Posts belonging to Category Life extension



Brain Cells Found To Control Aging

Scientists at Albert Einstein College of Medicine have found that stem cells in the brain’s hypothalamus govern how fast aging occurs in the body. The finding, made in mice, could lead to new strategies for warding off age-related diseases and extending lifespan. The hypothalamus was known to regulate important processes including growth, development, reproduction and metabolism. In a 2013 Nature paper, Einstein researchers made the surprising finding that the hypothalamus also regulates aging throughout the body. Now, the scientists have pinpointed the cells in the hypothalamus that control aging: a tiny population of adult neural stem cells, which were known to be responsible for forming new brain neurons.

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Our research shows that the number of hypothalamic neural stem cells naturally declines over the life of the animal, and this decline accelerates aging,” says senior author Dongsheng Cai, M.D., Ph.D., professor of molecular pharmacology at Einstein. “But we also found that the effects of this loss are not irreversible. By replenishing these stem cells or the molecules they produce, it’s possible to slow and even reverse various aspects of aging throughout the body.”

The findings have been published online in Nature.

Source: http://www.einstein.yu.edu/
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How To Generate Any Cell Within The Patient’s Own Body

Researchers at The Ohio State University Wexner Medical Center and Ohio State’s College of Engineering have developed a new technology, Tissue Nanotransfection (TNT), that can generate any cell type of interest for treatment within the patient’s own body. This technology may be used to repair injured tissue or restore function of aging tissue, including organs, blood vessels and nerve cells.

By using our novel nanochip technology (nanocomputer), injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining,” said Dr. Chandan Sen, director of Ohio State’s Center for Regenerative Medicine & Cell Based Therapies, who co-led the study with L. James Lee, professor of chemical and biomolecular engineering with Ohio State’s College of Engineering in collaboration with Ohio State’s Nanoscale Science and Engineering Center.

Researchers studied mice and pigs in these experiments. In the study, researchers were able to reprogram skin cells to become vascular cells in badly injured legs that lacked blood flow. Within one week, active blood vessels appeared in the injured leg, and by the second week, the leg was saved. In lab tests, this technology was also shown to reprogram skin cells in the live body into nerve cells that were injected into brain-injured mice to help them recover from stroke.

This is difficult to imagine, but it is achievable, successfully working about 98 percent of the time. With this technology, we can convert skin cells into elements of any organ with just one touch. This process only takes less than a second and is non-invasive, and then you’re off. The chip does not stay with you, and the reprogramming of the cell starts. Our technology keeps the cells in the body under immune surveillance, so immune suppression is not necessary,” said Sen, who also is executive director of Ohio State’s Comprehensive Wound Center.

Results of the regenerative medicine study have been published in the journal  Nature Nanotechnology.

Source: https://news.osu.edu/

Male Unfertility Rises Sharply In Developed World

Male fertility in the developed world is in sharp decline. A new study from the Hebrew University of Jerusalem shows a 52.4 percent fall in sperm concentration While total sperm count fell 59.3 percent between 1973 and 2011.

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Our findings of sharp decline in sperm count among western men is the canary in the coal mine. It signifies that we have a serious problem with the health of men in the western world,” says Hagai Levine, lead-researcher at Hebrew University-Hadassah School of Public Health.

That’s because sperm count is a marker of men’s general health as well as fertility. The study analysed sperm count studies from across the world – and the trend was reflected in America, Europe, Australia and New Zealand. The next step is to investigate the causes of male infertility.
From previous research we know that exposure to man-made chemicals, especially during the critical period of the development of the male reproductive system in pre-natal life, in the early stages of pregnancy can severaly disrupt and can manifest later in life as low sperm count and problems with male fertility,” explains Hagai Levine. The study controlled for factors like age, sexual activity and the types of men, making its conclusions more reliable. “So if, for example, you have 50 studies in one country and they all show the same trend in declining sperm counts, including different counting methods in different groups of men, that makes it much more likely that it’s real” states Prof. Daniel Brison, scientific Director at the University of Manchester (Dept. of Reproductive Health).

The decline shows no sign of slowing. And the researchers say further research is urgently needed – and regulation of the environmental factors that may be contributing could be part of the solution.

Source: https://academic.oup.com/
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Faulty DNA Linked To Fatal Heart Condition Removed From Embryo

Scientists have modified human embryos to remove genetic mutations that cause heart failure in otherwise healthy young people in a landmark demonstration of the controversial procedure. It is the first time that human embryos have had their genomes edited outside China, where researchers have performed a handful of small studies to see whether the approach could prevent inherited diseases from being passed on from one generation to the next.

