Posts belonging to Category cyborg



Gene Researchers Have Created Green Mice

These are no Frankenstein mice. Their green feet come courtesy of a fluorescent green jelly fish gene added to their own genome. This allows a team of British scientists to test out gene editing using CRISPR-Cas9 technology.

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“We take what were or would have been green embryos and we make them into non-green embryos, so it’s a really great way of demonstrating the method“, said Dr. Anthony Perry, reproductive biologist at the University of Bath.

The technique uses the ribonucleic acid molecule CRISPR together with the Cas9 protein enzyme. CRISPR guides the Cas9 protein to a defective part of a genome where it acts like molecular scissors to cut out a specific part of the DNA. This could revolutionise how we treat diseases with a genetic component, like sickle cell anaemia. The technique is being pioneered in the U.S.
We now have a technology that allows correction of a sequence that would lead to normally functioning cells. And I think you know the opportunities with this are really exciting and really profound. There are many diseases that are have known genetic causes that we now have in principle a way to cure,“explains Jennifer Doudna, Professor of cell biology at the University of Berkeley.
Last year two teams of U.S. based scientists used CRISPR-Cas9 technology in mice to correct the genetic mutation that causes sickle cell disease. Although researchers aren’t yet close to using CRISPR-Cas9 to edit human embryos for implantation into the womb – some are already warning against it.

Dr David King, Director of  Human Genetics Alert, comments: “It will immediately create this new form of what we call consumer eugenics, that’s to say eugenics driven by the free market and consumer preferences in which people choose the cosmetic characteristics and the abilities of their children and try to basically enhance their children to perform better than other people’s children.” Other potential applications of the technology could be to make food crops and livestock animal species disease-resistant. The British team say CRISPR-Cas9 presents a golden opportunity to prevent genetic disease.

Source: http://www.reuters.com/
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http://www.bath.ac.uk/

Robots With The Sense Of Touch

A team of researchers from the University of Houston (UH) has reported a breakthrough in stretchable electronics that can serve as an artificial skin, allowing a robotic hand to sense the difference between hot and cold, while also offering advantages for a wide range of biomedical devices.

Cunjiang Yu, Bill D. Cook Assistant Professor of mechanical engineering and lead author for the paper, said the work is the first to create a semiconductor in a rubber composite format, designed to allow the electronic components to retain functionality even after the material is stretched by 50 percent. The semiconductor in rubber composite format enables stretchability without any special mechanical structure. Yu noted that traditional semiconductors are brittle and using them in otherwise stretchable materials has required a complicated system of mechanical accommodations. “That’s both more complex and less stable than the new discovery, as well as more expensive.”

Our strategy has advantages for simple fabrication, scalable manufacturing, high-density integration, large strain tolerance and low cost,” he said.

Yu and the rest of the team – co-authors include first author Hae-Jin Kim, Kyoseung Sim and Anish Thukral, all with the UH Cullen College of Engineering – created the electronic skin and used it to demonstrate that a robotic hand could sense the temperature of hot and iced water in a cup. The skin also was able to interpret computer signals sent to the hand and reproduce the signals as .

The robotic skin can translate the gesture to readable letters that a person like me can understand and read,” Yu said.

The work is reported in the journal Science Advances.

Source: http://www.uh.edu/

Magnetic Cellular ‘Legos’ For Tissue Engineering

By incorporating magnetic nanoparticles in cells and developing a system using miniaturized magnets, researchers from 3 associated universities* in Paris (France) , have succeeded in creating cellular magneticLegos.” They were able to aggregate cells using only magnets and without an external supporting matrix, with the cells then forming a tissue that can be deformed at will. This approach, which is detailed in Nature Communications, could prove to be a powerful tool for biophysical studies, as well as the regenerative medicine of tomorrow.

Nanotechnology has quickly swept across the medical field by proposing sometimes unprecedented solutions at the furthest limits of current treatments, thereby becoming central to diagnosis and therapy, notably for the regeneration of tissue. A current challenge for regenerative medicine is to create a cohesive and organized cellular assembly without using an external supporting matrix. This is a particularly substantial challenge when it involves synthesizing thick and/or large-sized tissue, or when these tissues must be stimulated like their in vivo counterparts (such as cardiac tissue or cartilage) in order to improve their functionality.

