How To Generate Any Cell Within The Patient’s Own Body

Researchers at The Ohio State University Wexner Medical Center and Ohio State’s College of Engineering have developed a new technology, Tissue Nanotransfection (TNT), that can generate any cell type of interest for treatment within the patient’s own body. This technology may be used to repair injured tissue or restore function of aging tissue, including organs, blood vessels and nerve cells.

By using our novel nanochip technology (nanocomputer), injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining,” said Dr. Chandan Sen, director of Ohio State’s Center for Regenerative Medicine & Cell Based Therapies, who co-led the study with L. James Lee, professor of chemical and biomolecular engineering with Ohio State’s College of Engineering in collaboration with Ohio State’s Nanoscale Science and Engineering Center.

Researchers studied mice and pigs in these experiments. In the study, researchers were able to reprogram skin cells to become vascular cells in badly injured legs that lacked blood flow. Within one week, active blood vessels appeared in the injured leg, and by the second week, the leg was saved. In lab tests, this technology was also shown to reprogram skin cells in the live body into nerve cells that were injected into brain-injured mice to help them recover from stroke.

This is difficult to imagine, but it is achievable, successfully working about 98 percent of the time. With this technology, we can convert skin cells into elements of any organ with just one touch. This process only takes less than a second and is non-invasive, and then you’re off. The chip does not stay with you, and the reprogramming of the cell starts. Our technology keeps the cells in the body under immune surveillance, so immune suppression is not necessary,” said Sen, who also is executive director of Ohio State’s Comprehensive Wound Center.

Results of the regenerative medicine study have been published in the journal  Nature Nanotechnology.


How To Convert Heat Into Electricity

The same researchers who pioneered the use of a quantum mechanical effect to convert heat into electricity have figured out how to make their technique work in a form more suitable to industry. In Nature Communications, engineers from The Ohio State University (OSU) describe how they used magnetism on a composite of nickel and platinum to amplify the voltage output 10 times or more—not in a thin film, as they had done previously, but in a thicker piece of material that more closely resembles components for future electronic devices.

Many electrical and mechanical devices, such as car engines, produce heat as a byproduct of their normal operation. It’s called “waste heat,” and its existence is required by the fundamental laws of thermodynamics, explained study co-author Stephen Boona.

devices-that-convert-heat-into-electricityOver half of the energy we use is wasted and enters the atmosphere as heat,” said Boona, a postdoctoral researcher at Ohio State. “Solid-state thermoelectrics can help us recover some of that energy. These devices have no moving parts, don’t wear out, are robust and require no maintenance. Unfortunately, to date, they are also too expensive and not quite efficient enough to warrant widespread use. We’re working to change that.”But a growing area of research called solid-state thermoelectrics aims to capture that waste heat inside specially designed materials to generate power and increase overall energy efficiency.


Nanodrugs Help to cure 50 Rare Genetic Disorders

Researchers at Oregon State University and other institutions have discovered a type of drug delivery system that may offer new hope for patients with a rare, ultimately fatal genetic disorder – and make what might become a terrible choice a little easier.No treatment currently exists for this disease, known as Niemann Pick Type C1 disease, or NPC1, that affects about one in every 120,000 children globally, and results in abnormal cholesterol accumulation, progressive neurodegeneration and eventual death. However, a compound that shows promise is now undergoing clinical trials, but it has major drawbacks – the high doses necessary also cause significant hearing loss and lung damage, as well as requiring direct brain injection.

New findings, published today in Scientific Reports (“PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder”), outline the potential for a nanotechnology-based delivery system to carry the new drug into cells far more effectively, improve its efficacy by about five times, and allow use of much lower doses that may still help treat this condition without causing such severe hearing loss.The same system, they say, may ultimately show similar benefits for 50 or more other genetic disorders, especially those that require “brain targeting” of treatments.


Right now there’s nothing that can be done for patients with this disease, and the median survival time is 20 years,” said Gaurav Sahay, an assistant professor in the Oregon State University/Oregon Health & Science University College of Pharmacy, and corresponding author on the new study. “The new cholesterol-scavenging drug proposed to treat this disorder, called cyclodextrin , may for the first time offer a real treatment. But it can cause significant hearing loss and requires multiple injections directly into the brain, which can be very traumatic. I’m very excited about the potential of our new drug delivery system to address these problems.”