While none of the research so far has created babies from modified embryos, a move that would be illegal in many countries, the work represents a milestone in scientists’ efforts to master the technique and brings the prospect of human clinical trials one step closer. The work focused on an inherited form of heart disease, but scientists believe the same approach could work for other conditions caused by single gene mutations, such as cystic fibrosis and certain kinds of breast cancer.

This embryo gene correction method, if proven safe, can potentially be used to prevent transmission of genetic disease to future generations,” said Paula Amato, a fertility specialist involved in the US-Korean study at Oregon Health and Science University.

The scientists used a powerful gene editing tool called Crispr-Cas9 to fix mutations in embryos made with the sperm of a man who inherited a heart condition known as hypertrophic cardiomyopathy, or HCM. The disease, which leads to a thickening of the heart’s muscular wall, affects one in 500 people and is a common cause of sudden cardiac arrest in young people. Humans have two copies of every gene, but some diseases are caused by a mutation in only one of the copies. For the study, the scientists recruited a man who carried a single mutant copy of a gene called MYBPC3 which causes HCM.

Source: https://www.theguardian.com/

New Brain Death Pathway In Alzheimer’s Identified

Findings of team led by the Arizona State University (ASU) scientists offer hope for therapies targeting cell loss in the brain, an inevitable and devastating outcome of Alzheimer’s progression
Alzheimer’s disease tragically ravages the brains, memories and, ultimately, personalities of its victims. Now affecting 5 million Americans, Alzheimer’s disease is the sixth-leading cause of death in the U.S., and a cure for Alzheimer’s remains elusive, as the exact biological events that trigger it are still unknown.

In a new study, Arizona State University-Banner Health neuroscientist Salvatore Oddo and his colleagues from Phoenix’s Translational Genomics Research Institute (TGen) — as well as the University of California, Irvine, and Mount Sinai in New York — have identified a new way for brain cells to become fated to die during Alzheimer’s disease. The research team has found the first evidence that the activation of a biological pathway called necroptosis, which causes neuronal loss, is closely linked with Alzheimer’s severity, cognitive decline and extreme loss of tissue and brain weight that are all advanced hallmarks of the disease.

We anticipate that our findings will spur a new area of Alzheimer’s disease research focused on further detailing the role of necroptosis and developing new therapeutic strategies aimed at blocking it,” said Oddo, the lead author of this study, and scientist at the ASU-Banner Neurodegenerative Disease Research Center at the Biodesign Institute and associate professor in the School of Life Sciences.

Necroptosis, which causes cells to burst from the inside out and die, is triggered by a triad of proteins. It has been shown to play a central role in multiple sclerosis and Lou Gehrig’s disease (amyotrophic lateral sclerosis, or ALS), and now for the first time, also in Alzheimer’s disease.

There is no doubt that the brains of people with Alzheimer’s disease have fewer neurons,” explained Oddo. “The brain is much smaller and weighs less; it shrinks because neurons are dying. That has been known for 100 years, but until now, the mechanism wasn’t understood.
The findings appear in the advanced online edition of Nature Neuroscience.

Source: https://asunow.asu.edu/

Multi-AntiOxidant Nanoparticles Fight Sepsis

With an incidence of 31.5 million worldwide and a mortality of around 17%, sepsis remains the most common cause of death in hospitalized patients, even in industrialized countries where antibiotics and critical care facilities are readily available. While this disease begins as a serious infection, sepsis‘ life-threatening organ failure is due to an excessive inflammatory response.

By overproducing oxygen free radicals, the immunity of the host itself paradoxically leads to an increase in morbidity and mortality. A team of researchers from Center for Nanoparticle Research, within the  (IBS), with colleagues from the Seoul National University Hospital synthesized nanoparticles with superior antioxidant properties to treat sepsis in rats and mice by removing harmful oxygen radicals and reducing inflammatory responses.

Under normal physiological conditions, oxygen radicals, also called reactive oxygen species (ROS), are created as by-products of several cellular reactions and their concentration is counterbalanced by antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT). However in patients with severe infections, the production of ROS as well as reactive nitrogen species (RNS), increases dramatically, while the body’s antioxidant capacity may be compromised. As a consequence, the ROS and RNS accumulation can lead to damages to DNA, proteins, and lipid membranes.