The researchers met this challenge by using magnetism to act on the cells at a distance, in order to assemble, organize, and stimulate them. Cells, which are the building blocks of tissue, are thus magnetized in advance through the incorporation of magnetic nanoparticles, thus becoming true cellular magnetic “Legos” that can be moved and stacked using external magnets. In this new system acting as a magnetic tissue stretcher, the magnetized cells are trapped on a first micromagnet, before a second, mobile magnet traps the aggregate formed by the cells. The movement of the two magnets can stretch or compress the resulting tissue at will.

Researchers first used embryonic stem cells to test their system. They began by showing that the incorporation of nanoparticles had no impact on either the functioning of the stem cell or its capacity for differentiation. These functional magnetic stem cells were then tested in the stretcher, in which they remarkably differentiated toward cardiac cell precursors when stimulation imposed “magnetic beating” imitating the contraction of the heart. These results demonstrate the role that purely mechanical factors can play in cell differentiation.

This “all-in-one” approach, which makes it possible to build and manipulate tissue within the same system, could thus prove to be a powerful tool both for biophysical studies and tissue engineering.

* Laboratoire Matière et Systèmes Complexes (CNRS/Université Paris Diderot), in collaboration with the Laboratoire Adaptation Biologique et Vieillissement (CNRS/UPMC) and the Centre de Recherche Cardiovasculaire de Paris (Inserm/Université Paris Descartes)

Source: https://www.nature.com/
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https://eurekalert.org/

Faulty DNA Linked To Fatal Heart Condition Removed From Embryo

Scientists have modified human embryos to remove genetic mutations that cause heart failure in otherwise healthy young people in a landmark demonstration of the controversial procedure. It is the first time that human embryos have had their genomes edited outside China, where researchers have performed a handful of small studies to see whether the approach could prevent inherited diseases from being passed on from one generation to the next.

While none of the research so far has created babies from modified embryos, a move that would be illegal in many countries, the work represents a milestone in scientists’ efforts to master the technique and brings the prospect of human clinical trials one step closer. The work focused on an inherited form of heart disease, but scientists believe the same approach could work for other conditions caused by single gene mutations, such as cystic fibrosis and certain kinds of breast cancer.

This embryo gene correction method, if proven safe, can potentially be used to prevent transmission of genetic disease to future generations,” said Paula Amato, a fertility specialist involved in the US-Korean study at Oregon Health and Science University.

The scientists used a powerful gene editing tool called Crispr-Cas9 to fix mutations in embryos made with the sperm of a man who inherited a heart condition known as hypertrophic cardiomyopathy, or HCM. The disease, which leads to a thickening of the heart’s muscular wall, affects one in 500 people and is a common cause of sudden cardiac arrest in young people. Humans have two copies of every gene, but some diseases are caused by a mutation in only one of the copies. For the study, the scientists recruited a man who carried a single mutant copy of a gene called MYBPC3 which causes HCM.

Source: https://www.theguardian.com/

Nanoweapons Against North Korea

Unless you’re working in the field, you probably never heard about U.S. nanoweapons. This is intentional. The United States, as well as Russia and China, are spending billions of dollars per year developing nanoweapons, but all development is secret. Even after Pravda.ru’s June 6, 2016 headline, “US nano weapon killed Venezuela’s Hugo Chavez, scientists say,” the U.S. offered no response.

Earlier this year, May 5, 2017, North Korea claimed the CIA plotted to kill Kim Jong Un using a radioactive nano poison, similar to the nanoweapon Venezuelan scientists claim the U.S. used to assassinate former Venezuelan President Hugo Chavez. All major media covered North Korea’s claim. These accusations are substantial, but are they true? Let’s address this question.

