Nanoscale Memory Cell

Developing a superconducting computer that would perform computations at high speed without heat dissipation has been the goal of several research and development initiatives since the 1950s. Such a computer would require a fraction of the energy current supercomputers consume, and would be many times faster and more powerful. Despite promising advances in this direction over the last 65 years, substantial obstacles remain, including in developing miniaturized low-dissipation memory.

Researchers at the University of Illinois at Urbana-Champaign have developed a new nanoscale memory cell that holds tremendous promise for successful integration with superconducting processors. The new technology, created by Professor of Physics Alexey Bezryadin and graduate student Andrew Murphy, in collaboration with Dmitri Averin, a professor of theoretical physics at State University of New York at Stony Brook, provides stable memory at a smaller size than other proposed memory devices.

The device comprises two superconducting nanowires, attached to two unevenly spaced electrodes that were “written” using electron-beam lithography. The nanowires and electrodes form an asymmetric, closed superconducting loop, called a nanowire ‘SQUID’ (superconducting quantum interference device). The direction of current flowing through the loop, either clockwise or counterclockwise, equates to the “0” or “1” of binary code.

This is very exciting. Such superconducting memory cells can be scaled down in size to the range of few tens of nanometers, and are not subject to the same performance issues as other proposed solutions,” comments Bezryadin.

Murphy adds, “Other efforts to create a scaled-down superconducting memory cell weren’t able to reach the scale we have. A superconducting memory device needs to be cheaper to manufacture than standard memory now, and it needs to be dense, small, and fast.”


Ultrafast Flexible Electronic Memory

Engineering experts from the University of Exeter (UK) have developed innovative new memory using a hybrid of graphene oxide and titanium oxide. Their devices are low cost and eco-friendly to produce, are also perfectly suited for use in flexible electronic devices such as ‘bendablemobile phone, computer and television screens, and even ‘intelligentclothing.
. Crucially, these devices may also have the potential to offer a cheaper and more adaptable alternative to ‘flash memory’, which is currently used in many common devices such as memory cards, graphics cards and USB computer drives. The research team insist that these innovative new devices have the potential to revolutionise not only how data is stored, but also take flexible electronics to a new age in terms of speed, efficiency and power.

bendable mobile phone

Using graphene oxide to produce memory devices has been reported before, but they were typically very large, slow, and aimed at the ‘cheap and cheerful’ end of the electronics goods market”, said Professor David Wright, an Electronic Engineering expert from the University of Exeter.

Our hybrid graphene oxide-titanium oxide memory is, in contrast, just 50 nanometres long and 8 nanometres thick and can be written to and read from in less than five nanoseconds – with one nanometre being one billionth of a metre and one nanosecond a billionth of a second.”

The research is published in the scientific journal ACS Nano.


Transplant New Brain Cells And Forget Alzheimer’s

A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer’s disease, improving cognition to normal levels in aged mice.

In the study, which was conducted in collaboration with researchers at UC San Francisco and published in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors—early-stage brain cells that have the capacity to develop into mature inhibitory neurons—into two mouse models of Alzheimer’s disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer’s. The transplants helped to replenish the brain by replacing cells lost due to apoE4, regulating brain activity and improving learning and memory abilities.

Brain Cells

This is the first time transplantation of inhibitory neuron progenitors has been used in aged Alzheimer’s disease models,” said first author Leslie Tong, a graduate student at the Gladstone Institutes and UCSF. “Working with older animals can be challenging from a technical standpoint, and it was amazing to see that the cells not only survived but affected activity and behavior.

The success of the treatment in older mice, which corresponded to late adulthood in humans, is particularly important, as this would be the age that would be targeted were this method ever to be used therapeutically in people.


Simple Genetic Manipulation Could Extend Life 20%

By reducing the activity of one type of gene (mTOR), scientists said they increased the average life span of mice by about 20%, and preserved memory, cognition and other traits into old age. Though mouse studies don’t always translate to humans, Dr. Finkel, head of the laboratory of molecular biology in NIH‘s National Heart, Lung and Blood Institute and senior author of the new study said the results raise the possibility that targeting the gene with drugs that inhibit its activity might one day be at least part of a strategy for prolonging longevity in people. But researchers don’t know if whether inhibiting the action of the gene would have similar life-extending effects in humans, and if it did whether the benefit would come without unwanted problems.

singularity Drugs to slow aging through alterations to metabolism are not the path to radical life extension. Slowing aging does nothing for people already old. The research community should focus instead on rejuvenation through therapies that repair and remove the cellular damage that causes aging. The mice were bred to put out just 25 percent of the normal levels of mTOR protein, indicating that suppressing the activity of the gene “clearly makes mice live longer,” said Toren Finkel.

Microscopic Machines

Mass production of nanoscale components for the next generation of computers is now possible.  Researchers in Ireland have developed a new technology using materials called bulk metallic glasses to produce high-precision molds for making tiny plastic components. The components, with detailed microscopically patterned surfaces could be used in the next generation of computer memory devices and microscale testing kits and chemical reactors.

"Our technology is a new process for mass producing high-value polymer components, on the micrometer and nanometer-scale," explains Gilchrist. "This is a process by which high-volume quantities of plastic components can be mass produced with one hundred times more precision, for costs that are at least ten times cheaper than currently possible."

In their article published in the latest edition of Materials Today, Michael Gilchrist, David Browne and colleagues at University College Dublin explain how bulk metallic glasses (BMGs) were discovered about thirty years ago. These materials are a type of metal alloy, but instead of having a regular, crystalline structure like an everyday metal such as iron or an alloy like bronze, the material's atoms are arranged haphazardly. This disordered, or amorphous atomic structure is similar to the amorphous structure of the silicon and oxygen atoms in the glass we use for windows and drinking vessels.