Brain Implant Moves Paralyzed Arm

This is Ian Burkhart of Ohio. His hands and legs were permanently paralyzed in a diving accident when he was 19 years old. But now with the help of a new, breakthrough computer chip implanted in his brain – the, now, 24-year-old is playing guitar hero.

brain implant helps paralized limbsCLICK ON THE IMAGE TO ENJOY THE VIDEO
When we first hooked everything up, you know for the first time being able to move my hand, it was a big shock because you know it was something that I have not moved in three and half years at that point, now it’s more of something where I expect it to move“,  says  Ian Burkhat, the quadriplegic patient at Ohio State University Wexner Medical Center.  The small pea-sized computer chip relays signals from Burkhart’s brain through 130 electrodes to his forearm, allowing his mind guide his hands and fingers, bypassing his damaged spinal cord. On Wednesday, scientists and neurosurgeons describing this quadriplegic’s accomplishments as a milestone in the evolution of brain-computer interface technology.

This really provides hope, we believe, for many patients in the future as this technology evolves and matures“, comments Doctor Ali Rezai, from the Ohio State’s Center for NeuroModulation. Burkhart says the progress is moving along faster than he imagined: “The biggest dream would be to get full function of my hand back, both my hands, because that would allow you to be much more independent, not to have to rely on people for simple day to day tasks that you take for granted.”

Scientists are working to improve the technology, which for now can only be used in the laboratory, and move toward a wireless system bringing Burkhart another step closer to his dream.


How To Clean Oil Spills For $1Per Square Foot

The unassuming piece of stainless steel mesh in a lab at The Ohio State University doesn’t look like a very big deal, but it could make a big difference for future environmental cleanups. Water passes through the mesh but oil doesn’t, thanks to a nearly invisible oil-repelling coating on its surface. In tests, researchers mixed water with oil and poured the mixture onto the mesh. The water filtered through the mesh to land in a beaker below. The oil collected on top of the mesh, and rolled off easily into a separate beaker when the mesh was tilted.
The mesh coating is among a suite of nature-inspired nanotechnologies under development at Ohio State and described in two papers in the journal Nature Scientific Reports. Potential applications range from cleaning oil spills to tracking oil deposits underground.

mesh captures oil
If you scale this up, you could potentially catch an oil spill with a net,” said Bharat Bhushan, Ohio Eminent Scholar and Howard D. Winbigler Professor of mechanical engineering at Ohio State.

The work was partly inspired by lotus leaves, whose bumpy surfaces naturally repel water but not oil. To create a coating that did the opposite, Bhushan and postdoctoral researcher Philip Brown chose to cover a bumpy surface with a polymer embedded with molecules of surfactant — the stuff that gives cleaning power to soap and detergent. They sprayed a fine dusting of silica nanoparticles onto the stainless steel mesh to create a randomly bumpy surface and layered the polymer and surfactant on top.
The silica, surfactant, polymer, and stainless steel are all non-toxic and relatively inexpensive, said Brown. He estimated that a larger mesh net could be created for less than a dollar per square foot.


Under Attack Robots Dance To Stay On Feet

It’s another day of abuse for this poor robot named Atrias. If not being kicked around, Atrias spends hours being pummelled by balls. But, remarkably, through the abuse, the robot stays on its feet. Unlike most bipedal robots which are designed to move like humans, researchers at Oregon State University modelled Atrias after a bird, creating what’s basically a robotic ostrich that conserves energy while maximizing agility and balance.
Atrias is fitted with two constantly moving pogo stick-like legs made of carbon fiber. Fiberglass springs store the mechanical energy produced while the robot makes unsuccessful attempts to avoid the punishment it receives from its creators. The researchers say that with a few more tweaks, the robots bird-like design will allow it to become the fastest two-legged robot ever built.
Atrias is funded by the U.S. Defense Department’s research arm, DARPA, who hope the robot will one day be able to work in hazard zones too dangerous for humans. But until that day comes – Atrias will just have to keep on taking the abuse — all in the name of science.

Cancer: If It Glows, Cut It Out Or Kill It !

Researchers at Oregon State University (OSU) have developed a new way to selectively insert compounds into cancer cells – a system that will help surgeons identify malignant tissues and then, in combination with phototherapy, kill any remaining cancer cells after a tumor is removed. It’s about as simple as, “If it glows, cut it out.” And if a few malignant cells remain, they’ll soon die.
Technology such as this, scientists said, may have a promising future in the identification and surgical removal of malignant tumors, as well as using near-infrared light therapies that can kill remaining cancer cells, both by mild heating of them and generating reactive oxygen species that can also kill them.
Scientists have developed a a new method that sees cancer cells glow, potentially allowing for more accurate surgeries
This is kind of a double attack that could significantly improve the success of cancer surgeries,” said Oleh Taratula, an assistant professor in the OSU College of Pharmacy.
With this approach, cancerous cells and tumors will literally glow and fluoresce when exposed to near-infrared light, giving the surgeon a precise guide about what to remove,” Taratula said. “That same light will activate compounds in the cancer cells that will kill any malignant cells that remain. It’s an exciting new approach to help surgery succeed.”