Unfortunately, until earlier this year, nanoweapons gleaned little media attention. However, in March 2017 that changed with the publication of the book, Nanoweapons: A Growing Threat to Humanity (2017 Potomac Books), which inspired two articles. On March 9, 2017, American Security Today published “Nanoweapons: A Growing Threat to Humanity – Louis A. Del Monte,” and on March 17, 2017, CNBC published “Mini-nukes and mosquito-like robot weapons being primed for future warfare.” Suddenly, the genie was out of the bottle. The CNBC article became the most popular on their website for two days following its publication and garnered 6.5K shares. Still compared to other classes of military weapons, nanoweapons remain obscure. Factually, most people never even heard the term. If you find this surprising, recall most people never heard of stealth aircraft until their highly publicized use during the first Iraq war in 1990. Today, almost everyone that reads the news knows about stealth aircraft. This may become the case with nanoweapons, but for now, it remains obscure to the public.

Given their relative obscurity, we’ll start by defining nanoweapons. A nanoweapon is any military weapon that exploits the power of nanotechnology. This, of course, begs another question: What is nanotechnology? According to the United States National Nanotechnology Initiative’s website, nano.gov, “Nanotechnology is science, engineering, and technology conducted at the nanoscale, which is about 1 to 100 nanometers.” To put this in simple terms, the diameter of a typical human hair equals 100,000 nanometers. This means nanotechnology is invisible to the naked eye or even under an optical microscope.

Source: http://www.huffingtonpost.com/

Artificial Intelligence Checks Identity Using Any Smartphone

Checking your identity using simulated human cognition aiThenticate say their system goes way beyond conventional facial recognition systems or the biometrics of passwords, fingerprints and eyescans.

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We need to have a much greater level of a certainty who somebody actually is. In order to answer that question, we appealed to deep science, deep learning, to develop an AI method, artificial intelligence method, in other words to replicate or to mimic or to simulate the way that we as humans, intuitively and instinctively go by recognizing somebody’s head, is very different to the conventional traditional way of face recognition, finger print recognition, for that reason really represents the next generation of authentication technologies or methods,” says AiTthenticate CEO André Immelman.

aiDX uses 16 distinct tests to recognise someone – including eye prints using a standard off the shelf smart phone to access encrypted data stored in the cloud it can operate in active mode – asking the user taking a simple selfie or discreetly in the background.

André Immelman explains: “It has applications in the security sense, it has applications in a customer services sense, you know this kind of things the bank calls you up and says: this is your bank calling, please, where you live, what is your mother’s name, what’s your dog favourite hobby, whatever the case it may be. It takes that kind of guess work out of the equation completely and it answers the, “who” question to much greater levels of confidence or certainty, than what traditional or conventional biometrics have been able to do in the past.”

Billions of dollars a year are lost to identity theft globally. aiThenticate hope their new system can help stop at least some of that illegal trade.

Source: http://www.eyethenticate.za.com/
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http://www.reuters.com/

How To Repair Connections Between Nerve Cells

Carbon nanotubes exhibit interesting characteristics rendering them particularly suited to the construction of special hybrid devices – consisting of biological tissue and synthetic material – planned to re-establish connections between nerve cells, for instance at spinal level, lost on account of lesions or trauma. This is the result of a piece of research published on the scientific journal Nanomedicine: Nanotechnology, Biology, and Medicine conducted by a multi-disciplinary team comprising SISSA (International School for Advanced Studies), the University of Trieste, ELETTRA Sincrotrone and two Spanish institutions, Basque Foundation for Science and CIC BiomaGUNE. More specifically, researchers have investigated the possible effects on neurons of the interaction with carbon nanotubes. Scientists have proven that these nanomaterials may regulate the formation of synapses, specialized structures through which the nerve cells communicate, and modulate biological mechanisms, such as the growth of neurons, as part of a self-regulating process. This result, which shows the extent to which the integration between nerve cells and these synthetic structures is stable and efficient, highlights the great potentialities of carbon nanotubes as innovative materials capable of facilitating neuronal regeneration or in order to create a kind of artificial bridge between groups of neurons whose connection has been interrupted. In vivo testing has actually already begun.

