Tag Archives: immune system

The Immune System’s Fountain of Youth

If only we could keep our bodies young, healthy and energetic, even as we attain the wisdom of our years. New research at the Weizmann Institute of Science in Israel suggests this dream could be at least partly obtainable in the future. The results of this research, led by Prof. Valery Krizhanovsky and Dr. Yossi Ovadya in the Molecular Cell Biology Department, were recently published in Nature Communications.

The research began with an investigation into the way that the immune system is involved in a crucial activity: clearing away old, senescent cells that spell trouble for the body when they hang around. Senescent cells – not completely dead but suffering loss of function or irreparable damage – have been implicated in diseases of aging by promoting inflammation. The researchers used mice in which a crucial gene for this immune activity was missing. At two years (elderly, for mice), the bodies of these mice had a greater accumulation of senescent cells compared with the mice in which the gene for removing these cells was intact. The mice missing the gene suffered from chronic inflammation, and various functions in their bodies appeared to be diminished. They also looked older – and died earlier – than their normal counterparts.

Drug treatment eliminates senescent cells from tissues of old mice. The blue staining shows senescent cells in lung and liver tissue. The amount of the staining is significantly reduced following the drug treatment

Next, the researchers gave the mice a drug that inhibits the function of certain proteins that help the aging cells survive in their senescent state, to see if this would contribute to the removal of these cells from the body. The drugs were administered to mice whose aging was a result of the malfunctions the group had uncovered in the immune system as well as those suffering premature aging from a different genetic error. The treated mice responded exceptionally well to the drug: Their blood tests and activity tests showed improvement, and their tissues appeared to be much closer to those of young mice. The scientists counted senescent cells, finding many fewer of them remaining in the treated mice’s bodies; and when they looked for signs of inflammation, they found that this, too, was significantly lower. The mice treated with the drug were more active and their median lifespan rose.

Source: https://wis-wander.weizmann.ac.il/

Man With Multiple Sclerosis Walks Again After Stem Cell Transplant

For a decade, Roy Palmer had no control of his legs. The man from Gloucester, England, had multiple sclerosis, or MS, which results in the body’s immune system eating away at the protective covering of nerves, disrupting communication between the brain and the body.  Palmer had no feeling in his legs and used a wheelchair. But last year, he received a life-changing treatment that restored his ability to walk — and dance — again,the BBC reports. The dad first heard of the treatment, called HSCT (hematopoietic stem cell transplantation), on the BBC program, “Panorama.”

Two people on that program went into Sheffield Hospital in wheelchairs and they both came out walking,” Palmer said. “As soon as we saw that, we both cried,” Palmer’s wife told the BBC. According to the National MS Society, HSCT still considered experimental, but Palmer decided it was worth a try.

CLICK ON THE IMAGE TO ENJOY THE VIDEO

If they can have that done, on a trial, why can’t I have it done?” Palmer said. So last year, the 49-year-old started the grueling treatment, which is potentially risky, the BBC reports. HSCT doesn’t always work and there is a long-term risk of infection and infertility. “They take the stem cells out of your body. They give you chemotherapy to kill the rest of your immune system,” Palmer told the BBC. The stem cells are then used to reboot the immune system. “Let’s hope it works,” Palmer adds in a home video taken just before the treatment. It did. After HSCT, he regained feeling in his left leg within two days. “I haven’t felt that in 10 years,” comments Palmer. “It’s a miracle.” Eventually, he regained feeling in both of his legs and began to walk.

Source: https://www.cbsnews.com/