Universal Vaccine Against Influenza A Viruses

Researchers have developed a universal vaccine to combat influenza A viruses that produces long-lasting immunity in mice and protects them against the limitations of seasonal flu vaccines, according to a study led by Georgia State UniversityInfluenza, a contagious respiratory illness that infects the nose, throat and lungs, is among the leading causes of death in the United States, according to the Centers for Disease Control and Prevention (CDC). The CDC estimates influenza has resulted in between 12,000 and 56,000 deaths annually in the U.S. since 2010. Seasonal flu vaccines must be updated each year to match the influenza viruses that are predicted to be most common during the upcoming flu season, but protection doesn’t always meet expectations or new viruses emerge and manufacturers incorrectly guess which viruses will end up spreading. In 2009, the H1N1 pandemic caused 200,000 deaths during the first 12 months, and low vaccine effectiveness was also observed during the 2014-15 and 2016-17 flu seasons. A universal flu vaccine that offers broad protection against various viruses is urgently needed and would eliminate the limitations of seasonal flu vaccines.

Seasonal flu vaccines provide protective immunity against influenza viruses by targeting the exterior head of the virus’s surface protein, which is hem
agglutinin
(HA). The influenza virus trains the body to produce antibodies against inactivated virus particles containing the head of this protein, ideally preventing the head from attaching to receptors and stopping infection. However, the head is highly variable and is different for each virus, creating a need for better vaccines. This study uses a new approach and instead targets the inside portion of the HA protein known as the stalk, which is more conservative and offers the opportunity for universal protection.

In this study, the researchers found vaccinating mice with double-layered protein nanoparticles that target the stalk of this protein produces long-lasting immunity and fully protects them against various influenza A viruses. The findings are published in the journal Nature Communications.

Source: http://news.gsu.edu/

How To Obtain Drinkable Water From Sea Water

Membranes made from graphene oxide could act as perfect molecular sieves when immersed in water, blocking all molecules or ions with a hydrated size larger than 9 Å. This new result, from researchers at the University of Manchester in the UK, means that the laminated nanostructures might be ideal for water filtration and desalination applications.
Graphene is a sheet of carbon just one atom thick in which the atoms are arranged in a honeycomb lattice. Graphene oxide is like ordinary graphene but is covered with molecules such as hydroxyl groups. Graphene-oxide sheets can easily be stacked on top of each other to form extremely thin but mechanically strong membranes. These membranes consist of millions of small flakes of graphene oxide with nanosized empty channels (or capillaries) between the flakes.


Water and small-sized ions and molecules permeate super fast in the graphene-oxide membrane, but larger species are blocked. The size of the membrane mesh can be tuned by adjusting the nanochannel size
According to the team, the membranes could be ideal for removing valuable salts and molecules from contaminated larger molecules – for example during oil spills. “More importantly, our work shows that if we were able to further control the capillary size below 9 Å, we should be able to use these membranes to filter and desalinate water,” says co-team-leader Rahul Nair.
Indeed, the team says that it is now busy looking at ways to control the mesh size of the graphene oxide and reduce it to about 6 Å so that the membranes can filter out even the smallest salts in sea water. “We might achieve this by preventing the graphene-oxide laminates from swelling when they are placed in water,” says Nair.
Our ultimate goal would be to make a filter device from the carbon-based material that allows you to obtain a glass of drinkable water from sea water using a hand-held mechanical pump,” adds team member Irina Grigorieva.
Source: http://physicsworld.com/