Scientists have proven that these nanomaterials may regulate the formation of synapses, specialized structures through which the nerve cells communicate, and modulate biological mechanisms, such as the growth of neurons, as part of a self-regulating process

Interface systems, or, more in general, neuronal prostheses, that enable an effective re-establishment of these connections are under active investigation” explain Laura Ballerini (SISSA) and Maurizio Prato (UniTSCIC BiomaGUNE), coordinating the research project. “The perfect material to build these neural interfaces does not exist, yet the carbon nanotubes we are working on have already proved to have great potentialities. After all, nanomaterials currently represent our best hope for developing innovative strategies in the treatment of spinal cord injuries“. These nanomaterials are used both as scaffolds, a supportive framework for nerve cells, and as means of interfaces releasing those signals that empower nerve cells to communicate with each other.

Source: https://eurekalert.org/

Startup Promises Immortality Through AI, Nanotechnology, and Cloning

One of the things humans have plotted for centuries is escaping death, with little to show for it, until now. One startup called Humai has a plan to make immortality a reality. The CEO, Josh Bocanegra says when the time comes and all the necessary advancements are in place, we’ll be able to freeze your brain, create a new, artificial body, repair any damage to your brain, and transfer it into your new body. This process could then be repeated in perpetuityHUMAI stands for: Human Resurrection through Artificial Intelligence. The technology to accomplish this isn’t here now, but on the horizon. Bocanegra says they’ll reach this Promethean feat within 30 years. 2045 is currently their target date. So how do they plan to do it?

We’re using artificial intelligence and nanotechnology to store data of conversational styles, behavioral patterns, thought processes and information about how your body functions from the inside-out. This data will be coded into multiple sensor technologies, which will be built into an artificial body with the brain of a deceased human, explains the website.

Source: https://www.facebook.com/humaitech/
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http://bigthink.com/

The Rise Of The Cyborg

Researchers from UCLA and the University of Connecticut have designed a new biofriendly energy storage system called a biological supercapacitor, which operates using charged particles, or ions, from fluids in the human body. The device is harmless to the body’s biological systems, and it could lead to longer-lasting cardiac pacemakers and other implantable medical devices like artificial heart.

The UCLA team was led by Richard Kaner, a distinguished professor of chemistry and biochemistry, and of materials science and engineering, and the Connecticut researchers were led by James Rusling, a professor of chemistry and cell biology. A paper about their design was published this week in the journal Advanced Energy Materials.

Pacemakers — which help regulate abnormal heart rhythms — and other implantable devices have saved countless lives. But they’re powered by traditional batteries that eventually run out of power and must be replaced, meaning another painful surgery and the accompanying risk of infection. In addition, batteries contain toxic materials that could endanger the patient if they leak.

The researchers propose storing energy in those devices without a battery. The supercapacitor they invented charges using electrolytes from biological fluids like blood serum and urine, and it would work with another device called an energy harvester, which converts heat and motion from the human body into electricity — in much the same way that self-winding watches are powered by the wearer’s body movements. That electricity is then captured by the supercapacitor.

Combining energy harvesters with supercapacitors can provide endless power for lifelong implantable devices that may never need to be replaced,” said Maher El-Kady, a UCLA postdoctoral researcher and a co-author of the study.

Source: http://newsroom.ucla.edu/

Super-material Bends, Shapes And Focuses Sound Waves

These tiny 3D-printed bricks could one day allow people to create their own acoustics. That’s the plan of scientists from the universities of Bristol and Sussex. They’ve invented a metamaterial which bends and manipulates sound in any way the user wants. It’s helped scientists create what they call a ‘sonic alphabet‘.

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We have discovered that you just need 16 bricks to make any type of sound that you can imagine. You can shape the sound just with 16 of them, just like you create any words with just 26 letters,” says Dr. Gianluca Memoli, researcher at Interact Lab at University of Sussex.

DIY kits like this, full of batches of the 16 aural letters, could help users create a sound library, or even help people in the same car to hear separate things.

