Posts belonging to Category biomolecular



Artificial Intelligence At The Hospital

Diagnosing cancer is a slow and laborious process. Here researchers at University Hospital Zurich painstakingly make up biopsy slides – up to 50 for each patient – for the pathologist to examine for signs of prostate cancer. A pathologist takes around an hour and a half per patient – a task IBMs Watson supercomputer is now doing in fractions of a second.

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“If the pathologist becomes faster by using such a system I think it will pay off. Because my time is also worth something. If I sit here one and a half hours looking at slides, screening all these slides, instead of just signing out the two or three positive ones, and taking into account that there may be a .1 error rate, percent error rate. this will pay off, because I can do in one and a half hours at the end five patients,” says Dr. Peter Wild, University Hospital Zürich.

The hospital’s archive of biopsy images is being slowly fed into Watson – a process that will take years. But maybe one day pathologists won’t have to view slides through a microscope at all. Diagnosis is not the only area benefiting from AI. The technology is helping this University of Sheffield team design a new drug that could slow down the progress of motor neurone disease. A system built by British start-up BenevolentAI is identifying new areas for further exploration far faster than a person could ever hope to.

Benevolent basically uses their artificial intelligence system to scan the whole medical and biomedical literature. It’s not really easy for us to stay on top of millions of publications that come out every year. So they can interrogate that information, using artificial intelligence and come up with ideas for new drugs that might be used in a completely different disease, but may be applicable on motor neurone disease. So that’s the real benefit in their system, the kind of novel ideas that they come up with,” explains Dr. Richard Mead, Sitran, University of Sheffield. BenevolentAI has raised one hundred million dollars in investment to develop its AI system, and help revolutionise the pharmaceutical industry.

Source: http://www.reuters.com/

Skin Regeneration

A small U.S. biotech has successfully regenerated skin and stimulated hair growth in pigs with burns and abrasions, paving the way for a scientific breakthrough that could lead to the regeneration of fully functional human skinSalt Lake City-based PolarityTE Inc‘s patented approach to tissue engineering is designed to use a patient’s own healthy tissue to re-grow human skin for the treatment of burns and wounds. Despite recent advances in reconstructive surgery, plastic surgeons cannot give burn victims what they require the most — their skin. Current approaches to treat serious burns are “severely limited” in their effectiveness and in some cases, are rather expensive, PolarityTE‘s founder and CEO Denver Lough said in an interview.

Epicel, a skin graft widely used in burn units that is sold by Cambridge, Massachusetts-based Vericel Corp, does not result in fully thick and functional skin — which is PolarityTE‘s objective.

“If clinically successful, the PolarityTE platform could deliver the first scientific breakthrough in wound healing and reconstructive surgery in nearly half a century,” said Lough, who served as senior plastic surgery resident at Johns Hopkins Hospital before creating PolarityTE last year.

“PolarityTE expects to begin a human trial later this year and the cell therapy could hit the market 12 to 18 months thereafter”.

PolarityTE conducted its pre-clinical study on wounded pigs at an animal facility in Utah. The use of therapy resulted in scar-less healing, growth of hair follicles, complete wound coverage and the progressive regeneration of all skin layers, the company said. As pig skin is more complex and robust than human skin, successful swine data is typically seen as a precursor to effectiveness in human trials.

The technology also has the potential to develop fully-functional tissues, including bone, muscle, cartilage and the liver, PolarityTE said.

Source: http://www.polarityte.com/
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http://www.reuters.com/

A Single Drop Of Blood To Test Agressive Prostate Cancer

A new diagnostic developed by Alberta scientists will allow men to bypass painful biopsies to test for aggressive prostate cancer. The test incorporates a unique nanotechnology platform to make the diagnostic using only a single drop of blood, and is significantly more accurate than current screening methods.

