutic agent. The approach nearest to clinical trials is a ceramide nanoliposome, or what Davidson calls a “nano fat ball around an active ingredient.” Kester, in whose lab the approach was developed, thinks of it as a basketball with a thick bilayer coating that contains 30 percent active ceramide and a hollow interior that can hold another cancer drug.

Source: http://news.psu.edu/

Optical Computer

Researchers at the University of Sydney (Australia) have dramatically slowed digital information carried as light waves by transferring the data into sound waves in an integrated circuit, or microchipTransferring information from the optical to acoustic domain and back again inside a chip is critical for the development of photonic integrated circuits: microchips that use light instead of electrons to manage data.

These chips are being developed for use in telecommunications, optical fibre networks and cloud computing data centers where traditional electronic devices are susceptible to electromagnetic interference, produce too much heat or use too much energy.

The information in our chip in acoustic form travels at a velocity five orders of magnitude slower than in the optical domain,” said Dr Birgit Stiller, research fellow at the University of Sydney and supervisor of the project.

It is like the difference between thunder and lightning,” she said.

This delay allows for the data to be briefly stored and managed inside the chip for processing, retrieval and further transmission as light wavesLight is an excellent carrier of information and is useful for taking data over long distances between continents through fibre-optic cables.

But this speed advantage can become a nuisance when information is being processed in computers and telecommunication systems.

Source: https://sydney.universty.au/

Skin Patches Melt Fat

Researchers have devised a medicated skin patch that can turn energy-storing white fat into energy-burning brown fat locally while raising the body’s overall metabolism. The patch could be used to burn off pockets of unwanted fat such as “love handles” and treat metabolic disorders, such as obesity and diabetes, according to researchers at Columbia University Medical Center (CUMC) and the University of North Carolina. Humans have two types of fat. White fat stores excess energy in large triglyceride droplets. Brown fat has smaller droplets and a high number of mitochondria that burn fat to produce heat. Newborns have a relative abundance of brown fat, which protects against exposure to cold temperatures. But by adulthood, most brown fat is lost.

For years, researchers have been searching for therapies that can transform an adult’s white fat into brown fat—a process named browning—which can happen naturally when the body is exposed to cold temperatures—as a treatment for obesity and diabetes.

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There are several clinically available drugs that promote browning, but all must be given as pills or injections,” said study co-leader Li Qiang, PhD, assistant professor of pathology & cell biology at Columbia. “This exposes the whole body to the drugs, which can lead to side effects such as stomach upset, weight gain, and bone fractures. Our skin patch appears to alleviate these complications by delivering most drugs directly to fat tissue.

To apply the treatment, the drugs are first encased in nanoparticles, each roughly 250 nanometers (nm) in diameter—too small to be seen by the naked eye. (In comparison, a human hair is about 100,000 nm wide.) The nanoparticles are then loaded into a centimeter-square skin patch containing dozens of microscopic needles. When applied to skin, the needles painlessly pierce the skin and gradually release the drug from nanoparticles into underlying tissue.

The findings, from experiments in mice, were published online today in ACS Nano.

Source: http://newsroom.cumc.columbia.edu/

Very Fast Magnetic Data Storage

For almost seventy years now, magnetic tapes and hard disks have been used for data storage in computers. In spite of many new technologies that have been developed in the meantime, the controlled magnetization of a data storage medium remains the first choice for archiving information because of its longevity and low price. As a means of realizing random access memories (RAMs), however, which are used as the main memory for processing data in computers, magnetic storage technologies were long considered inadequate. That is mainly due to its low writing speed and relatively high energy consumption.

In 1956, IBM introduced the first magnetic hard disc, the RAMAC. ETH researchers have now tested a novel magnetic writing technology that could soon be used in the main memories of modern computers

Pietro Gambardella, Professor at the Department of Materials of the Eidgenössische Technische Hochschule Zürich (ETHZ, Switzerland), and his colleagues, together with colleagues at the Physics Department and at the Paul Scherrer Institute (PSI), have now shown that using a novel technique, magnetic storage can still be achieved very fast and without wasting energy.

