How To Fight Against Weakened Immune System When Getting Older

Scientists pinpoint metabolic pathway behind age-related immunity lossThe elderly suffer more serious complications from infections and benefit less from vaccination than the general population. Researchers have long known that a weakened immune system is to blame but the exact mechanisms behind this lagging immunity have remained largely unknownNow research led by investigators at Harvard Medical School suggests that weakened metabolism of immune T cells may be partly to blame.

The findings, published Dec. 10 in PNAS and based on experiments in mouse immune cells, pinpoint a specific metabolic pathway called one-carbon metabolism that is deficient in the aged T cells of rodents. The work also suggests possible ways to restore weakened immune function with the use of small-molecule compounds that boost T cell performance.

We believe our findings may help explain the basic malfunction that drives loss of immune defenses with age,” said senior study author Marcia Haigis, professor of cell biology in the Blavatnik Institute at Harvard Medical School. “If affirmed in further studies, we hope that our findings can set the stage for the development of therapies to improve immune function.

Source: https://scienmag.com/

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