All major diseases are related to ROS,” explains HYEON Taeghwan, the director of the Center for Nanoparticle Research. “Cellular damage caused by ROS has been found not only in sepsis, but also in cancer, diabetes, cardiovascular disease, atherosclerosis, and neurodegenerative diseases, just to name a few.”

Ceria nanoparticles replace the function of antioxidant enzymes. Cerium trivalent ions (Ce3+) play a decisive role in eliminating ROS. Thanks to the addition of zirconium ions, the scientists could create a new type of nanoparticles, named 7CZ (containing 70% Ce ions and 30% Zr ions), with optimized nanoparticle size and Ce3+ content. The nanoparticles described in this study are smaller, just two nanometers in size. Moreover, they have a higher percent of Ce3+. When tested in mice with sepsis, the survival rate increased 2.5 fold in the 7CZ NP-treated group compared to the control. Scientists found that 7CZ nanoparticles can infiltrate the damaged tissue and act locally at the infection site.

Treating sepsis has been an old challenge for physicians worldwide,” emphasizes LEE Seung-Hoon, professor of department of Neurology, Seoul National University Hospital. “This study shows the possibility of overcoming the limits of modern medicine with nanotechnology.”

This study has been published in the journal Angewandte Chemie.

Source: ,http://www.ibs.re.kr/

Solar Nanotechnology-based Desalination

A new desalination system has been developed that combines membrane distillation technology and light-harvesting nanophotonics. Called nanophotonics-enabled solar membrane distillation technology, or NESMD for short, the development has come from the Center for Nanotechnology Enabled Water Treatment (NEWT), based at Rice University. The system works whereby hot salt water is flowed across one side of a porous membrane and cold freshwater is flowed across the otherWater vapor is naturally drawn through the membrane from the hot to the cold side, and because the seawater doesn’t need to be boiled, the energy requirements are less than they would be for traditional distillation, according to the researchers. However, the energy costs are still significant because heat is continuously lost from the hot side of the membrane to the cold.

Unlike traditional membrane distillation, NESMD benefits from increasing efficiency with scale,” said Rice’s Naomi Halas, a corresponding author on the paper and the leader of NEWT‘s  nanophotonics research efforts. “It requires minimal pumping energy for optimal distillate conversion, and there are a number of ways we can further optimise the technology to make it more productive and efficient.

The distillation membrane in the chamber contained a specially designed top layer of carbon black nanoparticles infused into a porous polymer. The light-capturing nanoparticles heated the entire surface of the membrane when exposed to sunlight. A thin half-millimeter-thick layer of salt water flowed atop the carbon-black layer, and a cool freshwater stream flowed below.

Rice scientist and water treatment expert Qilin Li said the water production rate increased greatly by concentrating the sunlight: “The intensity got up 17.5 kilowatts per meter squared when a lens was used to concentrate sunlight by 25 times, and the water production increased to about 6 liters per meter squared per hour.”

In the PNAS study, researchers offered proof-of-concept results based on tests with an NESMD chamber about the size of three postage stamps and just a few millimeters thick.

Source: http://www.waterworld.com/

Cancer: A Giant Step For Immunotherapy

A Food and Drug Administration (FDA) panel opened a new era in medicine, unanimously recommending that the agency approve the first-ever treatment that genetically alters a patient’s own cells to fight cancer, transforming them into what scientists call “a living drug” that powerfully bolsters the immune system to shut down the disease.

If the F.D.A. accepts the recommendation, which is likely, the treatment will be the first gene therapy ever to reach the market. Others are expected: Researchers and drug companies have been engaged in intense competition for decades to reach this milestone. Novartis is now poised to be the first. Its treatment is for a type of leukemia, and it is working on similar types of treatments in hundreds of patients for another form of the disease, as well as multiple myeloma and an aggressive brain tumor.

To use the technique, a separate treatment must be created for each patient — their cells removed at an approved medical center, frozen, shipped to a Novartis plant for thawing and processing, frozen again and shipped back to the treatment center.

A single dose of the resulting product has brought long remissions, and possibly cures, to scores of patients in studies who were facing death because every other treatment had failed. The panel recommended approving the treatment for B-cell acute lymphoblastic leukemia that has resisted treatment, or relapsed, in children and young adults aged 3 to 25.