The Extracellular Vesicle Fingerprint Predictive Score (EV-FPS) test uses machine learning to combine information from millions of cancer cell nanoparticles in the blood to recognize the unique fingerprint of aggressive cancer. The diagnostic, developed by members of the Alberta Prostate Cancer Research Initiative (APCaRI), was evaluated in a group of 377 Albertan men who were referred to their urologist with suspected prostate cancer. It was found that EV-FPS correctly identified men with aggressive prostate cancer 40 percent more accurately than the most common test—Prostate-Specific Antigen (PSA) blood test—in wide use today.

Higher sensitivity means that our test will miss fewer aggressive cancers,” said John Lewis, the Alberta Cancer Foundation‘s Frank and Carla Sojonky Chair of Prostate Cancer Research at the University of Alberta. “For this kind of test you want the sensitivity to be as high as possible because you don’t want to miss a single cancer that should be treated.”

According to the team, current tests such as the PSA and digital rectal exam (DRE) often lead to unneeded biopsies. Lewis says more than 50 per cent of men who undergo biopsy do not have prostate cancer, yet suffer the pain and side effects of the procedure such as infection or sepsis. Less than 20 per cent of men who receive a are diagnosed with the aggressive form of prostate cancer that could most benefit from treatment.

It’s estimated that successful implementation of the EV-FPS test could eventually eliminate up to 600-thousand unnecessary biopsies, 24-thousand hospitalizations and up to 50 per cent of unnecessary treatments for prostate each year in North America alone. Beyond cost savings to the health care system, the researchers say the diagnostic test will have a dramatic impact on the health care experience and quality of life for men and their families.

Compared to elevated total PSA alone, the EV-FPS test can more accurately predict the result of prostate biopsy in previously unscreened men,” said Adrian Fairey, urologist at the Northern Alberta Urology Centre and member of APCaRI. “This information can be used by clinicians to determine which men should be advised to undergo immediate prostate biopsy and which men should be advised to defer and continue screening.”

Source:  https://medicalxpress.com/

Farming in Brooklyn

Erik Groszyk used to spend all day at his desk working as an investment banker. Now he cultivates his own urban farm out of a 40-foot shipping container in a Brooklyn parking lot.

I just found myself not satisfied and kind of yearning for more,’ says Erik Groszyk.  The Harvard grad is one of 10 ‘entrepreneurial farmers,’ selected from a batch of 500 applicants, working with Square Roots, an indoor urban farming company launched in November that grows local food year-round in the heart of New York City. Now, six months into the program, Groszyk said his training in farming, artificial lighting, water chemistry and nutrient balance allows him to harvest roughly 15 to 20 pounds of produce each week.

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People have lost trust in the food system, right? They want real food where they know their farmer, they know where their food is coming from, and they trust their food,‘ explains Tobias Peggs, Square Roots co-founder. He, along with his co-founder Kimbal Musk, the younger brother of Tesla‘s Elon Musk, aim to spread out to as many American cities as they possibly can in the next five to 10 years.

By 2050 there will be nine billion people on the planet and 70 percent will leave in urban areas. These people need feeding, and they will want local, real food,” he adds.
Square Roots sells food locally. It also plans to launch more urban farms, for others to operate, and will own a share in those farms’ revenues as well. Peggs says the company, by getting hyper-local, is looking to join a global food revolution. ‘America’s is the world’s great, greatest exporter. Right? We exported rock and roll, we exported Levi’s jeans. We also exported obesity. And the feeling is, if we can solve that, in America, through initiatives like Square Roots, bringing real food to everyone, getting more people on a healthy, low-cost, sustainable food system, that we’ll also be able to export that solution.’