With our device what you can have is you can strap a static piece on top of existing speakers and they can direct sound in two different directions without any overlap. So the passengers can hear completely different information from the driver,” explains Professor Sri Subramanian Interact Lab at University of Sussex. This technology is more than five years away, but smaller versions could be used to direct medical ultrasound devices far sooner.  “In a year we could have a sleeve that we can put on top of already existing projects in the market and make them just a little bit better. For example, we can have a sleeve that goes on top of ultrasound pain relieving devices that are used for therapeutic pain,” he adds.
Researchers say spatial sound modulators will one day allow us to perform audible tasks previously unheard of.

Source: http://www.sussex.ac.uk/

College Student 3D Prints His Own Braces

Amos Dudley wears his skills in his smile. The digital design major has been straightening his top teeth for the past 16 weeks using clear braces he made himself.

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 “I’m still wearing the last one,” said Dudley . “The last one” refers to the twelfth and final straightening tray in his self-designed treatment. Dudley said he had braces when he was in junior high, but he didn’t wear his retainer as much as he should have, and his teeth shifted. Over time, Dudley discovered that he wasn’t smiling as much because he wasn’t happy with the way his teeth looked.

Name brand options for clear braces can cost up to $8,000, according to companies like Invisalign, Damon, and ClearCorrect. But the 24-year-old wanted to save money, so he found a way to manufacture his own for less than $60. The total cost is so low because he only had to pay for materials used to make the models of his teeth and the retainers. Even though he built his own 3D printer at home, he opted to use a high-end and more precise 3D printer at his school, New Jersey Institute of Technology.

He used NJIT’s equipment to scan and print models of his teeth, and mold non-toxic plastic around them to form the set of 12 clear braces. Dudley determined out how far he needed to move his teeth to correct the misalignment problems. Then divided it by the maximum recommended distance a tooth should travel to determine the design for each alignment tray. Orthodontists use a similar process. Researching the materials he needed and figuring out how teeth move was the most difficult part of Dudley’s orthodontic adventure. The most exciting was when he finally put the first aligner in his mouth. “It was very obvious which tooth [the tray] was putting pressure on,” he said. “I was sort of worried about accumulated error, but that wasn’t the case so that was a pretty glorious moment.

Source: http://money.cnn.com/

A Brain-computer Interface To Combat The Rise of AI

Elon Musk is attempting to combat the rise of artificial intelligence (AI) with the launch of his latest venture, brain-computer interface company NeuralinkLittle is known about the startup, aside from what has been revealed in a Wall Street Journal report, but says sources have described it as “neural lace” technology that is being engineered by the company to allow humans to seamlessly communicate with technology without the need for an actual, physical interface. The company has also been registered in California as a medical research entity because Neuralink’s initial focus will be on using the described interface to help with the symptoms of chronic conditions, from epilepsy to depression. This is said to be similar to how deep brain stimulation controlled by an implant helps  Matt Eagles, who has Parkinson’s, manage his symptoms effectively. This is far from the first time Musk has shown an interest in merging man and machine. At a Tesla launch in Dubai earlier this year, the billionaire spoke about the need for humans to become cyborgs if we are to survive the rise of artificial intelligence.

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Over time I think we will probably see a closer merger of biological intelligence and digital intelligence,”CNBC reported him as saying at the time. “It’s mostly about the bandwidth, the speed of the connection between your brain and the digital version of yourself, particularly output.” Transhumanism, the enhancement of humanity’s capabilities through science and technology, is already a living reality for many people, to varying degrees. Documentary-maker Rob Spence replaced one of his own eyes with a video camera in 2008; amputees are using prosthetics connected to their own nerves and controlled using electrical signals from the brain; implants are helping tetraplegics regain independence through the BrainGate project.

Former director of the United States Defense Advanced Research Projects Agency (DARPA), Arati Prabhakar, comments: “From my perspective, which embraces a wide swathe of research disciplines, it seems clear that we humans are on a path to a more symbiotic union with our machines.

Source: http://www.wired.co.uk/