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We believe that when this treatment is approved it will save thousands of children’s lives around the world,” Emily’s father, Tom Whitehead, told the panel. “I hope that someday all of you on the advisory committee can tell your families for generations that you were part of the process that ended the use of toxic treatments like chemotherapy and radiation as standard treatment, and turned blood cancers into a treatable disease that even after relapse most people survive.”

The main evidence that Novartis presented to the F.D.A. came from a study of 63 patients who received the treatment from April 2015 to August 2016. Fifty-two of them, or 82.5 percent, went into remission — a high rate for such a severe disease. Eleven others died.

It’s a new world, an exciting therapy,” said Dr. Gwen Nichols, the chief medical officer of the Leukemia and Lymphoma Society, which paid for some of the research that led to the treatment. The next step, she said, will be to determine “what we can combine it with and is there a way to use it in the future to treat patients with less disease, so that the immune system is in better shape and really able to fight.” She added, “This is the beginning of something big.”

Source: http://www.chop.edu/
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Blood Test for Early Detection of Pancreatic Cancer

A newly identified biomarker panel could pave the way to earlier detection and better treatment for pancreatic cancer, according to new research from the Perelman School of Medicine at University of Pennsylvania. Currently over 53,000 people in the United States are diagnosed with pancreatic cancer — the fourth leading cause of cancer death — every year. The blood biomarkers, detailed today in Science Translational Medicine, correctly detected pancreatic cancer in blood samples from patients at different stages of their disease.

The majority of pancreatic cancer patients are not diagnosed until an advanced stage, beyond the point at which their tumors can be surgically removed.

A team led by Ken Zaret, PhD, director of the Penn Institute for Regenerative Medicine and the Joseph Leidy Professor of Cell and Developmental Biology, and Gloria Petersen, PhD, from the Mayo Clinic, identified a pair of biomarkers that physicians could soon use to discover the disease earlier.

Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,” Zaret said. The authors anticipate that health care providers will use the early-detection biomarkers to test for their presence and levels in blood from pancreatic cancer patients and blood drawn from individuals with a high risk of developing pancreatic cancer, including those who have a first-degree relative with pancreatic cancer, are genetically predisposed to the disease, or who had a sudden onset of diabetes after the age of 50.

Early detection of cancer has had a critical influence on lessening the impact of many types of cancer, including breast, colon, and cervical cancer. A long standing concern has been that patients with pancreatic cancer are often not diagnosed until it is too late for the best chance at effective treatment,” said Robert Vonderheide, MD, DPhil, director of the Abramson Cancer Center (ACC) at the University of Pennsylvania. “Having a biomarker test for this disease could dramatically alter the outlook for these patients.”

Source: https://www.pennmedicine.org/

How To Re-Wire The Brains Of People With Depression

Doctors in California say magnetic stimulation can help ‘rewire‘ the brains of people with depression, offering hope for patients whose condition is not improved by medication or therapy. Depression is one of the most common forms of mental illness, affecting more than 350 million people worldwide. Bob Holmes is one of them.

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I struggled with that for many years, didn’t know really what to do, tried to pull myself through it. And then ultimately when I got into my forties, I wasn’t successful,” says Bob Holmes, who suffers from He has been receiving transcranial magnetic stimulation at the University of California Los Angeles (UCLA), a treatment that beams targeted magnetic pulses deep inside his brain. Doctors say the therapy can effectivelyrewire‘ the brain by changing how brain circuits are arranged.

(SOUNDBITE) (English) ANDREW LEUCHTER, DIRECTOR OF THE SEMEL INSTITUTE’S TMS CLINICAL AND RESEARCH SERVICE AT THE UNIVERSITY OF CALIFORNIA LOS ANGELES, SAYING:

By pulsing it with energy repeatedly, we’re changing the way that area works, but also changing the way the whole brain network works,” explains Andrew Leuchter,Director of the Semel Institute (UCLA).

For Holmes, the treatment has been life changing.  “I would recommend it a hundred percent. I have spoken to a number of people who have depression, given them my opinion, and I think it’s a wonderful program. It’s been a life-saver for me, and I’m very grateful that I found it, and I’m very grateful for the people here,” adds Holmes.

Doctors hope the newest generation of equipment could decrease the length of a treatment session from over 35 minutes down to three minutes, allowing a patient to complete a course in two weeks and bringing the therapy to even more people with depression.

Source: http://newsroom.ucla.edu/
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Dialysis Membrane Made From Graphene

Dialysis, in the most general sense, is the process by which molecules filter out of one solution, by diffusing through a membrane, into a more dilute solution. Outside of hemodialysis, which removes waste from blood, scientists use dialysis to purify drugs, remove residue from chemical solutions, and isolate molecules for medical diagnosis, typically by allowing the materials to pass through a porous membrane.