Source: https://squarerootsgrow.com/
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http://www.reuters.com/

How Yo Make Sea Water Drinkable

Graphene-oxide membranes have attracted considerable attention as promising candidates for new filtration technologies. Now the much sought-after development of making membranes capable of sieving common salts has been achieved. New research demonstrates the real-world potential of providing clean drinking water for millions of people who struggle to access adequate clean water sources. Graphene-oxide membranes developed at the National Graphene Institute have already demonstrated the potential of filtering out small nanoparticles, organic molecules, and even large salts. Until now, however, they couldn’t be used for sieving common salts used in desalination technologies, which require even smaller sieves. Previous research at The University of Manchester found that if immersed in water, graphene-oxide membranes become slightly swollen and smaller salts flow through the membrane along with water, but larger ions or molecules are blocked.

The Manchester-based group have now further developed these graphene membranes and found a strategy to avoid the swelling of the membrane when exposed to water. The pore size in the membrane can be precisely controlled which can sieve common salts out of salty water and make it safe to drink.

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Realisation of scalable membranes with uniform pore size down to atomic scale is a significant step forward and will open new possibilities for improving the efficiency of desalination technology,” says Professor Rahul Raveendran Nair.

The new findings from a group of scientists at The University of Manchester have been published in the journal Nature Nanotechnology.

Source: http://www.manchester.ac.uk/
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http://www.reuters.com/

Powerful Anti-Aging Cream Using Nanotechnology

Wrinkle-smoothing hyaluronic acid can now be introduced into the skin without injections, thanks to an Israeli research team that spent years developing a nanotechnology for this purpose. Facial wrinkles, lines and sagging result from the body’s gradual loss of its ability to produce hyaluronic acid. In the past, treatments of hyaluronic acid couldn’t get into the skin’s deepest layers except by injection or in a powder form that must be mixed with water and therefore loses its potency.

That problem was solved by a research team headed by Prof. Rachel Lubart and Prof. Aharon Gedanken from the departments of chemistry and physics and Bar-Ilan University’s Institute for Nanotechnology and Advanced Materials (BINA). The Israeli scientists achieved this breakthrough by micronizingbreaking down its particles to the size of a micronhyaluronic acid. Based on this development, Israeli cosmetic pharmaceuticals pioneer Hava Zingboim has created Prophecy, the first-ever cream formula that allows hyaluronic acid to penetrate into the deeper skin layers.

Once they reach nano size, the hyaluronic acid molecules are transferred into the formula, which enables them to remain nano-sized throughout the process. The effect of the micronized hyaluronic acid applied to the skin is identical to the effect achieved when injecting hyaluronic acid into the skin, with the benefits of enhanced skin texture and a younger look.
According to a university statement, this is the only technology in the world capable of creating small molecules that remain small even when applied to the skin.

Source: https://www.israel21c.org/
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http://reshet.tv/

Startup Promises Immortality Through AI, Nanotechnology, and Cloning

One of the things humans have plotted for centuries is escaping death, with little to show for it, until now. One startup called Humai has a plan to make immortality a reality. The CEO, Josh Bocanegra says when the time comes and all the necessary advancements are in place, we’ll be able to freeze your brain, create a new, artificial body, repair any damage to your brain, and transfer it into your new body. This process could then be repeated in perpetuityHUMAI stands for: Human Resurrection through Artificial Intelligence. The technology to accomplish this isn’t here now, but on the horizon. Bocanegra says they’ll reach this Promethean feat within 30 years. 2045 is currently their target date. So how do they plan to do it?

We’re using artificial intelligence and nanotechnology to store data of conversational styles, behavioral patterns, thought processes and information about how your body functions from the inside-out. This data will be coded into multiple sensor technologies, which will be built into an artificial body with the brain of a deceased human, explains the website.

Source: https://www.facebook.com/humaitech/
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http://bigthink.com/

Asthma: Graphene-Based Sensor Improves Treatment

Scientists from Rutgers University have created a graphene-based sensor that could lead to earlier detection of looming asthma attacks and improve the management of asthma and other respiratory diseases, preventing hospitalizations and deaths.

The sensor paves the way for the development of devices – possibly resembling fitness trackers like the Fitbit – which people could wear and then know when and at what dosage to take their medication.