In 2011, Gambardella and his colleagues already demonstrated a technique that could do just that: An electric current passing through a specially coated semiconductor film inverted the magnetization in a tiny metal dot. This is made possible by a physical effect called spin-orbit-torque. In this effect, a current flowing in a conductor leads to an accumulation of electrons with opposite magnetic moment (spins) at the edges of the conductor. The electron spins, in turn, create a magnetic field that causes the atoms in a nearby magnetic material to change the orientation of their magnetic moments. In a new study the scientists have now investigated how this process works in detail and how fast it is.

The results were recently published in the scientific journal Nature Nanotechnology.

Source: https://www.ethz.ch/

Robots With The Sense Of Touch

A team of researchers from the University of Houston (UH) has reported a breakthrough in stretchable electronics that can serve as an artificial skin, allowing a robotic hand to sense the difference between hot and cold, while also offering advantages for a wide range of biomedical devices.

Cunjiang Yu, Bill D. Cook Assistant Professor of mechanical engineering and lead author for the paper, said the work is the first to create a semiconductor in a rubber composite format, designed to allow the electronic components to retain functionality even after the material is stretched by 50 percent. The semiconductor in rubber composite format enables stretchability without any special mechanical structure. Yu noted that traditional semiconductors are brittle and using them in otherwise stretchable materials has required a complicated system of mechanical accommodations. “That’s both more complex and less stable than the new discovery, as well as more expensive.”

Our strategy has advantages for simple fabrication, scalable manufacturing, high-density integration, large strain tolerance and low cost,” he said.

Yu and the rest of the team – co-authors include first author Hae-Jin Kim, Kyoseung Sim and Anish Thukral, all with the UH Cullen College of Engineering – created the electronic skin and used it to demonstrate that a robotic hand could sense the temperature of hot and iced water in a cup. The skin also was able to interpret computer signals sent to the hand and reproduce the signals as .

The robotic skin can translate the gesture to readable letters that a person like me can understand and read,” Yu said.

The work is reported in the journal Science Advances.

Source: http://www.uh.edu/

Magnetic Cellular ‘Legos’ For Tissue Engineering

By incorporating magnetic nanoparticles in cells and developing a system using miniaturized magnets, researchers from 3 associated universities* in Paris (France) , have succeeded in creating cellular magneticLegos.” They were able to aggregate cells using only magnets and without an external supporting matrix, with the cells then forming a tissue that can be deformed at will. This approach, which is detailed in Nature Communications, could prove to be a powerful tool for biophysical studies, as well as the regenerative medicine of tomorrow.

Nanotechnology has quickly swept across the medical field by proposing sometimes unprecedented solutions at the furthest limits of current treatments, thereby becoming central to diagnosis and therapy, notably for the regeneration of tissue. A current challenge for regenerative medicine is to create a cohesive and organized cellular assembly without using an external supporting matrix. This is a particularly substantial challenge when it involves synthesizing thick and/or large-sized tissue, or when these tissues must be stimulated like their in vivo counterparts (such as cardiac tissue or cartilage) in order to improve their functionality.

The researchers met this challenge by using magnetism to act on the cells at a distance, in order to assemble, organize, and stimulate them. Cells, which are the building blocks of tissue, are thus magnetized in advance through the incorporation of magnetic nanoparticles, thus becoming true cellular magnetic “Legos” that can be moved and stacked using external magnets. In this new system acting as a magnetic tissue stretcher, the magnetized cells are trapped on a first micromagnet, before a second, mobile magnet traps the aggregate formed by the cells. The movement of the two magnets can stretch or compress the resulting tissue at will.

Researchers first used embryonic stem cells to test their system. They began by showing that the incorporation of nanoparticles had no impact on either the functioning of the stem cell or its capacity for differentiation. These functional magnetic stem cells were then tested in the stretcher, in which they remarkably differentiated toward cardiac cell precursors when stimulation imposed “magnetic beating” imitating the contraction of the heart. These results demonstrate the role that purely mechanical factors can play in cell differentiation.

This “all-in-one” approach, which makes it possible to build and manipulate tissue within the same system, could thus prove to be a powerful tool both for biophysical studies and tissue engineering.