Today’s commercial dialysis membranes separate molecules slowly, in part due to their makeup: They are relatively thick, and the pores that tunnel through such dense membranes do so in winding paths, making it difficult for target molecules to quickly pass through.

Now MIT engineers have fabricated a functional dialysis membrane from a sheet of graphene — a single layer of carbon atoms, linked end to end in hexagonal configuration like that of chicken wire. The graphene membrane, about the size of a fingernail, is less than 1 nanometer thick. (The thinnest existing memranes are about 20 nanometers thick.) The team’s membrane is able to filter out nanometer-sized molecules from aqueous solutions up to 10 times faster than state-of-the-art membranes, with the graphene itself being up to 100 times faster.

While graphene has largely been explored for applications in electronics, Piran Kidambi, a postdoc in MIT’s Department of Mechanical Engineering, says the team’s findings demonstrate that graphene may improve membrane technology, particularly for lab-scale separation processes and potentially for hemodialysis.

Because graphene is so thin, diffusion across it will be extremely fast,” Kidambi says. “A molecule doesn’t have to do this tedious job of going through all these tortuous pores in a thick membrane before exiting the other side. Moving graphene into this regime of biological separation is very exciting.”

Kidambi is a lead author of a study reporting the technology, published today in Advanced Materials. Six co-authors are from MIT, including Rohit Karnik, associate professor of mechanical engineering, and Jing Kong, associate professor of electrical engineering.

Source: http://news.mit.edu/

The Fountain Of Youth

It’s been a dream of civilizations since the dawn of time: If we can’t live forever, can we at least slow down the aging process and stretch our lives out as long as possible? Now, researchers from Brigham Young University (BYU) say they’ve found that a certain type of physical exercise can slow the aging process within our cells. That ultimately means better health, and physical conditioning that matches the natural age progression of a significantly younger person–as many as nine years younger.

105 years old Champion French cyclist

If it’s not quite the fountain of youth, it’s an intriguing step toward it. I’m also the first to admit that such a big claim deserves a skeptical eye. So let’s dive right into the study and examine what the researchers claim–along with exactly how much exercise we’re talking about here to achieve the results.

 

Researchers at BYU, led by a professor of exercise science named Larry Tucker, studied 5,823 adults who had participated in a Centers for Disease Control and Prevention (CDC) research project called the National Health and Nutrition Examination Survey. Among many other things, this study kept track of the participants’ daily physical activity. Specifically, it tracked the degree to which these people engaged in 62 types of exercise over a 30-day period.

The CDC study also measured something called “telomere length values.” Telomeres are “the nucleotide endcaps of our chromosomes,” as a BYU press release explained it, continuing: They’re like our biological clock and they’re extremely correlated with age; each time a cell replicates, we lose a tiny bit of the endcaps. Therefore, the older we get, the shorter our telomeres.

Here’s where it gets interesting. By poring through the data in the CDC study, BYU‘s Tucker claims that he was able to correlate people’s relative telomere length with their various levels of physical activity–and he found a surprise. If you think of people’s levels of physical activity as being in four categoriessedentary, low, moderate, and high–Tucker found that people in the first three categories had roughly similar telomere lengths.

But for that last category, the people who engaged in high levels of physical activity had “140 base pairs of DNA [more] at the end of their telomeres” than everyone else. According to Tucker’s paper, which was published in the July 2017 edition of Preventive Medicine, that results in a “biologic aging advantage of nine years.” To put this plainly and in layman’s terms, engage in high levels of physical activity, and your cells are more likely to resemble the cells of a considerably younger person. The BYU researchers had to draw a line somewhere, so for purposes of their study they defined “high levels of physical activity” to mean engaging in 30 minutes of jogging for women, or 40 minutes of jogging for men–and to do it five days per week. That’s the kind of level that requires a commitment, but probably isn’t beyond the abilities of anyone who wants to make a decision to become healthier. And, of course, this isn’t the first study by any means to attempt to find the link between increased exercise, better health, and longer life.

Recently, for example, researchers at the Mayo Clinic reached a similar conclusion for different reasons, finding that people who engaged regularly in high-intensity interval training had cells that were more efficient at creating new proteins–which in turn results in “reversing a major adverse effect of aging.”

Source: https://magazine.byu.edu/
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