Exhaled breath condensate (tiny droplets of liquid) are rapidly analyzed by a graphene-based nanoelectronic sensor that detects nitrite, a key inflammatory marker in the inner lining of the respiratory airway.

Our vision is to develop a device that someone with asthma or another respiratory disease can wear around their neck or on their wrist and blow into it periodically to predict the onset of an asthma attack or other problems,” said Mehdi Javanmard, an assistant professor in the Department of Electrical and Computer Engineering. “It advances the field of personalized and precision medicine.

Javanmard and a diverse team of RutgersNew Brunswick experts describe their invention in a study published online today in the journal Microsystems & Nanoengineering.

Asthma, which causes inflammation of the airway and obstructs air flow, affects about 300 million people worldwide. About 17.7 million adults and 6.3 million children in the United States were diagnosed with asthma in 2014. Symptoms include coughing, wheezing, shortness of breath, and chest tightness. Other serious lung ailments include chronic obstructive pulmonary disease (COPD), which encompasses emphysema and chronic bronchitis.

Measuring biomarkers in exhaled breath condensatetiny liquid droplets discharged during breathing – can contribute to understanding asthma at the molecular level and lead to targeted treatment and better disease management. The Rutgers researchers’ miniaturized electrochemical sensor accurately measures nitrite in exhaled breath condensate using reduced graphene oxide. Reduced graphene oxide resists corrosion, has superior electrical properties and is very accurate in detecting biomarkers.

Source: http://news.rutgers.edu/

Harvest: How To Increase The Production By Up To 40%

Nanolabs, a company specialised in nanotechnology, has been able to increase the production of melons by up to 40% on a farm in Almeria (Spain), thanks to the installation of ASAR systems in the irrigation system of the farm.
In 2015, 30,000 kilos were harvested, while in the same period of 2016, this figure increased to 50,000 kilos; a 40% growth.
To achieve this, Nanolabs applies nanotechnology through its ASAR solution, which acts physically on water, emitting a quantum of energy that stimulates hydrogen bonds. As a result, these become more active, which translates into a better transport of nutrients to the crops and a significant improvement in the use of the nutrients present in the substrate. The increase in production has not been the only benefit of the project; it has also made it possible to improve the quality of the fruit and has reduced both the consumption of water for irrigation and the use of fertilisers and phytosanitary products by 20%.
For Javier Llanes, CEO of Nanolabs, “the dramatic increase in the melon production is just one example of the great benefits that nanotechnology can bring to the agricultural sector. At Nanolabs, we apply technology to promote sustainability and we work on innovative projects with impressive results in both production improvement and savings in water consumption.”

Source: http://www.freshplaza.com/

Coral That Beats Global Warming

Coral reefs in the Red Sea’s Gulf of Aqaba can resist rising water temperatures. If they survive local pollution, these corals may one day be used to re-seed parts of the world where reefs are dying. The scientists urge governments to protect the Gulf of Aqaba ReefsCoral reefs are dying on a massive scale around the world, and global warming is driving this extinction. The planet’s largest reef, Australia’s Great Barrier Reef, is currently experiencing enormous coral bleaching for the second year in a row, while last year left only a third of its 2300-km ecosystem unbleached. The demise of coral reefs heralds the loss of some of the planet’s most diverse ecosystems. Scientists have shown that corals in the Gulf of Aqaba in the Northern Red Sea are particularly resistant to the effects of global warming and ocean acidification. The implications are important, as the Gulf of Aqaba is a unique coral refuge. The corals may provide the key to understanding the biological mechanism that leads to thermal resistance, or the weakness that underlies massive bleaching. There is also the hope that the Gulf of Aqaba Reefs could be used to re-seed deteriorated reefs in the Red Sea and perhaps even around the world.

