New ‘Recipe’ To Produce Easily Nanoparticles

In a rare move, a Houston Methodist researcher is sharing his recipe for a new, more affordable way to make nanoparticles. This will empower any laboratory in the world to easily create similar nanoparticles and could lead to a whole new way of delivering biotherapeutic drugs and do it more quickly.

We’re the only lab in the world doing this,” said Ennio Tasciotti, Ph.D., director of the Center for Biomimetic Medicine at the Houston Methodist Research Institute and corresponding author on a paper published in Advanced Materials. “There are several questions about how our system works, and I can’t answer all of them. By giving away the so-called ‘recipe’ to make biomimetic nanoparticles, a lot of other labs will be able to enter this field and may provide additional solutions and applications that are beyond the reach of only one laboratory. You could say it’s the democratization of nanotechnology.

In the article, Tasciotti and his colleagues show how to standardize nanoparticle production to guarantee stability and reproducibility, while increasing yield. Eliminating the need for multi-million-dollar facilities, Tasciotti and his team demonstrate this using a readily available and relatively affordable piece of benchtop equipment to manufacture nanoparticles in a controlled, adjustable and low-cost manner.

Nanoparticles are generally made through cryptic protocols, and it’s very often impossible to consistently or affordably reproduce them,” Tasciotti added. “You usually need special, custom-made equipment or procedures that are available to only a few laboratories. We provide step-by-step instructions so that now everybody can do it.”