The findings, published in the journal Nanoscale, have shown remarkable success in laboratory animals. The concept should allow more accurate surgical removal of solid tumors at the same time it eradicates any remaining cancer cells. In laboratory tests, it completely prevented cancer recurrence after phototherapy.


Graphene soaks up Carbon, Cause of Global Warming

Chemists and engineers at Oregon State University (OSU) have discovered a fascinating new way to take some of the atmospheric carbon dioxide that’s causing the greenhouse effect and use it to make an advanced, high-value material for use in energy storage products.This innovation in nanotechnology won’t soak up enough carbon to solve global warming, researchers say. However, it will provide an environmentally friendly, low-cost way to make nanoporous graphene for use in “supercapacitors” – devices that can store energy and release it rapidly. Such devices are used in everything from heavy industry to consumer electronics.

greenhouse gas2
There are other ways to fabricate nanoporous graphene, but this approach is faster, has little environmental impact and costs less,” said Xiulei (David) Ji, an OSU assistant professor of chemistry in the OSU College of Science and lead author on the study. “The product exhibits high surface area, great conductivity and, most importantly, it has a fairly high density that is comparable to the commercial activated carbons. “And the carbon source is carbon dioxide, which is a sustainable resource, to say the least,” Ji said. “This methodology uses abundant carbon dioxide while making energy storage products of significant value.”

The findings were just published in Nano Energy by scientists from the OSU College of Science, OSU College of Engineering, Argonne National Laboratory, the University of South Florida and the National Energy Technology Laboratory in Albany, Ore. The work was supported by OSU.


How To Become The “Henry Ford” Of Nanotechnology

We want to make things better, faster, cheaper – like everyone else,” said Jessica Winter, associate professor of chemical engineering at Ohio State UniversityOSU -. “One major difference between what we do and standard manufacturing is we can’t see it.”
Winter and a group of four co-investigators in September won a four-year grant worth $1.2 million from the National Science Foundation to perfect a process that would allow for continuous mass production of nanoparticles – polymer bundles so small that five could stretch across a single strand of DNA.ohio-state-nanotechnology

Ohio State University chemical and biomolecular engineering department researchers, left to right, Jessica Winter, Lisa Hall and Barbara Wyslouzil won a federal grant to perfect a continuous production process for nanoparticles


Salt, Key Element To Mass Production Of Nanostructures

Chemists at Oregon State University have identified that salt could significantly reduce the cost and potentially enable the mass commercial production of silicon nanostructures – materials that have huge potential in everything from electronics to biomedicine and energy storage. Simple sodium chloride, most frequently found in a salt shaker, has the ability to solve a key problem in the production of silicon nanostructures, researchers just announced in Scientific Reports, a professional journal. By melting and absorbing heat at a critical moment during a “magnesiothermic reaction,” the salt prevents the collapse of the valuable nanostructures that researchers are trying to create. The molten salt can then be washed away by dissolving it in water, and it can be recycled and used again.

silicon nanostructure 2

This could be what it takes to open up an important new industry,” said David Xiulei Ji, an assistant professor of chemistry in the OSU College of Science. “There are methods now to create silicon nanostructures, but they are very costly and can only produce tiny amounts“. “The use of salt as a heat scavenger in this process should allow the production of high-quality silicon nanostructures in large quantities at low cost,” he said. “If we can get the cost low enough many new applications may emerge.”

Low-Cost Solar Energy

A process combining some comparatively cheap materials and the same antifreeze that keeps an automobile radiator from freezing in cold weather may be the key to making solar cells that cost less and avoid toxic compounds, while further expanding the use of solar energy. And when perfected, this approach might also cook up the solar cells in a microwave oven similar to the one in most kitchens.
Engineers at Oregon State University (OSU) have determined that ethylene glycol, commonly used in antifreeze products, can be a low-cost solvent that functions well in a “continuous flow” reactor – an approach to making thin-film solar cells that is easily scaled up for mass production at industrial levels.
solar nanoparticles

The global use of solar energy may be held back if the materials we use to produce solar cells are too expensive or require the use of toxic chemicals in production,” said Greg Herman, an associate professor in the OSU School of Chemical, Biological and Environmental Engineering. “We need technologies that use abundant, inexpensive materials, preferably ones that can be mined in the U.S. This process offers that.”