Scientists at EPFL (Ecole polytechnique fédérale de Lausanne) and UNIL (Université de Lausanne) in Switzerland, and Bar Ilan University and the InterUniversity Institute of Marine Sciences in Israel, performed the very first detailed physiological assessment of corals taken from the Gulf of Aqaba after exposure to stressful conditions over a six-week period. They found that the corals did not bleach.

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Under these conditions,  most corals around the world would probably bleach and have a high degree of mortality,” says EPFL scientist Thomas Krueger. “Most of the variables that we measured actually improved, suggesting that these corals are living under suboptimal temperatures right now and might be better prepared for future ocean warming.”

The results are published today in the journal Royal Society Open Science.

Source: https://actu.epfl.ch/

Blood Cells Deliver Drugs To Kill Cancer

For the first time, WSU researchers have demonstrated a way to deliver a drug to a tumor by attaching it to a blood cell. The innovation could let doctors target tumors with anticancer drugs that might otherwise damage healthy tissues.

To develop the treatment, a team led by Zhenjia Wang, an assistant professor of pharmaceutical sciences, worked at the microscopic scale using a nanotherapeutic particle so small that 1,000 of them would fit across the width of a hair. By attaching a nanoscale particle to an infection-fighting white blood cell, the team showed they can get a drug past the armor of blood vessels that typically shield a tumor. This has been a major challenge in nanotechnology drug delivery.

Working with colleagues in Spokane and China, Wang implanted a tumor on the flank of a mouse commonly chosen as a model for human diseases. The tumor was exposed to near-infrared light, causing an inflammation that released proteins to attract white blood cells, called neutrophils, into the tumor. The researchers then injected the mouse with gold nanoparticles treated with antibodies that mediate the union of the nanoparticles and neutrophils. When the tumor was exposed to infrared light, the light’s interaction with the gold nanoparticles produced heat that killed the tumor cells, Wang said. In the future, therapists could attach an anticancer drug like doxorubicin to the nanoparticle. This could let them deliver the drug directly to the tumor and avoid damaging nearby tissues, Wang said.

We have developed a new approach to deliver therapeutics into tumors using the white blood cells of our body,” Wang said. “This will be applied to deliver many anticancer drugs, such as doxorubicin, and we hope that it could increase the efficacy of cancer therapies compared to other delivery systems.”

Wang and Chu’s colleagues on the research are postdoctoral researcher Dafeng Chu, Ph.D. student Xinyue Dong, Jingkai Gu of Jilin University and Jingkai Gu of the University of Macau.

The researchers reported on the technique in the latest issue of the journal Advanced Materials.

Source: https://news.wsu.edu/

The Rise Of The Cyborg

Researchers from UCLA and the University of Connecticut have designed a new biofriendly energy storage system called a biological supercapacitor, which operates using charged particles, or ions, from fluids in the human body. The device is harmless to the body’s biological systems, and it could lead to longer-lasting cardiac pacemakers and other implantable medical devices like artificial heart.

The UCLA team was led by Richard Kaner, a distinguished professor of chemistry and biochemistry, and of materials science and engineering, and the Connecticut researchers were led by James Rusling, a professor of chemistry and cell biology. A paper about their design was published this week in the journal Advanced Energy Materials.

Pacemakers — which help regulate abnormal heart rhythms — and other implantable devices have saved countless lives. But they’re powered by traditional batteries that eventually run out of power and must be replaced, meaning another painful surgery and the accompanying risk of infection. In addition, batteries contain toxic materials that could endanger the patient if they leak.

The researchers propose storing energy in those devices without a battery. The supercapacitor they invented charges using electrolytes from biological fluids like blood serum and urine, and it would work with another device called an energy harvester, which converts heat and motion from the human body into electricity — in much the same way that self-winding watches are powered by the wearer’s body movements. That electricity is then captured by the supercapacitor.

Combining energy harvesters with supercapacitors can provide endless power for lifelong implantable devices that may never need to be replaced,” said Maher El-Kady, a UCLA postdoctoral researcher and a co-author of the study.

Source: http://newsroom.ucla.edu/