Tag Archives: infections

How To Fight Against Weakened Immune System When Getting Older

Scientists pinpoint metabolic pathway behind age-related immunity lossThe elderly suffer more serious complications from infections and benefit less from vaccination than the general population. Researchers have long known that a weakened immune system is to blame but the exact mechanisms behind this lagging immunity have remained largely unknownNow research led by investigators at Harvard Medical School suggests that weakened metabolism of immune T cells may be partly to blame.

The findings, published Dec. 10 in PNAS and based on experiments in mouse immune cells, pinpoint a specific metabolic pathway called one-carbon metabolism that is deficient in the aged T cells of rodents. The work also suggests possible ways to restore weakened immune function with the use of small-molecule compounds that boost T cell performance.

We believe our findings may help explain the basic malfunction that drives loss of immune defenses with age,” said senior study author Marcia Haigis, professor of cell biology in the Blavatnik Institute at Harvard Medical School. “If affirmed in further studies, we hope that our findings can set the stage for the development of therapies to improve immune function.

Source: https://scienmag.com/

One Dollar Hand Kit Detects and Diagnoses Diseases

A test kit that can fit into the palm of a hand could be changing the face of disease screening and diagnosis. Developed by a multidisciplinary team of the National University of Singapore (NUS) researchers, the device named enVision (enzyme-assisted nanocomplexes for visual identification of nucleic acids) is a versatile platform that can conduct specific and sensitive screening and detection for a range of diseases, from infectious diseases and high-prevalence infections, to various types of cancers and genetic diseases.

More effective and less costly than existing infection diagnostic methods, enVision, which took about one-and-a-half years to develop, takes between 30 minutes to one hour to detect diseases — two to four times faster — and each test kit costs under $1 — about 100 times cheaper.

The enVision platform is extremely sensitive, accurate, fast, and low-cost. It works at room temperature and does not require heaters or special pumps, making it very portable. With this invention, tests can be done at the point-of-care, for instance in community clinics or hospital wards, so that disease monitoring or treatment can be administered in a timely manner to achieve better health outcomes,” said team leader Assistant Professor Shao Huilin from the Biomedical Institute for Global Health Research and Technology (BIGHEART) at NUS and NUS Biomedical Engineering.

Source: https://news.nus.edu.sg/