* Laboratoire Matière et Systèmes Complexes (CNRS/Université Paris Diderot), in collaboration with the Laboratoire Adaptation Biologique et Vieillissement (CNRS/UPMC) and the Centre de Recherche Cardiovasculaire de Paris (Inserm/Université Paris Descartes)

Source: https://www.nature.com/
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Rapid, Cheap Liver Cancer Test

University of Utah researchers say they are designing a diagnostic method that will be able to accurately identify signs of liver cancer within minutes, saving critical time for patients of the stealthy disease. The new type of test could forever change how people screen for the disease, said Marc Porter, a U. chemical engineering and chemistry professor who is leading the research along with Dr. Courtney Scaife, a surgeon who both practices and teaches surgery for the university. Porter said the long-term vision is for the tool itself to become as automatic and portable as a pregnancy test, though additional technology — called a spectrometer — is currently needed to precisely measure the results of the test.

A small domino-sized cartridge holds a membrane for a new field test for liver cancer developed by researchers from the University of Utah. The test doesn’t involve sending a specimen to a blood lab and cuts the wait time for results from two weeks to two minutes. It can be administered wherever the patient is, which will be valuable for developing nations with little access to hospitals.

It’s really compact, it’s simple and low cost,” he said of the test kit.

Liver cancer is difficult to survive because typically it is highly developed by the time symptoms show up, Porter said. It is the second deadliest form of cancer worldwide, resulting in about 788,000 deaths in 2015, according to the World Health Organization. “All too often, the cancer is diagnosed past when you can actually have surgical intervention,” Porter said.

Currently, a blood test taken to determine the presence of liver cancer is usually sent to a lab offsite, where it takes days or even up to two weeks to test and return, said Vincent Horiuchi, spokesman for the U.’s College of Engineering. Those days are precious time that is lost in the fight against the disease, he said.

Source: https://unews.utah.edu/

How To Draw Electricity from the Bloodstream

Men build dams and huge turbines to turn the energy of waterfalls and tides into electricity. To produce hydropower on a much smaller scale, Chinese scientists have now developed a lightweight power generator based on carbon nanotube fibers suitable to convert even the energy of flowing blood in blood vessels into electricity.

For thousands of years, people have used the energy of flowing or falling water for their purposes, first to power mechanical engines such as watermills, then to generate electricity by exploiting height differences in the landscape or sea tides. Using naturally flowing water as a sustainable power source has the advantage that there are (almost) no dependencies on weather or daylight. Even flexible, minute power generators that make use of the flow of biological fluids are conceivable. How such a system could work is explained by a research team from Fudan University in Shanghai, China. Huisheng Peng and his co-workers have developed a fiber with a thickness of less than a millimeter that generates electrical power when surrounded by flowing saline solution—in a thin tube or even in a blood vessel.

The construction principle of the fiber is quite simple. An ordered array of carbon nanotubes was continuously wrapped around a polymeric core. Carbon nanotubes are well known to be electroactive and mechanically stable; they can be spun and aligned in sheets. In the as-prepared electroactive threads, the carbon nanotube sheets coated the fiber core with a thickness of less than half a micron. For power generation, the thread or “fiber-shaped fluidic nanogenerator” (FFNG), as the authors call it, was connected to electrodes and immersed into flowing water or simply repeatedly dipped into a saline solution. “The electricity was derived from the relative movement between the FFNG and the solution,” the scientists explained. According to the theory, an electrical double layer is created around the fiber, and then the flowing solution distorts the symmetrical charge distribution, generating an electricity gradient along the long axis.

The power output efficiency of this system was high. Compared with other types of miniature energy-harvesting devices, the FFNG was reported to show a superior power conversion efficiency of more than 20%. Other advantages are elasticity, tunability, lightweight, and one-dimensionality, thus offering prospects of exciting technological applications. The FFNG can be made stretchable just by spinning the sheets around an elastic fiber substrate. If woven into fabrics, wearable electronics become thus a very interesting option for FFNG application. Another exciting application is the harvesting of electrical energy from the bloodstream for medical applications. First tests with frog nerves proved to be successful.

The findings are published in  the journal Angewandte Chemie.

Source: http://newsroom.wiley.com/